Clinical Translational Research Center for Neurodevelopmental Disorders

神经发育障碍临床转化研究中心

基本信息

批准号：
9296167
负责人：
Joseph Piven
金额：
$ 130万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-24 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9296167
关键词：
Address Animal Experimentation Autistic Disorder Basic Science Behavioral Bioinformatics Biostatistics Core Brain Brain imaging Caliber Center for Translational Science Activities Child Clinical Clinical Research Clinical Sciences Clinical Services Collaborations Complex Development Developmental Disabilities Discipline Early Diagnosis Early Intervention Elements Environment Fostering Functional Magnetic Resonance Imaging Funding Goals Human Image Analysis Individual Institutes Intellectual functioning disability Interdisciplinary Study Intervention Laboratories Measurement Mediating Mental Retardation and Developmental Disabilities Research Centers Mentorship Microscopy Motivation Mus National Institute of Child Health and Human Development Nature Neurodevelopmental Disorder Neurons North Carolina Oxytocin Participant Pathogenesis Pathway interactions Phenotype Pre-Clinical Model Prevention Prevention strategy Registries Regulation Research Research Personnel Research Project Grants Research Support Research Training Resources Rewards Sampling Science Social Behavior Social Controls Syndrome Training Training and Education Translational Research U-Series Cooperative Agreements United States National Institutes of Health Universities autism spectrum disorder base brain behavior collaborative environment cost effective disability improved innovation interest mesolimbic system motivated behavior mouse model multidisciplinary neural circuit new therapeutic target optogenetics pre-clinical pre-doctoral programs response reward circuitry social synergism training opportunity

项目摘要

DESCRIPTION (provided by applicant): The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmenta disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 39 investigators from 16 University departments, and includes 67 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Autism and Related Neurodevelopmental Disorders; (2) Brain and Behavior Development; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores - a Clinical Translational Core, which includes the Research Participant Registry and Brain Measurement Laboratory; a Preclinical Core, which includes the Mouse Behavioral Phenotyping, Brain Imaging Analysis, and Confocal/Multiphoton Microscopy Labs; and the Bioinformatics/Biostatistics Core; and (3) a preclinical/clinical research project entitled "Neural Circuit Regulation of Social Reward Motivation" potentially providing important new information related to novel therapeutic targets for normalizing social behavior in individuals with ASD. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinar, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.

描述（由申请人提供）：北卡罗来纳大学的知识与发展障碍研究中心（IDDRC）是一项跨学科计划，其总体目标是支持和促进与了解神经发育障碍的发病机理和治疗有关的研究。 UNC IDDRC是新卡罗来纳州发育障碍研究所（CIDD）的关键组成部分，这是与知识分裂和发展障碍（IDDS）相关的临床服务，研究和培训的焦点。 UNC IDDRC目前支持来自16个大学系的39名调查人员，其中包括67个外部资助的研究项目。该IDDRC的基于广泛的研究计划围绕了3个主题：（1）自闭症和相关的神经发育障碍；（2）大脑和行为发展；（3）早期检测/干预。 UNC IDDRC是一项高度协作的计划，该计划由数个资助，跨学科研究中心/计划的存在强调。本应用程序寻求支持：（1）行政核心；（2）三个研究核心 - 一个临床翻译核心，其中包括研究参与者注册表和大脑测量实验室；临床前核，其中包括小鼠行为表型，脑成像分析和共聚焦/多光子显微镜实验室；以及生物信息学/生物统计学核心；（3）一个临床前/临床研究项目，题为“社会奖励动机的神经回路调节”可能提供了与新型治疗靶标有关的重要新信息，以使ASD患者的社会行为正常化。提出的三个研究核心为这一综合，多学科，IDD与IDD与IDD相关的研究提供了尖端，高质量和具有成本效益的支持。总体而言，该中心对北卡罗来纳大学大学发展障碍研究和科学培训产生了重大影响，更新将使我们能够继续支持UNC在UNC进行的IDD研究的真正杰出计划。