The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS

东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟

基本信息

批准号：
10084048
负责人：
DARRON R BROWN
金额：
$ 99.53万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-07 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10084048
关键词：
AIDS related cancer AIDS/HIV problem Acetic Acids Aflatoxins Africa Africa South of the Sahara African Biological Biological Factors Biological Markers Biometry Cervical Cervical Cancer Screening Cervical Intraepithelial Neoplasia Cervical dysplasia Cervix Neoplasms Clinical Communicable Diseases Data Development Diagnosis Environmental Risk Factor Epidemiology Goals HIV HPV-High Risk Human Papillomavirus Human papilloma virus infection Incidence Ingestion Institutes Kenya Knowledge Lesion Local Therapy Malignant Neoplasms Malignant neoplasm of cervix uteri Mentors Natural History Nurses Outcome Physicians Pilot Projects Prevalence Research Research Infrastructure Research Personnel Resource Sharing Scientist Testing Training Training Programs Translational Research Triage Uganda Viral Visual Woman antiretroviral therapy carcinogenesis career cervical carcinogenesis cofactor data management design international partnership loop electrosurgical excision procedure low and middle-income countries premalignant prevent programs screening viral DNA

项目摘要

Overall Abstract Sub-Saharan Africa contains 70% of the world’s diagnosed cases of HIV/AIDS, with both Uganda and Kenya at its epicenter (12% and 7% prevalence, respectively). Within East Africa, cervical cancer remains one of the most common malignancies in women. HIV is a contributing factor for cervical carcinogenesis with HIV-infected women having a greater incidence and persistence of human papilloma virus (HPV) infections, cervical cancer, and precancerous cervical lesions. In contrast to other HIV-associated cancers, the incidence of cervical cancer has not declined in the era of antiretroviral therapy. The core objective of this application is to better elucidate the natural history of HPV infection and cervical cancer in HIV-infected women, including the cofactors involved in carcinogenesis, the persistence and progression of cervical intraepithelial neoplasia (CIN) after LEEP, and to identify new viral and cellular biomarkers that will assist in screening, triage and treatment. Our central hypothesis is that the incidence, persistence, and spectrum of high risk (HR) HPV are substantially greater in HIV-infected East African women, and that this explains the higher incidence of cervical neoplasia. We further hypothesize that these and other modifiable factors, such as aflatoxin ingestion, disproportionately and adversely influence outcomes of local therapies such as Loop Electrosurgical Excision Procedure (LEEP) in HIV-infected women. The specific aims for the East Africa Consortium for HPV and Cervical Cancer (EACHC) in Women Living with HIV/AIDS are: Specific Aim 1. To establish a sustainable research infrastructure for an international partnership to conduct impactful research in HPV and cervical cancer in women living with HIV/AIDS Specific Aim 2. To design and execute three integrated projects that advance the knowledge of the environmental and biologic factors leading to cervical cancer in East Africa: Project 1- Preventing cervical cancer in HIV-infected women Project 2- Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study Project 3- Determining biological and viral factors associated with clinical progression of cervical dysplasia in HIV-infected women Specific Aim 3. To increase the research workforce capacity in East Africa through mentoring, training programs and targeted pilot projects

总体抽象撒哈拉以南非洲含有世界诊断出的艾滋病毒/艾滋病案件的70％，乌干达和肯尼亚都在它的震中（分别为12％和7％的患病率）。在东非，宫颈癌仍然是最多的女性常见的恶性肿瘤。 HIV是宫颈致癌的因素，并受到HIV感染人类乳头瘤病毒（HPV）感染，宫颈癌的发生率和持久性的妇女，宫颈癌，和癌前颈病变。与其他与HIV相关的癌症相反，宫颈癌的事件在抗逆转录病毒疗法时代，尚未下降。该应用的核心目的是更好地阐明HPV感染和宫颈癌的自然历史在艾滋病毒感染的妇女中，包括涉及癌变的辅助因子，持久性和进展 LEEP之后的宫颈上皮内肿瘤（CIN），并确定将有助于的新病毒和细胞生物标志物在筛查，分类和治疗中。我们的核心假设是，HPV的事件，持久性和高风险（HR）的频谱基本上是在艾滋病毒感染的东非妇女中更大，这解释了宫颈肿瘤的较高事件。我们进一步假设这些和其他可修改因素（例如黄曲霉毒素摄入）不成比例并不利地影响局部疗法的结果，例如循环电外科切除程序（LEEP）在艾滋病毒感染的妇女中。 East Africa Consortium HPV和宫颈癌（Averc）的具体目的是艾滋病毒/艾滋病是：具体目标1。建立可持续的研究基础设施以进行国际伙伴关系以进行 HPV和宫颈癌的有影响力的研究对艾滋病毒/艾滋病的女性具体目标2。设计和执行三个集成项目，以提高知识的知识导致东非宫颈癌的环境和生物学因素：项目1-预防艾滋病毒感染妇女的宫颈癌项目2-了解艾滋病毒感染妇女的CIN2+在LEEP之后：流行病学和免疫组织化学研究项目3-确定与宫颈发育不良的临床进展相关的生物学和病毒因子在艾滋病毒感染的妇女中特定目标3。通过心理，培训计划提高东非的研究劳动力能力和针对性的飞行员项目