EnerCage: A Scalable Array of Intelligent Wireless Sensor Modules to Energize and

EnerCage：可扩展的智能无线传感器模块阵列，用于提供能量和

• 批准号: 7786827
• 负责人: Maysam Ghovanloo
• 金额: $ 18.11万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786827
• 关键词: 3-Dimensional; Address; Amplifiers; Animals; Area; Behavioral; Brain; Data; Development; Devices; Diagnosis; Disease; Dorsal; Electronics; Electrophysiology (science); Encapsulated; Epilepsy; Evaluation; Functional disorder; Goals; Habitats; Hand; Head; Hippocampus (Brain); Hour; Housing; Human; Interruption; Intervention; Knowledge; Laboratory Animals; Life; Location; Longevity; Magnetism; Measures; Memory; Monitor; Morphologic artifacts; Motion; Nervous system structure; Neurofibrillary Tangles; Neurons; Neurosciences; Noise; Performance; Pharmaceutical Preparations; Positioning Attribute; Power Sources; Predisposition; Prevention; Primates; Principal Investigator; Printing; Rattus; Research; Research Personnel; Rodent; Schizophrenia; Shapes; Short-Term Memory; Signal Transduction; Solutions; System; Technology; Testing; Time; Tongue; Tracer; Translational Research; Vision; Visual system structure; Weight; Wireless Technology; Yin; area striata; base; computer network; cost; data acquisition; depression; design; experience; in vivo; instrumentation; new technology; novel; programs; public health relevance; receptive field; relating to nervous system; research study; restraint; sensor; success; tool

DESCRIPTION (provided by applicant): A major goal of neuroscience is to study the functional organization of the nervous system in animals to generate the knowledge that will eventually aid in prevention, diagnosis, and treatment of disease and dysfunction in the human brain. In vivo electrophysiology (in live animal subjects) has been a powerful tool in pursuing that goal. It has provided groundbreaking information on areas ranging from the organization of primary visual cortex to neural correlates of working memory, which has helped in the treatment of disorders ranging from schizophrenia to epilepsy to depression. It has also helped in evaluation of various interventions in translational research on new medications and neuroprosthetic devices. Many experimental questions, particularly in behavioral neuroscience, require awaken freely moving subjects, and logistical constraints such as issues of cost, life-span, and housing often necessitate using small animals such as rodents. The technical challenges to this approach center on finding ways to record high quality neural signals for extended periods, while allowing small animals to move unencumbered by restraints or recording cables and unburdened by the weight and size of the battery-powered wireless recording instrumentation. The current proposal describes research which aim is to develop and test a new technology to overcome these challenges. In particular, we propose to develop a new inductively-powered wireless electrophysiological data acquisition system, called the EnerCage, which not only acquires and transmits neural signals wirelessly but also receives power wirelessly. Therefore it permits multichannel recordings for many hours in large and completely enclosed experimental arenas, similar to rodents' natural habitat. Most wireless data acquisition solutions use batteries to power the electronics carried by the animal, which necessitates a compromise between the duration of the experiments and the weight that the animal can carry. As a result, most researchers forgo the numerous benefits of wireless data acquisition systems and use systems that tether behaving animals to electrophysiology instrumentation through cables. The use of these cables results in substantial limitations on weight, the range over which an animal can traverse, susceptibility to noise, motion artifacts, and the need for expensive commutators to eliminate tangling and twisting. The EnerCage system, on the other hand, will offer key advantages including 1) a substantial reduction in the weight and size of the headstage that should be supported by the animal, 2) an unlimited operating time of the inductively powered transmitter, 3) an extendable area over which the animal can traverse, and 4) accurate monitoring of the 3-D position and orientation of a magnetic tracer affixed to the animal's headstage, which does not require the animal to be in the line of sight. PUBLIC HEALTH RELEVANCE: We propose to develop a new inductively-powered wireless electrophysiological data acquisition system, which not only acquires and transmits neural signals wirelessly but also receives power wirelessly. Therefore it permits multichannel recordings for many hours by eliminating the need for carrying batteries on the animal body in large and completely enclosed experimental arenas, similar to rodents' natural habitat.

描述（由申请人提供）：神经科学的一个主要目标是研究动物神经系统的功能组织，以产生最终有助于预防、诊断和治疗人脑疾病和功能障碍的知识。 体内电生理学（在活体动物受试者中）一直是实现这一目标的强大工具。 它提供了从初级视觉皮层的组织到工作记忆的神经相关性等领域的开创性信息，这有助于治疗从精神分裂症到癫痫再到抑郁症等疾病。 它还有助于评估新药物和神经修复装置转化研究中的各种干预措施。 许多实验问题，特别是行为神经科学中的实验问题，需要唤醒自由活动的受试者，而成本、寿命和住房问题等后勤限制往往需要使用啮齿类动物等小动物。 这种方法的技术挑战集中在寻找长时间记录高质量神经信号的方法，同时允许小动物不受约束或记录电缆的阻碍而移动，并且不受电池供电的无线记录仪器的重量和尺寸的负担。 当前的提案描述了旨在开发和测试新技术以克服这些挑战的研究。 特别是，我们建议开发一种新型感应供电无线电生理数据采集系统，称为 EnerCage，它不仅可以无线采集和传输神经信号，还可以无线接收电力。 因此，它允许在大型且完全封闭的实验场地（类似于啮齿动物的自然栖息地）进行多个小时的多通道录音。 大多数无线数据采集解决方案使用电池为动物携带的电子设备供电，这需要在实验持续时间和动物可携带的重量之间进行折衷。 因此，大多数研究人员放弃了无线数据采集系统的众多优势，转而使用通过电缆将行为动物与电生理仪器相连的系统。 这些电缆的使用导致重量、动物可以行走的范围、对噪音的敏感性、运动伪影的敏感性以及需要昂贵的换向器来消除缠结和扭曲的巨大限制。 另一方面，EnerCage 系统将提供主要优势，包括 1) 大幅减少动物支撑的探头的重量和尺寸，2) 感应供电发射器的无限运行时间，3)动物可以穿越的可扩展区域，以及 4) 精确监控固定在动物头部的磁示踪剂的 3D 位置和方向，这不需要动物位于视线范围内。 公共健康相关性：我们建议开发一种新型感应供电无线电生理数据采集系统，该系统不仅可以无线采集和传输神经信号，还可以无线接收电力。 因此，在大型且完全封闭的实验场地（类似于啮齿动物的自然栖息地）中，无需在动物身上携带电池，从而可以进行多个小时的多通道记录。