Translational Biology Core

转化生物学核心

• 批准号: 8935196
• 负责人: DARRON R BROWN
• 金额: $ 9.55万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8935196
• 关键词: Acquired Immunodeficiency Syndrome; Africa South of the Sahara; American; Biology; Biopsy; Biostatistics Core; Cancerous; Cervical; Cervical Intraepithelial Neoplasia; Cervical dysplasia; Chlamydia trachomatis; Cold Therapy; Data; Development; Diagnosis; Educational process of instructing; Epidemiology; Future; Genotype; HIV; Head and Neck Cancer; Health Services Accessibility; Human Papillomavirus; Human papilloma virus infection; Incidence; Indiana; Infection; Institutes; Kenya; Knowledge; Laboratories; Life; Loop electrosurgical excision procedure; Malignant Neoplasms; Malignant Vaginal Neoplasm; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of vulva; Medical Research; Mentors; Modeling; Molecular Epidemiology; Neisseria gonorrhoeae; Oncogenic; Physicians; Prevention; Principal Investigator; Process; Research Institute; Research Personnel; Risk; Role; Sampling; Scientist; Sexually Transmitted Diseases; Site; Students; Swab; Testing; Transportation; Universities; Vagina; Woman; biobank; burden of illness; data management; experience; graduate student; medical schools; oncology

Translational Biology Core The objective of the Translational Biology Core (TBC) is to provide support to Projects 1 ("Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV-positive Kenyan women") and Project 2 ("Results of Cryotherapy/LEEP among HIV- and HIV+ Women in Western Kenya") of the AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS. This support will include storage of samples, transportation of samples between testing sites, STI testing, HPV genotyping, and providing a space in which young physician scientists, graduate students, and technicians can expand their laboratory repertoire. The division of labor will occur between two sites: 1) Academic Model Providing Access to Healthcare (AMPATH) in partnership with the Moi University School of Medicine (MUSOM) in Eldoret, Kenya and 2) Kenya Medical Research Institute (KEMRI) in Kisumu, Kenya. Both laboratories have unique capabilities that will be integrated to provide the testing necessary to complete these projects outlined in this proposal. The other role of the TBC is to interact with the Mentoring Core (MC) and the Biostatistics Core and Data Management (BC). The TBC will be generating the data that will be further analyzed by the BC and will regularly collaborate with them. The TBC will also provide the space for teaching trainees that will be guided by the MC.

翻译生物学核心 转化生物学核心（TBC）的目的是为项目1提供支持（“可修改的因素预测HIV阳性肯尼亚妇女的致癌性HPV和宫颈发育不良的持续性”）和项目2（肯尼亚西部的HIV和HIV妇女中的冷冻疗法/LEEP妇女的Cryothapy/Leep妇女的疾病中的Cryothapy/Leep妇女的癌症”（HIV）妇女的疾病：艾滋病毒/艾滋病。这种支持将包括样品的存储，测试站点之间的样品运输，STI测试，HPV基因分型，以及提供一个年轻的医师科学家，研究生和技术人员可以扩大实验室曲目的空间。劳工部将在两个地点之间发生：1）与肯尼亚基苏木的肯尼亚医学研究所（KEMRI）合作，与MOI大学医学院（MUSOM）合作，提供获得医疗保健（AMPATH）的学术模型。这两个实验室都具有独特的功能，可以集成以提供完成本提案中概述的这些项目所必需的测试。 TBC的另一个作用是与指导核心（MC）以及生物统计学核心和数据管理（BC）互动。 TBC将生成将由卑诗省进一步分析的数据，并定期与他们合作。 TBC还将为教学人员提供由MC指导的教学人员的空间。