Neural and Cognitive Mechanisms of Attention and Memory Deficits in Cancer Survivors

癌症幸存者注意力和记忆缺陷的神经和认知机制

基本信息

批准号：
10117216
负责人：
James C Root
金额：
$ 8.85万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10117216
关键词：
Active Learning Address Adult Affect Age Animals Attention Attentional deficit Awareness Behavior Control Behavioral Brain Breast Cancer Patient Breast Cancer Treatment Breast Cancer survivor Cancer Intervention Cancer Survivor Chemotherapy and/or radiation Clinical Cognitive Cognitive remediation Development Electroencephalography Event-Related Potentials Failure Goals Intervention Judgment Knowledge Learning Life Malignant Neoplasms Measurement Measures Memory Memory impairment Methods Monitor Neuropsychological Tests Participant Pattern Performance Population Preventive treatment Process Psychologist Rehabilitation therapy Reporting Research Retrieval Stimulus Survivors Testing Time TimeLine Work base cancer therapy cancer-related cognitive impairment chemotherapy cognitive change cognitive function cognitive neuroscience cognitive process effective therapy experience experimental study forgetting information processing innovation long term memory malignant breast neoplasm memory process metacognition novel strategies prevent relating to nervous system remediation response sensory gating stem success sustained attention

Active Learning Address Adult Affect Age Animals Attention Attentional deficit Awareness Behavior Control Behavioral Brain Breast Cancer Patient Breast Cancer Treatment Breast Cancer survivor Cancer Intervention Cancer Survivor Chemotherapy and/or radiation Clinical Cognitive Cognitive remediation Development Electroencephalography Event-Related Potentials Failure Goals Intervention Judgment Knowledge Learning Life Malignant Neoplasms Measurement Measures Memory Memory impairment Methods Monitor Neuropsychological Tests Participant Pattern Performance Population Preventive treatment Process Psychologist Rehabilitation therapy Reporting Research Retrieval Stimulus Survivors Testing Time TimeLine Work base cancer therapy cancer-related cognitive impairment chemotherapy cognitive change cognitive function cognitive neuroscience cognitive process effective therapy experience experimental study forgetting information processing innovation long term memory malignant breast neoplasm memory process metacognition novel strategies prevent relating to nervous system remediation response sensory gating stem success sustained attention

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项目摘要

PROJECT ABSTRACT Despite evidence that cancer survivors frequently report difficulties with long-term memory, traditional neuropsychological test batteries often fail to detect significant memory deficits in this population. Instead, recent research has suggested that complaints of `forgetfulness' often associated with cancer-related cognitive dysfunction (CRCD) can actually be attributed to failures during initial learning that result from attentional difficulties, rather than memory decay. However, no studies to date have directly tested how attentional failures in CRCD impact downstream memory processes such as initial learning success and subsequent retrieval performance. Moreover, the finding that survivors often mischaracterize attention problems as memory problems during retrieval raises the question of whether survivors have accurate awareness of their own cognitive failures in real time (metamemory). Accurate awareness of errors is critical to the efficacy of current cognitive remediation methods that rely on survivors' ability to accurate detect errors as they occur. To address these gaps in knowledge, we have developed an experiment that draws on methods from cognitive neuroscience of memory and metacognition to examine effects of attention on initial learning and subsequent retrieval in CRCD, as well as assess survivors' awareness of their own cognitive processes throughout the task. We will use electroencephalography (EEG) to examine the cognitive and neural underpinnings of attention and memory processes in breast cancer patients treated with chemotherapy and radiation (N=24), as compared to age-matched healthy adults (N=24). Participants will undergo EEG recording while completing a long-term memory task, including on-line subjective assessments of their own learning and retrieval performance. The objective of this proposal is to use EEG in conjunction with a cognitive-experimental paradigm to evaluate the following specific aims: Aim 1: Examine whether cancer survivors demonstrate abnormal ERP components during initial learning, and whether these are correlated with subsequent retrieval failures; and Aim 2: Use a metamemory task to assess the accuracy of survivors' subjective confidence in their initial learning and retrieval ability. This research is significant because use of cognitive-experimental measures could more precisely identify effects of attentional failures on initial learning in CRCD and evaluate whether survivors are deficient in the ability to accurately detect these failures in real time, which will inform the development of effective treatment interventions. This research is innovative because it uses cognitive neuroscience-based methods to test both neural and cognitive mechanisms involved in attention, learning, and retrieval, and utilizes a metamemory paradigm to evaluate survivors' accuracy in detecting cognitive errors during learning. The use of these tasks allows for measurement of both objective and subjective cognitive processes along the learning and memory timeline which, to date, have not been evaluated in cancer survivors suffering from CRCD.

项目摘要尽管有证据表明癌症幸存者经常报告长期记忆的困难，但传统神经心理测试电池通常无法检测到该人群中的大量记忆缺陷。反而，最近的研究表明，“健忘”的抱怨通常与癌症相关的认知有关功能障碍（CRCD）实际上可以归因于初始学习期间的失败，这是由于注意力困难，而不是记忆衰减。但是，迄今为止尚无研究直接测试注意力 CRCD的失败影响下游记忆过程，例如初始学习成功和随后检索性能。此外，幸存者经常将注意力问题误解为检索期间的记忆问题提出了一个问题，即幸存者是否对自己的意识具有准确的认识实时自己的认知失败（metamemory）。准确对错误的意识对于有效性至关重要当前的认知补救方法依赖于幸存者在发生错误时准确检测错误的能力。到解决这些知识的差距，我们开发了一个实验，该实验利用了认知的方法记忆和元认知的神经科学，以检查注意力对初始学习的影响在CRCD中检索，并评估幸存者对自己的认知过程的认识任务。我们将使用脑电图（EEG）检查接受化学疗法和放射治疗的乳腺癌患者的注意力和记忆过程（n = 24），与年龄匹配的健康成年人相比（n = 24）。参与者将在完成A时进行脑电图记录长期记忆任务，包括对自己的学习和检索的在线主观评估表现。该提案的目的是将脑电图与认知实验性结合使用评估以下特定目的的范式：目标1：检查癌症幸存者是否证明初始学习期间的异常ERP组件，以及它们是否与随后的检索相关失败；目标2：使用元素任务来评估幸存者对其主观信心的准确性最初的学习和检索能力。这项研究很重要，因为使用认知实验措施可以更精确地识别注意力失败对CRCD初始学习的影响，并评估幸存者是否缺乏能够实时准确检测这些失败，这将为有效治疗的发展提供信息干预措施。这项研究具有创新性，因为它使用基于认知神经科学的方法来测试注意，学习和检索涉及的神经和认知机制，并利用元素范式评估幸存者在学习过程中检测认知错误的准确性。这些任务的使用允许沿学习和记忆的客观和主观认知过程测量迄今为止尚未评估患有CRCD的癌症幸存者的时间表。