Exploratory Center of Excellence for Advancing Multimorbidity Science (CAMS)

促进多种疾病科学卓越探索中心 (CAMS)

• 批准号: 10121495
• 负责人: SUE E GARDNER
• 金额: $ 37.47万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121495
• 关键词: Address; Adherence; Administrative Supplement; Adult; Affect; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; American; Attention; Big Data; Caregivers; Caring; Chronic; Chronic Disease; Clinical; Clinical Practice Guideline; Clinics and Hospitals; Code; Cognition; Communication; Data; Data Set; Dementia; Development; Diagnosis; Disease; Disease Management; Drug Interactions; Elderly; Electronic Health Record; Emergency department visit; Equilibrium; Equipment and supply inventories; Ethnic Origin; Family Caregiver; Frequencies; Funding; Goals; Guidelines; Health; Health Care Costs; Healthcare; High Prevalence; Hospitalization; Individual; Infrastructure; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Intervention; Iowa; Knowledge; Lead; Literature; Measures; Mental Depression; Modeling; Outcome; Pain; Pain Measurement; Pain management; Pain quality; Parents; Patient risk; Patient-Focused Outcomes; Patients; Pattern; Pharmaceutical Preparations; Policies; Polypharmacy; Population; Provider; Quality of life; Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Science; Subgroup; Symptoms; Techniques; Testing; Treatment outcome; Universities; advanced analytics; base; big-data science; biobehavior; care outcomes; care providers; clinical development; clinically relevant; experience; health care service utilization; improved; individualized medicine; medical specialties; mortality; multiple chronic conditions; parent grant; patient health information; patient subsets; profiles in patients; programs; psychological distress; response; sex; side effect; symptom science; treatment responders

Project Summary/Abstract – Parent Study The parent study to this application is the Center for Advancing Multimorbidity Science (CAMS, P20 NR018081-01, PI: Gardner and Rakel). Many people with chronic disease have more than one chronic condition, which is referred to as multimorbidity (multiple chronic conditions: MCC). Patients with MCC have worse health outcomes, including decreased functioning and quality of life as well as greater depression, psychological distress, and mortality. However, little data exist on MCCs risk and treatment profiles to provide direction for clinical practice guidelines development. The specific aims of the parent study are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. Project Summary/Abstract – Administrative Supplement There is very little in the literature on MCC patterns and their associated pain symptomology for patients with Alzheimer’s disease (AD). This supplemental study will investigate relationships among MCC, pain symptomology, healthcare utilization, and AD. We will leverage big data in a healthcare dataset to describe the most clinically relevant MCC patterns in patients with AD and to characterize the pain symptomology and healthcare utilization. The aims of this study are: 1. Identify and describe the most frequent, highly correlated, and clinically relevant patterns of co-occurring chronic conditions among AD patients. 2. Characterize healthcare utilization and pain symptomology for the MCC patient subgroups identified in Aim 1 and compare among the subgroups. 3. Investigate the relationships between healthcare utilization and pain symptomology and MCC subgroups. The results of this study will inform the prioritization of future research leading to clinical guidelines based on patient profiles that will optimize pain treatments and outcomes for patients with AD and MCC.

项目摘要/摘要 - 家长研究 该应用程序的家长研究是推进多种疾病科学的中心（CAM，， P20 NR018081-01，PI：Gardner和Rakel）。许多患有慢性疾病的人多于 一种慢性病，被称为多种疾病（多种慢性病： MCC）。 MCC患者的健康状况较差，包括功能降低和 生活质量以及更大的抑郁，心理困扰和死亡率。但是，很少 在MCC风险和治疗概况上存在数据，以为临床实践指南提供指导 发展。父母研究的具体目的是： 1。通过建立可持续的跨学科生物行为研究能力 并协调基础架构和资源，以促进集成 通过发展患者风险和 治疗响应者轮廓。 2。建立主题科学，首先是对多重科学的重新概念化 慢性病（多种疾病），包括症状科学。 3.启用研究将发展为新的科学计划和独立计划 研究人员研究应用。 项目摘要/摘要 - 行政补充 关于MCC模式及其相关疼痛症状的文献中，几乎没有 阿尔茨海默氏病（AD）患者。这项补充研究将调查关系 在MCC中，疼痛症状，医疗保健利用和AD。我们将利用大数据 医疗保健数据集描述AD患者和 表征疼痛症状和医疗保健利用。这项研究的目的是： 1。识别和描述最频繁，高度相关和临床相关的模式 AD患者共同出现的慢性病。 2。特征是MCC患者的医疗保健利用和疼痛症状 在AIM 1中确定的子组并在亚组之间进行比较。 3。研究医疗保健利用与疼痛症状与疼痛的关系与 MCC子组。 这项研究的结果将为未来研究的优先级列出，导致临床 基于患者特征的指南，可以优化患者的疼痛治疗和结果 与AD和MCC。