Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 9762982
• 负责人: SUE E GARDNER
• 金额: $ 37.51万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762982
• 关键词: Academy; Address; Adult; Algorithms; Area; Characteristics; Clinical; Common Data Element; Complex; Computer Simulation; Coupled; Custom; Data Analytics; Development; Diagnosis; Direct Costs; Discipline of Nursing; Disease; Faculty; Funding; Geriatric Nursing; Health; Healthcare; Hybrids; Individual; Infrastructure; Intervention; Iowa; Knowledge; Life Style; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; National Research Council; Outcome; Palliative Care; Patient risk; Patients; Persons; Pilot Projects; Population; Precision Health; Predisposition; Prevalence; Prevention; Preventive; Preventive Intervention; Research; Research Design; Research Personnel; Resources; Risk; Science; Scientist; Self Management; Signs and Symptoms; Strategic Planning; Subgroup; Symptoms; System; Taxonomy; Techniques; Therapeutic Intervention; Training; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; United States National Library of Medicine; Universities; University resources; Work; base; biobehavior; clinical decision-making; clinical practice; college; contextual factors; cost; disease classification; end of life; genetic makeup; individualized medicine; lens; multiple chronic conditions; precision medicine; preference; programs; skills; symptom cluster; symptom science; targeted treatment; treatment responders

The overall mission of the Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS) is to enhance interdisciplinary, biobehavioral research focused on complex multiple chronic conditions in human adult populations. Its specific purpose is to provide the infrastructure and resources to new investigators and their collaborators integrating two subfields: Multimorbidity Science and Symptom Science, characterizing risk susceptibility and treatment responder profiles using advanced analytic techniques. This will allow clinicians and scientists to identify persons who are more likely to develop specific conditions/symptoms as well as those who may respond to customized therapies. The specific aims of this Center are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. The Center includes 61 faculty and builds upon the research strengths of the faculty at the University of Iowa in symptom science and gerontological nursing (FY2018 research base is $1,118,436 in direct costs). In addition, it is embedded in a strong supportive interdisciplinary network of investigators and Centers from other University departments and Colleges. We will leverage exceptional University resources and complete proposed projects and activities to further the integrated hybrid area of Multimorbidity and Symptom Science. The Center aligns with three thematic areas of the 2016 NINR Strategic Plan: Symptom Science, Self-Management, End-of-Life and Palliative Care and supports the NINR Common Data Element (CDE) initiative.

推进多种病态科学中心的整体使命：分析风险和 症状表达以开发多种慢性病的成年人定制疗法 （CAM）是为了增强跨学科的生物行为研究，重点是复杂的多个慢性 人类人口的条件。 它的具体目的是向新调查人员及其提供基础设施和资源 合作者整合了两个子领域：多种病症科学和症状科学，表征风险 使用高级分析技术的敏感性和治疗响应者谱。这将允许 临床医生和科学家识别更有可能发展特定条件/症状的人 以及那些可以对定制疗法做出反应的人。该中心的具体目的是： 1。通过建立和 协调基础架构和资源，以促进多发性和 症状科学通过发展患者风险和治疗响应者概况。 2。建立主题科学，首先是对多个慢性科学的重新概念化 条件（多种病），包括症状科学。 3.启用研究将发展为新的科学计划和独立研究者 研究应用。 该中心包括61位教职员工，并建立在大学的研究优势的基础上 爱荷华州症状科学和老年医学护理（2018财年研究基础为1,118,436美元 费用）。此外，它嵌入了强大的支持性跨学科网络中， 来自其他大学系和大学的中心。我们将利用卓越的大学 资源和完成拟议的项目和活动，以进一步促进 多种症状和症状科学。该中心与2016年NINR的三个主题区域保持一致 战略计划：症状科学，自我管理，临终关怀和姑息治疗，并支持 NINR公共数据元素（CDE）倡议。