Membrane-Acting Peptides

膜作用肽

• 批准号: 10114789
• 负责人: JUN F LIANG
• 金额: $ 46.26万
• 依托单位: STEVENS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10114789
• 关键词: Affect; Antifungal Agents; Antiviral Agents; Apoptosis; Binding; Biological; Biological Assay; Biological Process; Cell Communication; Cell Culture Techniques; Cell membrane; Cell surface; Cells; Charge; Coculture Techniques; Computer Simulation; Confocal Microscopy; Cultured Cells; Cytolysis; Development; Disease; Endocrine; Growth Factor; Health; Human; In Vitro; Left; Ligands; Membrane; Membrane Potentials; Methods; Modernization; Names; Natural Selections; Nature; Neurotransmitters; Organism; Paracrine Communication; Peptide Signal Sequences; Peptides; Pharmaceutical Chemistry; Pharmacologic Substance; Physiological Processes; Process; Property; Proteins; Research; Scanning Electron Microscopy; Series; Signal Transduction; Site; Stains; Structure; Surface; Technology; Testing; Therapeutic; advanced analytics; antimicrobial; base; cancer cell; cell growth; design; experimental study; improved; insight; interest; lead optimization; macromolecule; neglect; novel strategies; screening; self assembly; small molecule; tool

Membrane-Acting Peptides Bioactive peptides regulate many physiological processes, acting at some sites as endocrine or paracrine signals and at others as neurotransmitters or growth factors, have important and positive impacts on human health including antimicrobial, antifungal, antiviral, and antitumor activities. In this project, we will explore a new rationale design approach to membrane-acting peptides. We will: 1) design and develop new bioactive peptides based on on-membrane peptide assembly; 2) study the biological implications of peptides in vitro; 3) evaluate the pharmaceutical significance of promising peptides on disease cells and co-cultures.

膜作用肽 生物活性肽调节许多生理过程，在某些部位作用于内分泌或旁分泌 信号和其他作为神经递质或生长因素的信号，对人具有重要的积极影响 健康，包括抗菌，抗真菌，抗病毒和抗肿瘤活性。在这个项目中，我们将探索 一种用于膜作用肽的新理由设计方法。我们将：1）设计和开发新的生物活性 基于膜上肽组件的肽； 2）研究肽在体外的生物学意义； 3） 评估有希望的肽对疾病细胞和共培养的药物意义。