Engineered Intravascular Catheters for the Treatment of Bacteremia

用于治疗菌血症的工程血管内导管

• 批准号: 8676368
• 负责人: JUN F LIANG
• 金额: $ 18.75万
• 依托单位: STEVENS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-10 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676368
• 关键词: Adhesions; Affect; Animal Model; Animals; Antibiotic Resistance; Antibiotics; Autolysis; Bacteremia; Bacteria; Blood Vessels; Catalysis; Catheters; Cell membrane; Cells; Charge; Chemistry; Clinical; Complication; Critical Illness; Devices; Diagnosis; Effectiveness; Engineering; Excision; Exhibits; Feedback; Genetic; Goals; Hemodialysis; Heparin; Hospitalization; Hour; Hydrolysis; Hydrophobicity; Image; Implantable venous access port; Incubated; Infection; Infection prevention; Life; Mechanics; Methods; Modification; Morbidity - disease rate; Nature; Patients; Peripheral; Phase; Phospholipids; Polyethylene Glycols; Property; Research; Resistance; Resistance Process; Silicon; Site; Staphylococcus aureus; Surface; Suspension substance; Suspensions; Testing; Time; Venous; Work; antimicrobial; bactericide; base; catalyst; catheter related infection; controlled release; cost; design; engineering design; methicillin resistant Staphylococcus aureus; mutant; prevent; public health relevance

DESCRIPTION (provided by applicant): Engineered Intravascular Catheters for the Treatment of Bacteremia Most patients undergo intravascular catheter placement at some time during their hospitalization, Ensuing infection is the most common complication associated with intravascular devices and subsequent bacteremia can be a highly morbid and oftentimes lethal consequence. In this project, we will apply the principle of phase-boundary catalysis in catheter design and test ability of engineered intravascular catheters in preventing infections and treatment of bacteremia on animal models.

描述（由申请人提供）：用于治疗细菌血症的工程性血管内导管，大多数患者在住院期间的某个时候接受了血管内导管的放置，随之而来的感染是与血管内器件和随后的菌血症有关的最常见并发症，可能是一种高度厌恶的和经常发生的尸体。在这个项目中，我们将在导管设计和激活血管内导管的测试能力中应用相结合催化的原理，以防止动物模型上的感染和治疗菌血症。