Bone Metabolism in Adolescents UndergoingBariatric Surgery

接受减肥手术的青少年的骨代谢

基本信息

批准号：
10115703
负责人：
Miriam Antoinette Bredella
金额：
$ 18.99万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115703
关键词：
Accounting Address Adipose tissue Adolescent Adolescent obesity Adrenal Glands Adult Androgens Anorexia Nervosa Award Biomechanics Body Composition Bone Density Bone Resorption Charge Childhood Clinical Clinical Investigator Clinical Research Clinical and Translational Science Awards Complex Development Distal Dual-Energy X-Ray Absorptiometry Endocrine Endocrinology Environment Estrogens Faculty Fatty acid glycerol esters Female Adolescents Finite Element Analysis Foundations Functional Imaging Funding Future Gastrectomy Gastric Bypass General Hospitals Goals Grant Growth Disorders Hip Fractures Hip region structure Impairment Institution Insulin Insulin-Like Growth Factor I Intervention Investigation Investigative Techniques Joints Lead Leadership Magnetic Resonance Imaging Male Adolescents Marrow Massachusetts Mediating Mentors Metabolic Metabolism Mid-Career Clinical Scientist Award (K24)Mission Modeling Morbid Obesity Musculoskeletal National Institute of Diabetes and Digestive and Kidney Diseases Non obese Obesity Osteogenesis Outcomes Research Patients Peer Review Peer Review Grants Peripheral Physiological Positioning Attribute Procedures Publications Radial Radiology Specialty Research Research Peer Review Research Personnel Research Project Grants Research Support Resources Risk Risk Estimate Site Somatotropin Spinal Fractures Structure Techniques Thinness Time Training Translational Research United States National Institutes of Health Vertebral column Weight-Bearing state Work bariatric surgery base bone loss bone metabolism bone strength bone turnover cardiometabolic risk career catalyst experience falls fracture risk ghrelin innovation interest medical schools medical specialties metabolic imaging mid-career faculty muscle form musculoskeletal imaging novel novel imaging technique nutrition patient oriented research programs prospective radiologist skeletal soft tissue subcutaneous synergism tibia training opportunity

项目摘要

Project Summary/Abstract The applicant, Miriam Bredella MD, is a clinically active staff radiologist in the Division of Musculoskeletal Imaging and Interventions at the Massachusetts General Hospital and an Associate Professor of Radiology at Harvard Medical School. Over the last 11 years Dr. Bredella’s research has focused on advanced functional imaging techniques investigating mechanisms of bone loss in obesity. Her prior mentoring experience, publication and funding record together with her current and planned research support demonstrate her commitment and passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives of the K24 Award. The specific aims addressing the purpose of the K24 Award are: 1) To enable Dr. Bredella to dedicate 50% of her time to mentor junior clinical investigators based on her already NIH funded R01 grant on bone metabolism in adolescents undergoing bariatric surgery; 2) To mentor junior clinical investigators from the Endocrine and Radiology Departments and other specialties interested in metabolic research, investigators from the T32 program in Nutrition and Metabolism, and the pool of residents and fellows in Endocrinology and Radiology with the goal to develop them into clinical researchers who can successfully compete for peer-reviewed grants related to the mission of the NIDDK; and 3) To enable Dr. Bredella to further establish a patient-oriented research program that combines innovative translational, clinical, and outcomes research in metabolic imaging and that provides an ideal environment to develop future leaders in clinical research. The training environment at the PI's institution is outstanding in terms of didactic resources and availability of techniques to assess complex metabolic endpoints. Importantly, Dr. Bredella enjoys strong commitment from the leadership of both Endocrinology and Radiology who have enthusiastically endorsed her successful mentoring efforts to date and the plans in the current proposal. The specific research aims of the application are based on the candidate’s successfully funded R01, investigating in morbidly obese adolescent boys and girls undergoing Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) 1) whether areal and volumetric BMD and strength estimates by finite element analysis (FEA) will decrease, and cortical and trabecular microarchitecture will be impaired whereas marrow adipose tissue (MAT) will increase and bone resorption markers will exceed those of bone formation markers and 2) investigating novel physiologic mechanisms mediating skeletal changes after RYGB and VSG. New directions proposed in the current application will estimate risk of fracture after RYGB and VSG by using a novel, biomechanically-based approach that encompasses both bone strength (by FEA) and skeletal loading (by musculoskeletal modeling), thereby accounting for extreme changes in body composition that influence fracture risk.

项目摘要/摘要申请人Miriam Bredella医学博士是肌肉骨骼分区的临床活跃的射线科医生马萨诸塞州综合医院的成像和干预措施和放射学副教授哈佛医学院。在过去的11年中，Bredella博士的研究集中于高级功能成像技术研究了肥胖症中骨质流失的机制。她先前的心理经历，出版和资金记录以及她当前和计划的研究支持证明了她对以患者为导向的研究的承诺和热情，并为完成 K24奖的目标和目标。解决K24奖项目的的具体目的是：1）使Bredella博士能够将她的50％的时间用于基于NIH的精神少年临床研究者在接受减肥手术的青少年中资助了R01骨骼代谢的赠款； 2）到精神少年临床内分泌和放射学部门以及其他对代谢感兴趣的专业的研究人员研究，T32营养和新陈代谢计划的研究人员，以及居民的库内分泌学和放射学的研究员的目标是将其发展为临床研究人员成功竞争了与Niddk的任务有关的同行评审的赠款； 3）启用博士 Bredella进一步建立了一个以患者为导向的研究计划，该计划结合了创新的翻译，临床和代谢成像的结果研究，这为发展未来提供了理想的环境临床研究领导者。 PI机构的培训环境在教学方面非常出色资源和技术的可用性评估复杂的代谢终点。重要的是，布雷德拉博士从热情洋溢的内分泌学和放射学的领导中享有坚定的承诺认可了她迄今为止成功的心理努力以及当前提案中的计划。具体研究该申请的目的是基于候选人成功资助的R01，对病态肥胖进行调查青春期男孩和女孩正在接受roux-en-y胃旁路（RYGB）或垂直套管切除术（VSG） 1）面积和体积BMD和通过有限元分析（FEA）的强度估计是否会减少，皮质和小梁微体系结构将受到损害，而骨髓脂肪组织（MAT）将增加和骨骼分辨率标记将超过骨形成标记的标记，2）研究新颖 RYGB和VSG后介导骨骼变化的生理机制。在当前的应用将通过使用新颖的，基于生物力学的方法来估计RYGB和VSG后骨折的风险包括骨骼强度（通过FEA）和骨骼载荷（通过肌肉骨骼建模）的方法，从而考虑了影响断裂风险的人体组成的极端变化。