Biobanking and Biomarker Validation (BBV) Core

生物样本库和生物标志物验证 (BBV) 核心

基本信息

批准号：
10115115
负责人：
ANDREW K. GODWIN
金额：
$ 22.21万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115115
关键词：
Accreditation Area B-Lymphocytes BRAF gene Benign Biological Assay Biological Markers Biological Specimen Banks Biomedical Engineering Biomedical Research Blood Blood specimen CLIA certified Cancer Center Caring Cell Line Cells Centers of Research Excellence Clinical Clinical Research Clinical Trials Collection Communities Core Facility Custom DNA Development Diagnosis Disease Ensure Enzyme-Linked Immunosorbent Assay Epidermal Growth Factor Receptor Evaluation Event FLT3 gene Faculty Family history of Fostering Fresh Tissue Funding Future Genes Genomic DNA Genomics Goals Healthcare Histology Human Immunoassay Immunohistochemistry Individual Informed Consent Infrastructure Institutes Interdisciplinary Study Intervention Irrigation JAK2 gene KRAS2 gene Kansas Laboratories Length Liquid substance Malignant Neoplasms Measurement Medical center Messenger RNA Methylation MicroRNAs Microsatellite Instability Mission Molecular Molecular Diagnostic Testing Mutation Analysis Nose Nucleic Acids Participant Pathologic Patients Plasma Pleural Population Precision Medicine Initiative Proteins Research Research Personnel Residual Neoplasm Resources Role Saliva Sampling Science Serum Services Somatic Mutation Specimen T cell clonality Technical Expertise Testing Tissue Stains Tissues Universities Urine Western Blotting Whole Blood Work active duty base bcr-abl Fusion Proteins biobank biomarker development biomarker discovery biomarker validation cell free DNA cost effective design exosome extracellular vesicles genetic signature human leukocyte antigen testing improved improved outcome innovation lifestyle factors malignant breast neoplasm molecular diagnostics molecular oncology next generation sequencing personalized care pre-clinical precision medicine prognostic programs promoter relative cost repository research clinical testing research study success telomere

项目摘要

COBRE Kansas Institute for Precision Medicine (KIPM) – “Biobanking and Biomarker Validation Core” ABSTRACT The overall objective of the “Kansas Institute for Precision Medicine” (KIPM) COBRE at the University of Kansas Medical Center (KUMC) is to advance the customization of healthcare through promoting innovative scientific discoveries. We have entered the era of Precision Medicine, an initiative recently announced as part of the 21st Century Cures Act, which is focused on using the molecular basis of diseases to better match patients with the appropriate therapies and care resulting in improved outcomes. To advance this mission, we have established the Biobanking and Biomarker Validation (BBV) Core, which combines exceptional expertise and essential resources within established infrastructure, i.e., Biospecimen Repository Core Facility (BRCF), the Biomarker Discovery Laboratory (BDL), and the Clinical Molecular Oncology Laboratory (CMOL). Access to the BBV core will strengthen the biomedical research capacity of our COBRE faculty by enhancing their research base and infrastructure capacities. To advance precision medicine research within this COBRE, the BBV core will 1) Provide centralized and uniform collections, processing, and storage of tissue and bodily fluids and tissue-related histology services; 2) provide integral and comprehensive protein and nucleic acid isolation, quantitation, and molecular characterization services; and 3) provide fully customizable molecular testing and genomic-based sequencing services. The BBV core is designed to centralize these essential services that will in turn provide support to the KIPM COBRE faculty, pilot grantees, and researchers within our region and beyond. Given the level of sophistication of the materials and services required for the range of studies proposed within the KIPM COBRE, a highly integrated BBV core is not only cost effective but an absolute necessity. The BBV core eliminates redundant infrastructure and expense required for each researcher to develop their own capabilities or to search for the necessary research expertise. The BBV core will enable multiple COBRE faculty and future pilot grantees, access to state-of-the-art facilities and laboratory expertise, thereby further reducing the relative cost of their studies. Furthermore, the BBV core will continue to provide in-kind technical staff-support and banking resources, which help the KIPM COBRE faculty to more effectively utilize their funding, both institutional startup and COBRE support. The success of the BBV core and ultimately the COBRE faculty is essential to advancing the mission of the KIPM to advance the customization of healthcare through promoting innovative scientific discoveries.

堪萨斯州柯布尔精密医学研究所（KIPM） - “生物群和生物标志物验证核心” 抽象的堪萨斯大学的“堪萨斯州精密医学研究所”（KIPM）的总体目标医疗中心（KUMC）将通过促进创新的科学来推进医疗保健的定制发现。我们进入了Precision Medicine时代，这是一项倡议，最近作为21日的一部分宣布 Century Cures Act，专注于使用疾病的分子基础来更好地匹配患者适当的疗法和护理可改善结果。为了促进这项任务，我们已经建立了结合了杰出专家和必不可少的生物群和生物标志物验证（BBV）核心建立的基础架构中的资源，即生物标志物生物标志物（BRCF）的生物测试存储库设施（BRCF）发现实验室（BDL）和临床分子肿瘤实验室（CMOL）。访问BBV核心通过加强他们的研究基础和基础设施能力。为了促进此毛绒内的精确医学研究，BBV核心将1）提供集中和均匀的收集，组织和身体流体以及与组织相关的储存组织学服务； 2）提供积分和全面的蛋白质和核酸分离，定量和分子表征服务； 3）提供完全可定制的分子测试和基于基因组的测试测序服务。 BBV核心旨在集中这些基本服务，然后将提供支持我们地区及以后的KIPM Cobre教职员工，飞行员授予者和研究人员。鉴于 KIPM中提出的一系列研究所需的材料和服务的复杂水平高度集成的BBV核心Cobre不仅具有成本效益，而且是绝对必要的。 BBV核心消除每个研究人员开发自己功能所需的冗余基础架构和费用或寻找必要的研究专业知识。 BBV核心将启用多个毛茸茸的教职员工和未来飞行员大人，获得最先进的设施和实验室专业知识，从而进一步降低了亲戚他们的学习成本。此外，BBV核心将继续提供实物技术人员支持和银行资源，帮助KIPM COBRE教师更有效地利用其资金，这两个机构都是机构启动和毛绒支持。 BBV核心的成功以及最终的山cor教师至关重要推进KIPM的使命，通过促进创新来推进医疗保健的定制科学发现。