The Kansas Institute for Precision Medicine

堪萨斯精准医学研究所

• 批准号: 10582647
• 负责人: ANDREW K. GODWIN
• 金额: $ 224.19万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10582647
• 关键词: Address; Advisory Committees; Applied Research; Area; Basic Science; Biomedical Engineering; Biomedical Research; Cancer Center; Caring; Centers of Research Excellence; Characteristics; Clinic; Clinical; Collaborations; Communities; Department chair; Development; Diagnosis; Diagnostic; Diet; Discipline; Disease; Education; Environment; Evolution; Faculty; Family; Fostering; Funding; Generations; Goals; Healthcare; Individual; Infrastructure; Institution; Internal Medicine; Kansas; Knowledge; Laboratories; Leadership; Life Style; Medical; Medical History; Medical center; Medicine; Mentors; Methods; Mission; Molecular; Molecular Medicine; Molecular Profiling; Outcome; Participant; Pathology; Patient Care; Patient-Focused Outcomes; Patients; Peer Review; Persons; Physicians; Precision therapeutics; Process; Program Sustainability; Public Health; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Sharing; Rural; Science; Scientist; Seasons; Secure; Shapes; Training; Training Programs; Translating; Translational Research; Universities; base; biobank; biomarker development; biomarker validation; clinical care; clinical practice; disparity gap; experience; human disease; implementation barriers; improved; individualized medicine; innovation; insight; invention; medical schools; meetings; molecular marker; next generation; novel diagnostics; organizational structure; personalized diagnostics; population health; precision medicine; programs; recruit; standard of care; tool; translational physician; translational scientist

ABSTRACT The overall objective of the “Kansas Institute for Precision Medicine” (KIPM) COBRE at the University of Kansas Medical Center (KUMC) is to advance the customization of healthcare through promoting innovative scientific discoveries. The KIPM COBRE will provide support to advance the mission of KUMC through innovative mentoring and training programs with a precision medicine theme. The KIPM COBRE will also strengthen the biomedical research capacity within our region by enhancing the research base and infrastructure/core capacities. To accomplish this, the KIPM COBRE proposes the following Specific Aims: Specific Aim 1. Recruit and mentor a group of outstanding junior investigators in diverse disciplines with different disease focus areas that have a common theme directed toward precision medicine. In a rigorous pre-selection process, five promising junior investigators (and two alternative investigators) were selected from nearly 20 applicants, all of which had a research theme directly related to precision medicine. Decisions were based on the content of research proposals and training potential that were evaluated by our leadership team (including the three PIs of the proposed COBRE, the senior leadership at KUMC including the Dean, department chairs, and past PIs of COBREs within KUMC). Each applicant has been assigned at least one internal and one external mentor with expertise related to their area of study. All COBRE faculty candidates contributed to discussions regarding infrastructure necessary to enhance their projects via one-on-one meetings with the PIs and research core directors were formed based in infrastructure needs to enhance their research capacity. Specific Aim 2. To develop the scientific, technical, mentoring and collaborative infrastructure for a cohesive and sustainable program in precision medicine. Relying on additional expertise afforded by our Internal Advisory Committee (IAC), the External Advisory Committee (EAC), and an interactive mentoring program, we will continue to guide and mentor the next generation of translational scientists to advance molecular medicine in the 21st century with a thematic focus on precision medicine. Four shared resources, i.e., Administrative, Biomedical Engineering (BME), Biobanking and Biomarker Validation (BBV), and Quantitative `Omics' (QO) Cores, will be developed to assist the projects and serve the extended research community in Kansas and beyond. Specific Aim 3. To foster and enhance collaborations between basic scientists and clinicians and facilitate translational research directed toward the development of biomarkers, new diagnostics and/or treatments for human disease. Pilot research projects funded by the School of Medicine, the Departments of Internal Medicine and Pathology and Laboratory Medicine, and the NCI-designated KU Cancer Center, will provide opportunities to identify both senior and junior investigators within our institute to expand the breadth and depth of research in the fields of precision medicine.

抽象的 堪萨斯大学的“堪萨斯州精密医学研究所”（KIPM）的总体目标 医疗中心（KUMC）将通过促进创新的科学来推进医疗保健的定制 发现。 KIPM Cobre将提供支持，以通过创新来推进KUMC的任务 具有精确医学主题的指导和培训计划。 kipm毛绒也将加强 通过增强研究基础和基础设施/核心的生物医学研究能力 能力。为此，kipm cobre提出以下特定目的：特定目的1。招募 并指导一群在不同疾病重点领域的潜水学科中的杰出初级研究人员 具有针对精确医学的共同主题。在严格的预选过程中，五个 从近20名申请人中选择了有前途的初级调查人员（和两名替代调查人员） 该研究主题与精密医学直接相关。决定基于内容 我们的领导团队评估的研究建议和培训潜力（包括 拟议的毛绒，KUMC的高级领导，包括院长，部门主席以及过去的PIS KUMC中的cobres）。每个申请人至少被分配了一个内部和一个外部心理 与他们的学习领域有关的专业知识。所有的索布雷教师候选人都为有关讨论的讨论做出了贡献 通过与PIS和研究核心的一对一会议来增强其项目所需的基础设施 基于基础设施的董事是建立的，以增强其研究能力。特定目标2。 开发科学，技术，心理和协作基础架构，以凝聚力和可持续性 精密医学计划。依靠我们内部咨询委员会提供的其他专业知识 （IAC），外部咨询委员会（EAC）和互动心理计划，我们将继续指导 并指导下一代的转化科学家，以在21世纪推进分子医学 主题关注精确医学。四个共享资源，即行政，生物医学工程 （BME），生物群和生物标志物验证（BBV）以及定量的“ OMICS”（QO）核心将开发为 协助项目并为堪萨斯州及其他地区的扩展研究社区服务。特定目标3。 促进并增强基础科学家与临床医生之间的合作，并促进转化研究 致力于开发生物标志物，新诊断和/或人类疾病治疗方法。飞行员 医学院，内科和病理学系资助的研究项目以及 实验室医学和NCI指定的KU癌症中心将提供机会确定两者 和我们研究所内的初级调查人员，以扩大精确领域的研究广度和深度 药品。