Changes across the lifespan in the use of heuristics to guide decision-making

使用启发式方法指导决策的整个生命周期的变化

基本信息

批准号：
10115564
负责人：
Michele A Basso
金额：
$ 71.18万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2021-10-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115564
关键词：
Age Aging Alzheimer&apos s Disease Animal Model Attention Bayesian Analysis Behavior Behavioral Model Brain Cognitive Data Decision Making Degenerative Disorder Dementia with Lewy Bodies Development Discrimination Disease Economics Elderly Evaluation Foundations Future Health Human Impaired cognition Impairment Individual Injections Laboratories Learning Lewy Body Variant of Alzheimer&apos s Disease Longevity Modeling Monkeys Motivation Motor Nerve Degeneration Neurobehavioral Manifestations Neurodegenerative Disorders Neuropharmacology Outcome Parkinson Disease Parkinson&apos s Dementia Performance Process Psychological reinforcement Research Rewards Risk Scientific Inquiry Sensory Tauopathies Testing Time TimeLine Variant Visual Work age related age related neurodegeneration aged alpha synuclein base design experimental study falls heuristics human disease knowledge base millisecond model development neural circuit neurochemistry neuronal circuitry novel pre-formed fibril processing speed relating to nervous system sensory neuroscience sound synuclein synucleinopathy young adult

项目摘要

PROJECT SUMMARY Decision-making operates over vastly different temporal scales. Although perceiving a sound requires information gathered over a time span of just milliseconds, deciding whom to marry may require years. Decision- makers also change over time. As we age, our perceptual and motor processing abilities change but also our knowledge base, our motivations and our comfort with risk change, all factors that contribute to our decisions. Recent work indicates that older adults may rely more on heuristics to inform their decisions, compared to younger adults. Conversely, we recently discovered that people with Parkinson’s disease, one of several related neurodegenerative proteinopathies falling along a continuum of alpha-synuclein and tauopathy that includes Alzheimer’s disease and variants of these two diseases, are impaired in the use of previously learned information (priors or heuristics) to guide perceptual decisions. Together these results indicate that the ability to use prior information for decisions changes over the lifespan and with diseases associated with aging. It is unknown how the use of priors or heuristics for perceptual decision-making develops or changes over the lifespan. It is equally unknown how the ability to use heuristics for decision-making is impaired with aging or neurodegenerative disease. Therefore, we propose to develop a novel animal model of decision-making behavior over the lifespan to test the hypothesis that the use of heuristics for decision-making differs between young and old and those with age-related proteinopathy and neurodegeneration. The results of our proposed experiments will provide a timeline of decision-making changes in a novel animal model of aging in health and disease. The results will provide the groundwork for future experiments designed to unravel the neural circuitry and neuropharmacology underlying decision-making changes over the lifespan and with age-related proteinopathies along the synuclein- tauopahy continuum, including Alzheimer’s disease, Parkinson’s disease and variants of these diseases, and thus facilitate the development of novel treatments for cognitive impairment associated with these diseases.

项目摘要决策在暂时的暂时尺度上有很大的时间。信息在毫秒的时间范围内收集，决定结婚的人可能需要多年的决定。随着我们的年龄，我们的感知和运动处理的余量，制造商也会随着时间的流逝而改变知识基础，我们的动机以及我们对风险变化的舒适感，这是所有有助于我们决策的因素。最近的工作表明，与他们的决定相比年轻的成年人。神经退行性蛋白质病沿着α-突触核蛋白和陶氏症的连续性包括在内阿尔茨海默氏病和两种疾病的变体在使用时受到损害（先验或启发式方法）指导这些结果。决策的信息在整个寿命中发生变化，并与衰老有关。在整个生命周期内，使用先验或启发式方法会发展或变化。尚不清楚如何使用启发式方法进行决策的能力与衰老或神经退行性相关。因此，我们建议在整个生命周期中发展出新的决策行为模型为了检验以下假设，即使用使用使用使用使用的使用情况不同随着年龄的蛋白质病和神经退行性的影响。在健康和疾病中衰老的新动物模型的决策时间线。为未来的实验提供基础，旨在揭示神经回路和神经药理寿命中的潜在决策变化以及与突触核蛋白的蛋白质病有关陶氏连续，包括阿尔茨海默氏病，帕金森氏病和疾病的变体和疾病因此，通过这些疾病促进了对认知障碍的新疗法的发展。