Changes across the lifespan in the use of heuristics to guide decision-making

使用启发式方法指导决策的整个生命周期的变化

基本信息

批准号：
10589139
负责人：
Michele A Basso
金额：
$ 81.71万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10589139
关键词：
Age Aging Alzheimer&apos s Disease Animal Model Attention Bayesian Analysis Behavior Behavioral Model Brain Cognitive Data Decision Making Degenerative Disorder Dementia with Lewy Bodies Development Discrimination Disease Economics Elderly Evaluation Experimental Designs Foundations Future Health Human Impaired cognition Impairment Individual Injections Laboratories Learning Lewy Body Variant of Alzheimer&apos s Disease Longevity Modeling Monkeys Motivation Motor Nerve Degeneration Neurobehavioral Manifestations Neurodegenerative Disorders Neuropharmacology Outcome Parkinson Disease Parkinson&apos s Dementia Performance Persons Process Psychological reinforcement Research Rewards Risk Scientific Inquiry Sensory Tauopathies Testing Time Variant Visual Work age related age related neurodegeneration aged alpha synuclein design experimental study falls heuristics human disease information gathering knowledge base millisecond model development neural neural circuit neurochemistry neuronal circuitry novel pre-formed fibril processing speed sensory neuroscience sound synuclein synucleinopathy timeline young adult

项目摘要

PROJECT SUMMARY Decision-making operates over vastly different temporal scales. Although perceiving a sound requires information gathered over a time span of just milliseconds, deciding whom to marry may require years. Decision- makers also change over time. As we age, our perceptual and motor processing abilities change but also our knowledge base, our motivations and our comfort with risk change, all factors that contribute to our decisions. Recent work indicates that older adults may rely more on heuristics to inform their decisions, compared to younger adults. Conversely, we recently discovered that people with Parkinson’s disease, one of several related neurodegenerative proteinopathies falling along a continuum of alpha-synuclein and tauopathy that includes Alzheimer’s disease and variants of these two diseases, are impaired in the use of previously learned information (priors or heuristics) to guide perceptual decisions. Together these results indicate that the ability to use prior information for decisions changes over the lifespan and with diseases associated with aging. It is unknown how the use of priors or heuristics for perceptual decision-making develops or changes over the lifespan. It is equally unknown how the ability to use heuristics for decision-making is impaired with aging or neurodegenerative disease. Therefore, we propose to develop a novel animal model of decision-making behavior over the lifespan to test the hypothesis that the use of heuristics for decision-making differs between young and old and those with age-related proteinopathy and neurodegeneration. The results of our proposed experiments will provide a timeline of decision-making changes in a novel animal model of aging in health and disease. The results will provide the groundwork for future experiments designed to unravel the neural circuitry and neuropharmacology underlying decision-making changes over the lifespan and with age-related proteinopathies along the synuclein- tauopahy continuum, including Alzheimer’s disease, Parkinson’s disease and variants of these diseases, and thus facilitate the development of novel treatments for cognitive impairment associated with these diseases.

项目摘要在较大的临时量表上进行决策操作。虽然认为声音需要信息收集的时间跨度仅为毫秒，决定结婚可能需要数年。决定- 制造商也随时间变化。随着年龄的增长，我们的感知和运动处理能力也会改变知识基础，我们的动机以及我们对风险变化的舒适感，这是所有有助于我们决策的因素。最近的工作表明，与老年人相比年轻人。相反，我们最近发现帕金森氏病的人，是几种相关的人之一神经退行性蛋白质病沿着α-突触核蛋白和陶氏症的连续性包括在内这两种疾病的阿尔茨海默氏病和变体在使用先前学习的信息时受到损害（先验或启发式方法）指导知觉决定。这些结果在一起表明使用先验的能力决策的信息随着寿命的变化以及与衰老相关的疾病的变化。这是未知的在整个生命周期内，使用先验或启发式方法来进行感知决策的发展或变化。它同样未知如何使用衰老或神经退行性的启发式方法来损害决策的能力疾病。因此，我们建议在整个生命周期内开发一种新型的决策行为动物模型检验以下假设，即启发式方法在年轻人和年轻人之间有所不同与年龄相关的蛋白质病和神经变性。我们提出的实验的结果将提供决策的时间表变化了健康和疾病衰老的新动物模型。结果将为未来的实验提供了基础，该实验旨在揭示神经元电路和神经药理学在整个生命周期中的潜在决策变化以及沿Synclein-与年龄相关的蛋白质病的变化 - 陶氏连续体，包括阿尔茨海默氏病，帕金森氏病和这些疾病的变体，因此，为与这些疾病相关的认知障碍的新疗法做好了准备。