JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

基本信息

批准号：
10079305
负责人：
ALEX L KOLODKIN
金额：
$ 15.56万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10079305
关键词：
3-Dimensional Address Alleles Amyotrophic Lateral Sclerosis Brain CRISPR screen Cells Cellular Morphology Clinical Clustered Regularly Interspaced Short Palindromic Repeats Collection Communities Complement Core Facility Custom Data Set Deletion Mutation Development Disease Dyes Epitopes Excitatory Synapse Fiber Optics Funding Gene Targeting Generations Genes Genetic Goals Grant Health Hippocampus (Brain)Image Imaging technology In Situ Individual Integrase Investigation Ions Light LoxP-flanked allele Microscope Mission Molecular Monitor Morphology Mus Mutagenesis National Institute of Neurological Disorders and Stroke Nerve Degeneration Nervous system structure Neuronal Injury Neurons Neurosciences Neurosciences Research Pain Parkinson Disease Physiologic Monitoring Protein Dynamics Proteins Pruritus Regulation Research Research Personnel Research Project Grants Research Support Resolution Resources Rodent Scanning Services Signal Transduction Sleep Source Stroke Technology Therapeutic Time Training Transgenic Mice Universities Work adult neurogenesis autism spectrum disorder awake base cellular engineering clinically relevant embryonic stem cell fluorescence imaging fluorophore imaging platform in vivo medical schools mouse genetics mouse model multiphoton imaging neuropsychiatric disorder programs protein protein interaction ranpirnase sperm cryopreservation transcription activator-like effector nucleases two-photon

项目摘要

SUMMARY: JHU Center for Neuroscience Research In this revised competitive renewal of our “JHU Center for Neuroscience Research” NINDS P30 center grant, we propose to both maintain and expand two of the Scientific Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that have anchored this Center for the past 10 years: the Multiphoton Imaging (MPI) Core and the Murine Mutagenesis Core (MMC; formally “ES Cell Engineering Core”). These Scientific Cores currently provide critical research capabilities and resources that are impractical for neuroscience investigators to provide on their own but that greatly enhance efforts of individual research programs. The experimental opportunities and technical services offered by these Cores complement, but do not duplicate, other facilities available to NINDS-funded investigators at JHU SOM. Use of Center Cores will continue to benefit the 12 NINDS-funded research programs that constitute the Primary Center Investigators of this Center, and also other NINDS-funded and non-NINDS-funded investigators at JHU SOM. The research programs of the Primary Center Investigators address a wide range of significant unsolved questions central to the NINDS mission. These include basic neuroscience investigation into excitatory synapse dynamics and function, the organization of hippocampal place cell circuitry, definition of cortical circuits underlying somatosensation, establishment of local circuitry during adult neurogenesis, cellular and molecular mechanisms of pain and itch, and Ca++ signaling in Na channel regulation. Clinically relevant work encompasses the genetics and molecular underpinnings of stroke, Parkinson's Disease, amyotrophic lateral sclerosis, autism spectrum disorders, and sleep. The unique capabilities of Center Cores will continue to serve as a crucial resource for NINDS-funded investigators at JHU by extending the research capabilities of individual investigators and by serving as a focal point for dissemination and practical training in state-of-the art research approaches. Through these efforts, the JHU Center for Neuroscience Research will help establish new strategies for studying brain function in health and disease that will benefit the broader neuroscience community.

摘要：JHU神经科学研究中心在经过修订的“ JHU神经科学研究中心”的竞争更新中，Ninds P30中心赠款我们建议在约翰·霍普金斯大学维护和扩展两个科学核心设施在过去的10年中，医学院（JHU SOM）锚定了这个中心：多人成像（MPI）核心和鼠诱变核心（MMC；正式的“ ES细胞工程核心”）。这些科学核心目前提供关键的研究能力和资源，这些功能和资源是不切实际的神经科学调查人员独自提供，但大大加强了个人研究的努力程序。这些核心完成提供的实验机会和技术服务，但要做不复制，其他设施可用于JHU SOM的Ninds资助的调查员。使用中心芯将继续受益于12个由Ninds资助的研究计划，构成该中心，以及Jhu Som的其他Ninds资助和非Ninds资助的调查员。研究主要中心调查人员的计划解决了广泛的重大未解决问题 Ninds任务。这些包括对兴奋性突触动态的基本神经科学研究和功能，海马放置电池电路的组织，底层皮质电路的定义体质，成人神经发生过程中的局部电路，细胞和分子 Na通道调节中的疼痛和瘙痒机制以及Ca ++信号传导。临床相关的工作涵盖了中风的遗传学和分子基础，帕金森氏病，肌营养性后来硬化症，自闭症谱系障碍和睡眠。中心核心的独特功能将继续服务作为JHU的Ninds资助的研究人员的关键资源，扩展了研究能力个人调查人员，并作为传播和实践培训的焦点研究方法。通过这些努力，JHU神经科学研究中心将有助于建立研究健康和疾病中大脑功能的新策略将使更广泛的神经科学受益社区。

项目成果

期刊论文数量（36）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain.

DOI：
10.1038/nn.3390
发表时间：
2013-06
期刊：
NATURE NEUROSCIENCE
影响因子：
25
作者：
Hughes, Ethan G.;Kang, Shin H.;Fukaya, Masahiro;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.

GADD45A is a protective modifier of neurogenic skeletal muscle atrophy.

DOI：
10.1172/jci.insight.149381
发表时间：
2021-07-08
期刊：
JCI insight
影响因子：
8
作者：
Ehmsen JT;Kawaguchi R;Kaval D;Johnson AE;Nachun D;Coppola G;Höke A
通讯作者：
Höke A

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex.

DOI：
10.1038/s41593-018-0121-5
发表时间：
2018-05
期刊：
Nature neuroscience
影响因子：
25
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
通讯作者：
Bergles DE

Reducing l-lactate release from hippocampal astrocytes by intracellular oxidation increases novelty induced activity in mice.

DOI：
10.1002/glia.23960
发表时间：
2021-05
期刊：
Glia
影响因子：
6.2
作者：
Vaccari Cardoso B;Shevelkin AV;Terrillion C;Mychko O;Mosienko V;Kasparov S;Pletnikov MV;Teschemacher AG
通讯作者：
Teschemacher AG

N-Acetylcysteine increases corneal endothelial cell survival in a mouse model of Fuchs endothelial corneal dystrophy.