JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

• 批准号: 8217112
• 负责人: ALEX L KOLODKIN
• 金额: $ 81.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8217112
• 关键词: 3-Dimensional; Address; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Antibodies; Archives; Area; Biochemical; Cells; Center Core Grants; Clinical; Communities; Complement; Core Facility; Custom; Data Set; Development; Dyes; Equipment; Event; Filament; Funding; Gene Expression Regulation; Gene Targeting; Generations; Goals; Grant; Hybrids; Image; Individual; Injury; Institution; Instruction; Ions; Laboratories; Lasers; Mental disorders; Methodology; Microscope; Monitor; Mono-S; Monoclonal Antibodies; Mus; National Institute of Neurological Disorders and Stroke; Natural regeneration; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurology; Neurons; Neurosciences; Neurosciences Research; Noise; Oryctolagus cuniculus; Pain Origin; Pathology; Phosphorylation; Photons; Physiologic Monitoring; Physiologic pulse; Protein Dynamics; Proteins; Reagent; Recording of previous events; Research; Research Personnel; Resolution; Resources; Running; Scanning; Scientist; Sensory; Services; Signal Transduction; Source; Specificity; Structure; Synapses; Tertiary Protein Structure; Time; Training; Transgenic Mice; Universities; base; cellular engineering; clinically relevant; embryonic stem cell; fluorophore; glial cell development; image processing; improved; instrumentation; medical schools; member; mouse model; nervous system disorder; neurodevelopment; operation; painful neuropathy; particle; programs; protein function; protein protein interaction; ranpirnase; reconstruction; sperm cell; two-photon; voltage

In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDSfunded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology,a nd one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.

在我们机构中心核心拨款以支持神经科学研究的竞争性更新中，我们 建议在约翰·霍普金斯（Johns Hopkins）维护和扩展三个现有核心设施的运营 在此期间建立的大学医学院（JHU SOM） 中心赠款：多光子成像核，单克隆抗体核心和胚胎干细胞 工程核心。这些设施目前提供必要的资源并执行所需的服务 对于单个实验室而言，不切实际。这些核心设施的使用将继续 极大地使11名主要中心调查员以及其他其他的Ninds资助的研究计划受益 Ninds资助的JHU SOM的调查员通过提供对独特设备的访问，新的培训 方法和新试剂的开发。实验机会和技术服务 这三个核心提供的补充，但不复制，其他核心设施可用于Nindsfund Jhu Som的调查人员。十一位中心调查人员中有七个是 神经科学系，四个是神经病学系的成员，其中一名是 病理学系。主要中心调查人员的研究计划涉及尚未解决的问题 神经和神经胶质发育，突触结构和功能，感觉转导的问题， 和活性依赖性基因表达的调节。小学中心调查人员的具体目的 Ninds资助的研究计划解决了关键的临床问题，包括 神经系统疾病，受伤或变性后神经元再生的促进， 神经性疼痛的基础和神经退行性疾病的起源（阿尔茨海默氏症的痴呆症 和肌萎缩性侧索硬化症）。主要中心调查人员构成一个高度互动群体 有了无缝的协作研究历史。该中心的目标是增加现有 通过为这些调查人员和JHU SOM的其他由Ninds资助的研究人员提供研究计划， 该机构在其他地方无法使用的核心设施。