Small Animal Imaging

小动物成像

基本信息

批准号：
7695936
负责人：
JOHN D. HAZLE
金额：
$ 16.11万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-28 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7695936
关键词：
Advisory Committees Agreement Animals Archives Area Arts Award Benchmarking Bioluminescence Biomedical Engineering Blood Vessels Budgets Cancer Center Cancer Center Support Grant Castor Catheterization Chairperson Chemistry Collaborations Communities Complement Computer software Consultations Custom Data Data Analyses Databases Development Devices Diagnostic Imaging Diagnostic radiologic examination Diffusion Discipline Experimental Designs Faculty Fees Fluorescence Funding Gamma Cameras Grant Health Services Research Housing Human Resources IACUC Image Image Analysis Imagery Imaging Techniques Imaging technology Individual Institution Intubation Investments Laboratories Life Localized Malignant Neoplasm Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Maintenance Malignant Neoplasms Metabolic Mission Modality Names Nuclear Nuclear Magnetic Resonance Operative Surgical Procedures Optical Tomography Peer Review Personal Satisfaction Persons Physics Physiology Pilot Projects Policies Positioning Attribute Positron-Emission Tomography Price Protocols documentation Publications Publishing Qualifying Radiation Radiochemistry Radioisotopes Range Rate Recruitment Activity Research Research Personnel Resources Retirement Rodent Running S10 grant Safety Services System Tail Techniques Texas Time Tissues Tomography, Computed, Scanners Translational Research Ultrasonography Universities University of Texas M D Anderson Cancer Center Veins Vision X-Ray Computed Tomography anticancer research austin cancer imaging cone-beam computed tomography data acquisition density design digital experience image processing in vivo instrument instrumentation medical specialties member microsystems molecular imaging mortality optical imaging professor programs research facility research study single photon emission computed tomography software development spectroscopic imaging technology/technique technology/technique development

项目摘要

The Small Animal Cancer Imaging Research Facility (SACIRF) provides cancer investigators with the latest technology and techniques for experimental in vivo imaging of small animals. The facility includes state-ofthe- art instrumentation, including the modalities of magnetic resonance (MR, Bruker4.7 T, 40 cm Biospec), x-ray computed tomography (micro-CT from Enhanced Vision Systems and volume CT being developed in collaboration with General Electric), projection radiography (Faxitron), and nuclear imaging (M.Cam gamma camera from Siemens and micro-PET from Concorde Microsystems). Optical imaging will be added during the first year of the award (instrumentation to be developed in collaboration with Biomedical Engineering at The University of Texas-Austin). This instrumentation represents a >$3M investment by MDACC. The SACIRF has allocated space for the instruments in the animal support facilities to facilitate the inclusion of the imaging studies in ongoing cancer research, and dedicated office and developmental laboratory space to support the facility operation. The faculty and staff are well-qualified in each of the modality areas, including current image acquisition and image analysis techniques. Specialty areas include quantitative tissue characterization (MR), imaging of microvascular physiology (MR, nuclear, CT and optical), diffusion imaging for estimating cellular density (MR), metabolic imaging (nuclear, positron emission tomography [PET], optical and MR spectroscopy), and vascular imaging (MR, CT, and x-ray). The services of the facility include imaging protocol design, custom positioning systems, custom data acquisition hardware and software, image analysis, data archiving, provision of hardcopy and digital data delivery, and database maintenance. The Veterinary Core includes a dedicated support team that provides highly efficient imaging studies and a very low mortality rate of animals during the imaging procedures. Services provided from the Veterinary Core include development of veterinary support protocols specific to each experimental design, and consultation on the inclusion of imaging procedures into existing protocols to obtain Institutional Animal Care and Use Committee approval. To date, 75 investigators representing 13 programs have used facility instrumentation. 42% of the users are peer-review-funded investigators. Utilization continues to increase as the facility and its capabilities become better known to the local cancer research community. The capabilities of the facility continue to grow to meet experimental demands. Publications are evolving at a rapid pace, and although only a few are published, the acceptance rate has been nearly 100%. Funding for the SACIRF is currently CCSG (43%), user fees (36%), and MDACC (21%).

小动物癌症成像研究设施 (SACIRF) 为癌症研究人员提供最新的小动物体内实验成像技术和技术。该设施包括最先进的艺术仪器，包括磁共振模式（MR、Bruker4.7 T、40 cm Biospec）、 X 射线计算机断层扫描（来自增强视觉系统的微型 CT 和正在开发的体积 CT）与通用电气合作）、投影射线照相术（Faxitron）和核成像（M.Cam gamma）来自西门子的相机和来自 Concorde Microsystems 的微型 PET）。期间将添加光学成像该奖项的第一年（与生物医学工程合作开发的仪器德克萨斯大学奥斯汀分校）。该仪器代表 MDACC 投资超过 300 万美元。这 SACIRF 在动物支持设施中为仪器分配了空间，以方便纳入正在进行的癌症研究中的成像研究，以及专用的办公室和发育实验室空间支持设施运营。教职员工在每个模式领域都具有良好的资质，包括当前的图像采集和图像分析技术。专业领域包括定量组织表征 (MR)、微血管生理学成像（MR、核、CT 和光学）、扩散成像用于估计细胞密度 (MR)、代谢成像（核、正电子发射断层扫描 [PET]、光学和 MR 光谱）和血管成像（MR、CT 和 X 射线）。该设施的服务包括成像协议设计、定制定位系统、定制数据采集硬件和软件、图像分析、数据归档、提供硬拷贝和数字数据交付以及数据库维护。这 Veterinary Core 包括一个专门的支持团队，提供高效的成像研究和非常成像过程中动物死亡率低。兽医核心提供的服务包括针对每个实验设计制定兽医支持协议以及咨询关于将成像程序纳入现有协议以获得机构动物护理和使用委员会批准。迄今为止，代表 13 个项目的 75 名研究人员已使用设施仪器。 42% 的用户是同行评审资助的研究人员。随着设施及其设施的使用不断增加当地癌症研究界更加了解其能力。设施的能力继续发展以满足实验需求。出版物正在快速发展，尽管仅发表了几篇，接受率已接近100%。 SACIRF 的资金目前为 CCSG (43%)、用户费 (36%) 和 MDACC (21%)。