04 Small Animal Imaging Facility

04 小动物成像设备

• 批准号: 10655502
• 负责人: JOHN D. HAZLE
• 金额: $ 30.85万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-28 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10655502
• 关键词: Address; Advanced Malignant Neoplasm; Agreement; Anatomy; Animal Housing; Animals; Basic Science; Biochemical; Cancer Center; Cancer Center Support Grant; Capital; Complement; Computed Tomography Scanners; Consultations; Contracts; Data; Data Analyses; Dedications; Development; Devices; Disease Progression; Ensure; Equipment; Experimental Designs; Faculty; Funding; Grant; Housing; Image; Imaging technology; Income; Institution; Investments; Journals; Laboratories; Location; Magnetic Resonance; Magnetism; Maintenance; Metabolic; Methods; Mission; Nuclear; Peer Review; Positron-Emission Tomography; Preparation; Publications; Publishing; Radiation; Reporting; Research; Research Design; Research Personnel; Resources; Rodent; Roentgen Rays; Science; Services; Site; System; Technical Expertise; Technology; Tissue Harvesting; Training; animal imaging; anticancer research; biomedical imaging; data acquisition; design; experience; experimental study; imaging biomarker; imaging facilities; imaging study; imaging system; improved; insight; instrumentation; laboratory facility; magnetic field; member; metabolic imaging; minimally invasive; new technology; novel; operation; optical imaging; photoacoustic imaging; pre-clinical; preclinical imaging; programs; prototype; quantitative imaging; radiotracer; single photon emission computed tomography; tomography; treatment response; tumor; ultrasound

PROJECT SUMMARY: SMALL ANIMAL IMAGING FACILITY (SAIF) The mission of the Small Animal Imaging Facility (SAIF) is to advance cancer research by providing cancer center members with powerful imaging technologies and the expertise necessary to successfully integrate imaging sciences into preclinical cancer research. Dr. John D. Hazle serves as director, and Dr. James A. Bankson serves as co-director. The facility includes faculty experts, specially trained staff, and state-of-the-art imaging instrumentation, most of which is not available anywhere else in the cancer center. The SAIF has 3 separate sites across the campus to ensure convenient access to all cancer center members. SAIF imaging laboratories are located on the North Campus adjacent to and contiguous with the small animal vivarium, inside the South Campus Vivarium, and in South Campus Research Building #3. SAIF faculty and staff are available to support all aspects of imaging in preclinical cancer research, from proposal and experiment design through data acquisition, analysis, interpretation, and presentation. Currently, the SAIF has 21 unique pieces of imaging equipment optimized for small animals and a full complement of ancillary equipment for support of animals before, during, and after experiments. The imaging equipment includes 3 high-field magnetic resonance scanners, a low-field permanent magnet magnetic resonance scanner, a dynamic nuclear polarization system for generating hyperpolarized magnetic resonance agents, a microcomputed tomography system, a positron emission tomography/single-photon emission computed tomography/computed tomography scanner, 2 small- animal radiation research platforms, 2 ultrasound systems (1 capable of photoacoustic imaging), a dedicated photoacoustic imaging system, a cabinet X-Ray system, 6 optical imaging systems, and a prototype magnetic relaxometry system (on loan as part of a research agreement). During this grant period, MD Anderson has funded $5,918,344 in capital equipment, and approximately $1.1M has been obtained through NCI Shared or High-end Instrumentation grants. Annual operational funding is $195,521 (20%) from the CCSG, $719,742 (74%) from program income, and $53,413 (6%) of institutional support. During this 6-year grant period, the SAIF served a total of 250 cancer center members, including investigators from all 16 CCSG programs. A total of 87% of all usage was peer-review funded, and the SAIF is requesting $200,057 (20%) from the CCSG in grant Yr44. Overall use has increased 2.7-fold in Yr42 over the average use in the prior funding cycle. The SAIF supported 181 peer-reviewed publications during this reporting period, with 51 (28%) published in journals with IF >10 and 119 (66%) published in those with IF >5. The specific aims are: Aim 1: To maintain a broad range of state-of-the-art imaging instrumentation and dedicated staff that support the preclinical imaging needs of cancer center members; Aim 2: To provide consultation, training and support in the planning, acquisition, and analysis of imaging data; and Aim 3: To develop and implement new technologies and methods that improve the accuracy and precision of quantitative imaging biomarkers in preclinical cancer research.

项目摘要：小动物成像设施 (SAIF) 小动物成像设施 (SAIF) 的使命是通过提供癌症研究来推进癌症研究 中心成员拥有强大的成像技术和成功整合所需的专业知识 成像科学进入临床前癌症研究。 John D. Hazle 博士担任主任，James A. 班克森担任联合董事。该设施包括教师专家、经过专门培训的工作人员和最先进的设施 成像仪器，其中大部分在癌症中心的其他任何地方都没有。高金有 3 校园内有不同的站点，以确保所有癌症中心成员都能方便地到达。 SAIF成像 实验室位于北校区，毗邻小动物饲养场，内部 南校区动物园和南校区研究大楼#3。 SAIF教职员工随时待命 支持临床前癌症研究中成像的各个方面，从提案和实验设计到 数据采集​​、分析、解释和呈现。目前，高金拥有21件独具特色的影像作品 针对小动物优化的设备以及用于支持动物的全套辅助设备 实验前、实验中和实验后。成像设备包括3台高场磁共振 扫描仪、低场永磁磁共振扫描仪、动态核极化系统 用于产生超极化磁共振剂、微计算机断层扫描系统、正电子 发射断层扫描/单光子发射计算机断层扫描/计算机断层扫描扫描仪，2个小型 动物辐射研究平台、2个超声系统（1个能够进行光声成像）、专用 光声成像系统、一个柜式 X 射线系统、6 个光学成像系统和一个原型磁 松弛测量系统（作为研究协议的一部分借用）。在此资助期内，MD 安德森资助了 资本设备价值 5,918,344 美元，通过 NCI 共享或高端获得约 110 万美元 仪器补助金。年度运营资金为 CCSG 提供的 195,521 美元 (20%)，来自 CCSG 的 719,742 美元 (74%) 计划收入，以及 53,413 美元 (6%) 的机构支持。在这 6 年资助期内，SAIF 提供了 共有 250 名癌症中心成员，包括来自所有 16 个 CCSG 项目的研究人员。合计占全部的87% 使用是由同行评审资助的，SAIF 正在向 CCSG 申请第 44 年拨款 200,057 美元（20%）。全面的 42 年的使用量比上一个资助周期的平均使用量增加了 2.7 倍。高金支持 181 本报告期内发表的同行评审出版物，其中 51 篇 (28%) 发表在 IF >10 和 119 的期刊上 (66%) 发表在 IF >5 的文章中。具体目标是： 目标 1：保持广泛的最先进技术 支持癌症中心临床前成像需求的成像仪器和专职人员 会员；目标 2：在规划、获取和分析方面提供咨询、培训和支持 成像数据；目标 3：开发和实施提高准确性的新技术和方法 临床前癌症研究中定量成像生物标志物的精度和精度。