RR&D Research Career Scientist Award Application - Renewal of Margot Damaser SRCS Award

基本信息

批准号：
10686071
负责人：
MARGOT S. DAMASER
金额：
--
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2028-09-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686071
关键词：
Acceleration Activities of Daily Living Advisory Committees Affect Agreement American Animal Experiments Animal Model Animals Area Award Biomedical Engineering Birth trauma Bladder Book Chapters Books Breakthrough device Caring Catheters Central Nervous System Diseases Clinic Clinical Collaborations Conscious Constipation Development Device Designs Device or Instrument Development Devices Diabetes Mellitus Diagnosis Disease Elderly Electric Stimulation Engineering Evaluation Exercise Extravasation Fecal Incontinence Female Foundations Functional disorder Funding Goals Grant Grant Review Gymnastics Homing Human IACUC Impairment Interdisciplinary Study Intestines Investments Joints Journals Kidney Laboratory Research Legal patent Licensing Manuscripts Massachusetts Measures Medical Medical Device Medicine Mentors Methods Modeling Monitor Motivation Multiple Trauma Muscle Nanotechnology Natural regeneration Nerve Neurogenic Bladder Ohio Organ Paper Parachuting Pelvic Floor Disorders Pelvic floor structure Physical activity Physiology Positioning Attribute Prevalence Productivity Publishing Recovery Reference Standards Regenerative Medicine Rehabilitation therapy Research Research Personnel Research Project Grants Resistance Rodent Role Running Scientific Societies Scientist Services Source Spinal cord injury Stress Urinary Incontinence System Technology Testing Training Translating Translational Research Translations Traumatic Brain Injury United States Department of Veterans Affairs United States National Institutes of Health Universities Urethra Urinary Incontinence Urology Vagina Veterans Weight Weight Lifting Woman career clinical translation college diabetic human subject improved innovation member minimally invasive nerve injury neurotrophic factor novel overexpression pelvic organ prolapse peripheral nerve regeneration professor programs regenerative regenerative approach rehabilitation research research and development research in practice stem cells technology platform translational potential wireless

项目摘要

Summary/Abstract Dr. Margot Damaser is Senior Research Career Scientist in the RR&D Service of the US Department of Veterans Affairs and Professor of Biomedical Engineering in the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. She is Deputy Director and co-PI of the Advanced Platform Technology Center. Dr. Damaser's research is focused on using principles of engineering, physiology, and regenerative medicine to develop new models and devices for improvement of diagnosis, treatment, and rehabilitation of pelvic floor disorders (PFD): urinary incontinence, fecal incontinence, and pelvic organ prolapse. Rehabilitation of these autonomic organs is an understudied field with great relevance to Veterans, particularly women and those with spinal cord injury or neurogenic disorders. She has initiated development of novel wireless catheter- free technology for monitoring bladder and bowel function during conscious ambulation and activities of daily living. This innovative monitoring system provides a paradigm shift in diagnosis, rehabilitation, and treatment of urinary and fecal incontinence, constipation and voiding dysfunction. In addition, her research focuses on regenerative approaches to treat PFD, including stem cells and/or their secretions, electrical stimulation, and elastogenic nanotechnology. She has made significant advances in this area by demonstrating that treatment with the secretions from stem cells is highly regenerative even when the treatment is given systemically, suggesting minimal invasive therapy could be utilized. In addition, she has demonstrated that electrical stimulation can regenerate peripheral nerves even in situations of impaired regeneration. These treatments are promising to promote rehabilitation, particularly for Veterans with impaired regeneration, such as the elderly, diabetics, and those with polytrauma affecting both nerves and muscles. The over-arching goals of this research is to benefit Veterans. To that end Dr. Damaser has invested effort to translate technology and has 4 issued patents, 3 pending patents, and 1 provisional patent application, as well as 2 licensed technologies, 1 option to license a technology, 1 joint development agreement, and 1 evaluation agreement with multiple companies in the field. In 2019, Dr. Damaser was 1st Place winner for the UroMonitor in the Massachusetts Medical Device Development (M2D2) $200k Challenge, demonstrating the translational potential of her technology. She is thus on track to translate novel diagnosis, treatment and rehabilitation methods to the clinic within the next 10 years. She has obtained funding for her research from VA, NIH, DOD, the State of Ohio, and foundation and corporate sources. In recognition of the significance of her research, Dr. Damaser was elected to the American Institute for Medical and Biological Engineering (AIMBE) in 2014. During the current SRCS award period, Dr. Damaser published 37 research manuscripts, 19 review papers and 4 book chapters. She co-edited a book that has become a standard reference in the field and mentored many young investigators. Dr. Damaser is currently Deputy Director and co-PI of the Advanced Platform Technology Center (2 I50 RX001871), PI of an NIH R21 grant, (R21HD095234), PI of an NIH Other Transaction Award (NIH OT2 OD023873), and co- Investigator on multiple NIH and foundation grants. She served for 12 years as Chair of the local IACUC (2008- 2020) and serves as a member of the Field Advisory Committee to VA ORO in addition to serving on multiple VA and NIH grant review panels. In addition, she uses her research program to train many clinical, scientific, and engineering trainees in research practices, enlarging the impact of her research. In recognition of this effort, Dr. Damaser was awarded the Urology Care Foundation Distinguished Mentor Award in 2020. In her role as co-PI and Deputy Director of the APT Center, Dr. Damaser is in a position to expand her influence to mentor others in conducting productive translational rehabilitation research and development during the upcoming renewal period of her Senior Research Career Scientist Award.

摘要/摘要 Margot Damaser 博士是美国农业部 RR&D 服务部的高级研究职业科学家克利夫兰诊所勒纳医学院退伍军人事务部和生物医学工程教授凯斯西储大学。她是先进平台技术副总监兼联合PI 中心。 Damaser 博士的研究重点是利用工程学、生理学和再生原理医学开发新模型和设备以改善诊断、治疗和康复盆底疾病（PFD）：尿失禁、大便失禁和盆腔器官脱垂。康复治疗这些自主器官的功能是一个尚未充分研究的领域，与退伍军人特别是女性和退伍军人密切相关。患有脊髓损伤或神经源性疾病的人。她发起了新型无线导管的开发免费技术，用于在有意识的行走和日常活动期间监测膀胱和肠道功能活的。这种创新的监测系统为疾病的诊断、康复和治疗提供了范式转变。尿失禁和大便失禁、便秘和排尿功能障碍。此外，她的研究重点是治疗 PFD 的再生方法，包括干细胞和/或其分泌物、电刺激和弹性纳米技术。她通过证明治疗在这一领域取得了重大进展即使进行全身治疗，干细胞的分泌物也具有高度再生性，表明可以采用微创治疗。此外，她还证明了电即使在再生受损的情况下，刺激也可以使周围神经再生。这些治疗方法是承诺促进康复，特别是对于再生能力受损的退伍军人，例如老年人，糖尿病患者以及患有影响神经和肌肉的多发伤的患者。本研究的总体目标是为了让退伍军人受益。为此，Damaser 博士投入了精力转化技术，并发布了 4 专利、3 项正在申请的专利和 1 项临时专利申请，以及 2 项许可技术、1 项选择权与多家公司获得一项技术许可、1份联合开发协议和1份评估协议领域。 2019 年，Damaser 博士凭借 UroMonitor 在马萨诸塞州医学界获得第一名设备开发 (M2D2) 20 万美元挑战赛，展示了她的技术的转化潜力。因此，她有望将新的诊断、治疗和康复方法应用到临床中。未来10年。她的研究获得了 VA、NIH、DOD、俄亥俄州和基金会的资助和企业来源。为了表彰她研究的重要性，Damaser 博士被选为 2014 年美国医学与生物工程研究所 (AIMBE)。本届 SRCS 获奖期间期间，Damaser 博士发表了 37 篇研究手稿、19 篇评论论文和 4 个书籍章节。她共同编辑这本书已成为该领域的标准参考书，并指导了许多年轻的研究人员。达马瑟博士现任先进平台技术中心（2 I50 RX001871）副主任、联席PI， NIH R21 拨款（R21HD095234），NIH 其他交易奖的 PI（NIH OT2 OD023873），以及共同多项 NIH 和基金会资助的研究员。她担任当地 IACUC 主席长达 12 年（2008 年- 2020），除在多个机构任职外，还担任 VA ORO 现场咨询委员会成员 VA 和 NIH 拨款审查小组。此外，她利用她的研究项目培训了许多临床、科学、和工程实习生的研究实践，扩大了她的研究的影响。为了表彰这一努力， Damaser 博士于 2020 年荣获泌尿科护理基金会杰出导师奖。作为 APT 中心的联合 PI 和副主任，Damaser 博士能够扩大她的影响力来指导其他人在即将到来的期间进行富有成效的转化康复研究和开发她的高级研究职业科学家奖的续期。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review.

盆腔器官脱垂的小鼠敲除模型：系统评价。

DOI：
发表时间：
2022-07
期刊：
影响因子：
1.8
作者：
Allen;Bortolini, Maria A T;Damaser, Margot S
通讯作者：
Damaser, Margot S

Feasibility of Real-Time Conditional Sacral Neuromodulation Using Wireless Bladder Pressure Sensor.

使用无线膀胱压力传感器进行实时条件骶神经调节的可行性。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Majerus, Steve J A;Offutt, Sarah J;Brink, Thaddeus S;Vasoli, Vincent;Mcadams, Ian;Damaser, Margot S;Zirpel, Lance
通讯作者：
Zirpel, Lance

Stromal cell derived factor 1 plasmid to regenerate the anal sphincters.

基质细胞衍生的因子 1 质粒可再生肛门括约肌。