Small Animal Imaging

小动物成像

• 批准号: 7714127
• 负责人: THEODORE G KRONTIRIS
• 金额: $ 4.97万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714127
• 关键词: Anatomy; Animals; Arts; Biodistribution; Bioluminescence; Biomedical Research; Budgets; Cancer Center; Cancer Center Support Grant; Cell physiology; Cities; Clinical; Consult; Extramural Activities; Funding; Gamma Cameras; Gamma counter; Human Resources; Image; Imaging Techniques; Institution; Invasive; Laboratories; Malignant Neoplasms; Medical Research; Mission; Molecular; Monitor; Numbers; Operative Surgical Procedures; PET/CT scan; Peer Review; Positron-Emission Tomography; Process; Reporting; Research; Research Personnel; Resource Sharing; Small Animal Imaging Systems; System; Techniques; Technology; Translational Research; Work; animal resource; anticancer research; base; cost; experience; in vivo; member; optical imaging; pre-clinical research; programs

Molecular-based imaging provides new opportunities to assess vital cellular processes in vivo. The ability to monitor the molecular processes of cancer via non-invasive imaging may provide critical information regarding the effects of therapy. In the context of pre-clinical research, the use of in vivo imaging permits the acquisition of a complete dynamic biodistribution study in each animal, thereby reducing the number of animals required to reach a statistically adequate result; often the techniques used in small animal imaging are directly transferable to the clinical setting. The Small Animal Imaging Core (SAIC) is a new shared resource dedicated to providing investigators access to the state-of-the-art in small animal imaging capabilities for use in basic and translational research relevant to the mission of the City of Hope Cancer Center. Specific aims of the SAIC include: (1) maintaining a thorough understanding of the current capabilities and limitations of small animal imaging as they pertain to cancer research; (2) implementing, developing, calibrating, maintaining, and operating relevant imaging systems within the context of a small animal imaging laboratory; and (3) optimizing the use of small animal imaging in research at City of Hope by consulting with investigators. Core personnel currently include a Director, an imaging physicist, and a manager, all of whom are highly experienced in the use of imaging for research with animals. Small animal imaging systems in operation include two units for bioluminescence optical imaging (I VIS 100, Xenogen Corp.); a gamma camera (Y IMAGER, Biospace, Inc.); a PET scanner (microPET R4, CTIMI, Inc.); and a CT scanner (microCAT II Hi Res, CTIMI, Inc.). The microPET and microCAT are readily used in tandem to generate co-registered functional-anatomic PET/CT images. The Animal Resources Center has provided four rooms within the Parvin Biomedical Research Building for use by the animal imaging program (one room for the microPET, microCAT, and the y-IMAGER; two rooms for the Xenogen MS machines; and one room for a gamma counter). A system has been developed for billing users for a portion of the costs of the imaging procedures. During the first 12-month reporting period, the SAIC was used by 13 Cancer Center members from 3 Research Programs and peer-reviewed usage represented 89% of total usage. Annual budget for the core is $165,922 (97% institution, 3% chargebacks); 42% ($70,000) is being requested from the CCSG.

基于分子的成像为评估体内重要细胞过程提供了新的机会。有能力 通过非侵入性成像监测癌症的分子过程可以提供关键信息 关于治疗的效果。在临床前研究的背景下，体内成像的使用允许 获得每只动物的完整动态生物分布研究，从而减少 需要达到统计学上足够的结果的动物；通常用于小动物成像的技术 可以直接转移到临床环境。小动物成像核心 (SAIC) 是一个新的共享 致力于为研究人员提供最先进的小动物成像资源 用于与希望之城癌症使命相关的基础和转化研究的能力 中心。国家工商总局的具体目标包括： (1) 全面了解当前的情况 小动物成像与癌症研究相关的能力和局限性； (2) 实施、 在小型环境中开发、校准、维护和操作相关成像系统 动物成像实验室； (3) 在希望之城的研究中优化小动物成像的使用 与调查人员协商。目前核心人员包括一名主任、一名成像物理学家和一名 经理，他们在使用成像进行动物研究方面都具有丰富的经验。小动物 运行中的成像系统包括两个用于生物发光光学成像的装置（I VIS 100、Xenogen 公司）；伽玛相机（Y IMAGER，Biospace，Inc.）； PET 扫描仪（microPET R4，CTIMI，Inc.）；和CT 扫描仪（microCAT II Hi Res，CTIMI，Inc.）。 microPET 和 microCAT 很容易串联使用 生成联合配准的功能解剖 PET/CT 图像。动物资源中心提供 帕尔文生物医学研究大楼内有四个房间供动物成像项目使用（一间房间 适用于 microPET、microCAT 和 y-IMAGER；两个用于放置 Xenogen MS 机器的房间；和一间房间 用于伽玛计数器）。已经开发了一个系统，用于向用户收取部分成像费用 程序。在前 12 个月的报告期内，13 名癌症中心成员使用了 SAIC 来自 3 个研究项目，同行评审的使用量占总使用量的 89%。年度预算为 核心费用为 165,922 美元（97% 为机构费用，3% 为退款）；向 CCSG 请求 42%（70,000 美元）。