Intervention Development and Pilot Study to Prevent Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders

预防未经治疗的夏威夷原住民和太平洋岛民阿片类药物使用障碍的干预措施开发和试点研究

• 批准号: 10057426
• 负责人: Andrew Makoto Subica
• 金额: $ 24.94万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10057426
• 关键词: AIDS/HIV problem; Address; Adult; Affect; Alaska Native; Alcohol or Other Drugs use; American Indians; Asian Americans; Back; Clinic; Clinical; Communities; Consensus; Data; Data Analytics; Data Collection; Decision Making; Economics; Educational Status; Elderly; Evidence based intervention; Evidence based practice; Family Sizes; Family member; Feasibility Studies; Feedback; Focus Groups; Foundations; Future; General Population; Goals; Hawaii; Health Personnel; Immigrant; Indigenous; Intervention; Island; Journals; Link; Literature; Manuscripts; Measurement; Measures; Mental Health; Methodology; Methods; Modeling; National Institute of Drug Abuse; Native Hawaiian; Opioid; Overdose; Pacific Island Americans; Pamphlets; Paper; Participant; Peer Review; Physicians; Pilot Projects; Population; Preparation; Process; Provider; Psyche structure; Public Health; Publishing; Race; Randomized; Randomized Controlled Trials; Research; Review Literature; Risk; Rural; Subgroup; Substance Use Disorder; Testing; Treatment Efficacy; United States National Institutes of Health; Utah; Waiting Lists; Work; barrier to care; base; behavioral health; constructivism; cost; cost effective; design; disorder risk; efficacy testing; efficacy trial; evidence base; experience; follow-up; health disparity; high risk; improved; innovation; intervention effect; non-opioid analgesic; novel; opioid epidemic; opioid use disorder; overdose death; peer; prevent; social; systematic review; technical report; theories; therapy design; therapy development; treatment services

Abstract Pacific Islanders are an indigenous/colonized U.S. racial group that carries very high risk for opioid use disorders (OUD) due to their many social, economic, and health disparities and heavy burden of mental health and substance use disorders. Unfortunately, Pacific Islanders rarely seek OUD treatment for reasons that remain unexplored and unknown, resulting in high levels of unmet treatment need that increases Pacific Islanders’ likelihood for experiencing opioid-related harms such as overdose and death. Despite their urgent need for OUD treatment, Pacific Islanders remain absent from current opioid research and do not seek formal treatment services during this severe public health crisis. The proposed R34 study will address this research and clinical gap by applying multifaceted methods to develop and pilot test the first intervention components designed to prevent untreated OUDs by increasing Pacific Islander OUD treatment seeking. Drawing from this team’s earlier behavioral health research with Pacific Islanders, we will use a culturally tailored intervention development approach that includes constructivist grounded theory, focus groups, and a deliberative public decision-making process called citizens’ panels to engage lay Pacific Islanders in culturally grounding existing evidence-based practices to increase Pacific Islander OUD treatment seeking. By combining this collected information with feedback from a council of Pacific Islander experts and a Cochrane-style systematic review of the literature on OUD, substance use, and mental health treatment- seeking interventions, we will create a conceptual model containing culturally grounded components for the first OUD treatment-seeking intervention for Pacific Islanders. Simultaneously, we will create a set of questions to measure the effects of these intervention components. The intervention components and our measurement questions will then be pilot tested with a small group of lay Pacific Islander adults for feasibility, acceptability, and perceived efficacy in preparation for a future efficacy trial. Research findings will be disseminated back to our participants and target communities, community partners (organizations and clinics), and the scientific community via brochures, technical reports, community forums, and academic presentations and papers.

抽象的 太平洋岛民是美国土著/殖民地种族群体，使用阿片类药物的风险非常高 由于许多社会、经济和健康差异以及沉重的心理健康负担而导致的精神障碍（OUD） 不幸的是，太平洋岛民很少寻求 OUD 治疗，原因如下： 仍未被探索和未知，导致太平洋地区未满足的治疗需求增加 尽管情况紧急，但岛民遭受阿片类药物相关伤害（例如服用过量和死亡）的可能性。 由于需要 OUD 治疗，太平洋岛民仍然缺席当前的阿片类药物研究，并且不寻求正式的 在这场严重的公共卫生危机期间提供治疗服务。 拟议的 R34 研究将通过应用多方面的方法来解决这一研究和临床差距 开发并试点测试第一个干预措施，旨在通过增加 太平洋岛民 OUD 治疗寻求借鉴该团队早期的行为健康研究。 太平洋岛民，我们将使用根据文化量身定制的干预发展方法，其中包括 建构主义扎根理论、焦点小组以及称为公民决策的审议性公共决策过程 小组将让太平洋岛民在文化上扎根现有的循证实践，以提高 太平洋岛民寻求 OUD 治疗。 通过将收集到的信息与太平洋岛民专家委员会和 对 OUD、药物滥用和心理健康治疗文献的 Cochrane 式系统回顾 寻求干预措施，我们将创建一个概念模型，其中包含基于文化的组成部分 同时，我们将提出一系列针对太平洋岛民的 OUD 寻求治疗干预。 衡量这些干预措施的效果。 然后，将由一小群非专业太平洋岛民成年人对问题进行试点测试，以验证其可行性、可接受性、 以及为未来功效试验做准备的感知功效 研究结果将被传播回 我们的参与者和目标社区、社区合作伙伴（组织和诊所）以及科学界 通过小册子、技术报告、社区论坛以及学术演讲和论文与社区进行交流。