Intervention Development and Pilot Study to Prevent Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders

预防未经治疗的夏威夷原住民和太平洋岛民阿片类药物使用障碍的干预措施开发和试点研究

• 批准号: 10213686
• 负责人: Andrew Makoto Subica
• 金额: $ 24.19万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213686
• 关键词: AIDS/HIV problem; Address; Adult; Affect; Alaska Native; American Indians; Asian Americans; Back; Clinic; Clinical; Communities; Consensus; Data; Data Analytics; Data Collection; Decision Making; Economics; Educational Status; Elderly; Evidence based intervention; Evidence based practice; Family Sizes; Family member; Feasibility Studies; Feedback; Focus Groups; Foundations; Future; General Population; Goals; Hawaii; Health Personnel; Helping to End Addiction Long-term; Immigrant; Indigenous; Intervention; Island; Journals; Link; Literature; Manuscripts; Measurement; Measures; Mental Health; Methodology; Methods; Modeling; National Institute of Drug Abuse; Native Hawaiian; Opioid; Overdose; Pacific Island Americans; Pamphlets; Paper; Participant; Peer Review; Physicians; Pilot Projects; Preparation; Process; Provider; Psyche structure; Public Health; Publishing; Race; Randomized; Randomized Controlled Trials; Research; Review Literature; Risk; Rural; Subgroup; Substance Use Disorder; Testing; Treatment Efficacy; United States National Institutes of Health; Utah; Waiting Lists; Work; acceptability and feasibility; barrier to care; base; behavioral health; constructivism; cost; cost effective; design; disorder risk; economic disparity; efficacy testing; efficacy trial; evidence base; experience; feasibility testing; follow-up; health disparity; high risk; improved; innovation; intervention effect; non-opioid analgesic; novel; opioid epidemic; opioid use disorder; overdose death; peer; prevent; racial population; social disparities; substance use; systematic review; technical report; theories; therapy design; therapy development; treatment services

Abstract Pacific Islanders are an indigenous/colonized U.S. racial group that carries very high risk for opioid use disorders (OUD) due to their many social, economic, and health disparities and heavy burden of mental health and substance use disorders. Unfortunately, Pacific Islanders rarely seek OUD treatment for reasons that remain unexplored and unknown, resulting in high levels of unmet treatment need that increases Pacific Islanders’ likelihood for experiencing opioid-related harms such as overdose and death. Despite their urgent need for OUD treatment, Pacific Islanders remain absent from current opioid research and do not seek formal treatment services during this severe public health crisis. The proposed R34 study will address this research and clinical gap by applying multifaceted methods to develop and pilot test the first intervention components designed to prevent untreated OUDs by increasing Pacific Islander OUD treatment seeking. Drawing from this team’s earlier behavioral health research with Pacific Islanders, we will use a culturally tailored intervention development approach that includes constructivist grounded theory, focus groups, and a deliberative public decision-making process called citizens’ panels to engage lay Pacific Islanders in culturally grounding existing evidence-based practices to increase Pacific Islander OUD treatment seeking. By combining this collected information with feedback from a council of Pacific Islander experts and a Cochrane-style systematic review of the literature on OUD, substance use, and mental health treatment- seeking interventions, we will create a conceptual model containing culturally grounded components for the first OUD treatment-seeking intervention for Pacific Islanders. Simultaneously, we will create a set of questions to measure the effects of these intervention components. The intervention components and our measurement questions will then be pilot tested with a small group of lay Pacific Islander adults for feasibility, acceptability, and perceived efficacy in preparation for a future efficacy trial. Research findings will be disseminated back to our participants and target communities, community partners (organizations and clinics), and the scientific community via brochures, technical reports, community forums, and academic presentations and papers.

抽象的 太平洋岛民是一个个人/殖民的美国种族群体，具有非常高的阿片类药物使用风险 由于其许多社会，经济和健康差异以及心理健康的繁重燃烧，疾病（OUD） 和药物使用障碍。不幸的是，太平洋岛民很少出于 保持未开发和未知，导致高水平的未满足治疗需求增加太平洋 岛民经历阿片类药物相关的危害（例如过量和死亡）的可能性。尽管他们紧急 需要OUD治疗，太平洋岛民仍缺乏当前的阿片类药物研究，不寻求正式 在这场严重的公共卫生危机期间的治疗服务。 拟议的R34研究将通过将多方面方法应用于 开发和试点测试第一个旨在通过增加未经处理的OUD的干预组件 太平洋岛民奥德治疗寻求。从该团队早期的行为健康研究中汲取 太平洋岛民，我们将使用一种文化量身定制的干预开发方法，其中包括 建构主义扎根的理论，焦点小组和一个审议的公共决策过程称为公民 与外行太平洋岛民参与文化基础的循证实践以增加的小组讨论 太平洋岛民奥德治疗寻求。 通过将这些收集的信息与太平洋岛民专家理事会的反馈相结合， Cochrane风格的系统综述有关OUD，药物使用和心理健康治疗的文献 - 寻求干预措施，我们将创建一个概念模型，其中包含文化基础的组成部分 太平洋岛民的首次OUD寻求治疗干预。同时，我们将创建一组问题 测量这些干预组件的影响。干预组件和我们的测量 然后，将与一小群太平洋岛民成年人进行试验，以实现可接受性，可接受性， 以及为未来效率试验做准备的效率。研究发现将被传播回 我们的参与者和目标社区，社区合作伙伴（组织和诊所）以及科学 通过小册子，技术报告，社区论坛以及学术演讲和论文进行社区。