Hemoglobin Switching Meeting

血红蛋白转换会议

基本信息

批准号：
10064453
负责人：
LEONARD Ira ZON
金额：
$ 1万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10064453
关键词：
American Society of Hematology Anabolism Back Biochemical Biochemistry Carbon Dioxide Cell Differentiation process Cells Cellular biology Clinical Collaborations Complementary DNA Crete Development Developmental Biology Disease Epigenetic Process Erythrocytes Erythropoietin Etiology Europe Faculty Family Fertilization Gene Expression Regulation Genes Genetic Genetic Diseases Genomics Globin Greece Hematology Hematopoietic Hemoglobin Hemoglobinopathies Hereditary Disease Human Cloning Human Genetics Inherited International Lung Metabolic Diseases Metabolism Minority Molecular Molecular Biology Mutation Oxygen Participant Physiology Postdoctoral Fellow Process Research Research Personnel Science Scientist Sickle Cell Anemia Site Structure Students Therapeutic Clinical Trial Tissues Woman Work beta Thalassemia career disease phenotype drug development effective therapy gene therapy genomic locus man meetings novel phenomenological models stem cells success symposium therapy development transcription factor

项目摘要

Abstract The biennial Hemoglobin Switching Conferences have been ongoing for 43 years, and there are multiple reasons for its resounding, continued success. First and foremost, the organizers Higgs, Engel, Zon and Sankaran strive to identify and then highlight new discoveries by always including new, young investigators and studies that impinge on the process of globin biosynthesis. Second, this is the only venue (other than the annual ASH meeting, with more than 25,000 participants) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, the hemoglobinopathies, the most common inherited diseases in man. Third, the meetings have historically evolved with intense focus on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin and the discovery of the GATA and KLF transcription factor families, but it has also launched the careers of many of the current leaders in this field (indeed, numerous former postdoctoral fellows and current faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the biennial alternation in conference site between the U.S. and Europe. In 2020 the Conference will be held in Crete, Greece.

抽象的两年一的血红蛋白转换会议已经进行了43年，并且有多个其响亮，持续成功的原因。首先，组织者Higgs，Engel，Zon和桑卡兰（Sankaran）努力识别，然后通过包括新的，年轻的调查员来突出发现新发现以及影响球蛋白生物合成过程的研究。第二，这是唯一的场所（除了年度灰分会议，有25,000多名参与者）将基础科学家和临床医生汇集在一起讨论血红蛋白病的分子和发育起源和治疗人类中最常见的遗传疾病。第三，这次会议历史上已经进化，重点是无论科学何处，都保持着极其局部的态度，并且不仅是展示的论坛第一个cDNA克隆，第一个克隆的人类基因组基因座（以及第一个突变），促红细胞生成素以及GATA和KLF转录因子家庭的发现，但也推出了该领域许多现任领导人的职业（实际上，许多以前的博士后研究员和当前教师在本次会议上首先在全体会议上介绍了他们的工作）。第四，这是唯一的会议从美国内部和境外调查人员通常，通常会有通常平等的话题这一事实反映了美国和欧洲之间的会议地点两年期的交替。 2020年会议将在希腊克里特岛举行。