Evaluating Cumulative Environmental Exposure to Metals and Non-metals and Community-level Health Using Geospatial Modeling and Personal Exposure Assessment

使用地理空间建​​模和个人暴露评估评估金属和非金属的累积环境暴露以及社区层面的健康

• 批准号: 10062403
• 负责人: Joseph Hamilton Hoover
• 金额: $ 33.05万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10062403
• 关键词: Address; Air; Animals; Area; Autoimmunity; Biological Monitoring; Cardiovascular Diseases; Chemical Exposure; Chemicals; Chronic Disease; Collaborations; Communities; Complex; Data; Decision Analysis; Development; Diet; Disease; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Exposure to; Gases; Goals; Health; Health Status; Health Surveys; Human; Immune; Immune response; Immunologic Markers; Immunologics; Immunology; Individual; Information Dissemination; Infrastructure; Ingestion; Inhalation; Investigation; Knowledge; Lead; Livestock; Malignant Neoplasms; Measurement; Metal exposure; Metals; Modeling; Movement; Native Americans; Navajo; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Pesticides; Pilot Projects; Plant Oils; Plants; Policy Maker; Population; Power Plants; Process; Production; Reporting; Research; Research Project Grants; Reservations; Resources; Risk; Rivers; Sampling; Silicones; Sioux Indians; Site; Soil; Source; Statistical Methods; Statistical Models; Testing; Uncertainty; Uranium; Water; Work; base; chemical release; cold temperature; contaminated water; experience; exposed human population; exposure pathway; exposure route; health disparity; health equity; improved; innovation; land use; member; novel; predictive modeling; response; tribal community; tribal health; tribal lands; wasting

Project Summary Communities that practice traditional land-based cultures are intimately connected to the environment due to cultural, spiritual, and traditional practices. While our Center’s previous work demonstrated varying degrees of metal exposure among members of Navajo Nation, Cheyenne River Sioux (CRST) and Apsaálooke (Crow), single exposure pathway (e.g. water) investigations were not sufficient to explain individual-level exposure and adverse health outcomes. Moreover, there remains limited knowledge on other chemical exposure sources prominent on Tribal lands, such as trash burning, that may lead to accumulation of microplastics, volatile, and semi-volatile compounds in the environment and lead human exposures. This research project will address the challenge of integrating multiple exposure routes for Native communities through modeling combined environmental exposure potential. We will adapt an existing GIS-based multi-criteria decision analysis approach that can integrate air, water, and soil pathways previously used by our group. Our modeling framework enables integration of novel soil, water, air, and plant data on microplastics and other chemicals produced by low-temperature trashing combustion. This research approach is innovative because it investigates combined exposures on tribal lands, including microplastics and combusted plastic by-products against a background of high metal exposures. We will (1) develop predictive and validate combined environmental exposure models based on GIS-based multi-criteria decision analysis, which considers chemical sources, topography, infrastructure, and land-use practices; (2) ground truth model predictions through measurement of combined exposures for people and cultural resources (such as livestock and plants) using silicone wristbands, human biomonitoring, and immunology studies; and (3) collect community-scale health survey data to begin assessing exposure :disease relationships (e.g., cancer, autoimmunity, and cardiovascular disease) in collaboration with RP3. SA1 will generate the first combined environmental exposure spatial products for Apsaálooke (Crow) and Crow and CRST reservation lands and a refined product for NN. These spatial products will support environmental health research among Tribal communities and provide policy-makers with critical information to address Tribal health disparities. The studies proposed in SA2 provide important ground truthing of the GIS-based model through individual-level chemical and immune marker measurements. This will inform policy makers about the scope and extent of combined environmental exposures in their communities and allow us to consider the contributions of combined chemical exposures to associations with metals that we have observed in participant samples from these communities. The health survey data will provide data to validate and substantiate health disparities at individual community scale for tribal community partners, and at a scale consistent with the combined exposure prediction scale in our model.

项目摘要 从事传统土地文化的社区与环境密切相关 文化，精神和传统实践。虽然我们中心以前的工作表现出不同程度的不同 纳瓦霍国家（Navajo Nation），夏安河苏（Crst）（CRST）和apsaálooke（Crow）成员之间的金属暴露 单次暴露途径（例如水）的调查不足以解释个人级别的暴露和 不利的健康结果。此外，关于其他化学暴露源的知识仍然有限 在诸如垃圾燃烧之类的部落土地上，可能导致微塑料，挥发性和 环境中的半挥发性化合物并引导人类暴露。该研究项目将解决 通过建模组合为土著社区整合多个曝光路线的挑战 环境暴露潜力。我们将调整现有的基于GIS的多标准决策分析 可以整合我们组以前使用的空气，水和土壤通路的方法。我们的建模 框架使新的土壤，水，空气和植物数据都可以集成有关微塑料和其他化学物质的数据 由低温垃圾混合物产生。这种研究方法具有创新性，因为它 研究了在部落土地上的曝光，包括微塑料和燃烧的塑料副产品 在高金属暴露的背景下。我们将（1）发展预测和验证合并 基于基于GIS的多标准决策分析的环境暴露模型，该模型考虑化学 来源，地形，基础设施和土地利用实践； （2）通过地面真理模型通过 使用使用的人和文化资源（例如牲畜和植物）的合并暴露的测量 硅腕带，人类生物监测和免疫学研究； （3）收集社区规模的健康 开始评估暴露的调查数据：疾病关系（例如癌症，自身免疫性和 心血管疾病）与RP3合作。 SA1将产生第一个组合环境 Apsaálooke（乌鸦）以及乌鸦和CRST预订土地以及精制产品的曝光空间产品 对于nn。这些空间产品将支持部落社区之间的环境健康研究 向决策者提供关键信息，以解决部落健康差异。 SA2中提出的研究 通过个体级化学和免疫提供基于GIS的模型的重要基础真理 标记测量。这将为决策者提供有关联合环境的范围和范围 在其社区中接触，允许我们考虑化学曝光合并的贡献 我们与这些社区的参与者样本中观察到的金属的关联。健康 调查数据将提供数据以验证和证实各个社区规模的健康分配 部落社区合作伙伴，并且按照我们模型中的合并暴露预测量表一致。