Center for Native American Environmental Health Equity Research

美洲原住民环境健康公平研究中心

基本信息

批准号：
10372180
负责人：
Joseph Hamilton Hoover
金额：
$ 135.88万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10372180
关键词：
Affect Air Animals Arsenic Arts Autoimmunity Biological Cells Chemicals Cheyenne Chronic Disease Communication Communities Community Participation Complex Consultations Consumption Crows Custom Data Collection Diet Disease Environment Environmental Health Exposure to Food Food Chain Genetic Genetic Research Geography Goals Health Heating Home Human Immune System Diseases Indigenous Individual Industrialization Industry Infrastructure Ingestion Inhalation Intervention Language Life Style Link Livestock Malignant Neoplasms Manganese Metal exposure Metals Mining Modeling Modification Monitor Native Americans Natural Resources Navajo Outcome Pathway interactions Pattern Persons Phase Plants Plastics Policies Population Prevalence Prevention strategy Probability Process Recording of previous events Refuse Disposal Research Research Design Resources Risk Rivers Route Rural Community Science Services Sioux Indians Site Solid Solid Waste Disposals Source Stream Surveys Time Tribes Uncertainty United States Uranium Waste Management Water Weather Work cancer health disparity cancer risk cold temperature cooking design disease disparity disorder prevention distrust drinking water environmental health disparity experience exposed human population health disparity health equity immune function indigenous community meetings member mentoring community migration mobile sensor predictive modeling risk mitigation toxicant tribal community tribal member volatile organic compound wasting

项目摘要

SUMMARY: OVERALL - Center for Native Environmental Health Research Equity Nearly half of the Native American population of the United States lives in 13 western states in proximity of an estimated 161,000 abandoned hardrock mines, with more than 4,000 being abandoned uranium mines. Because of their reliance on natural resources to maintain traditional diets, lifestyles, customs and languages, these tribal communities have direct and frequent contact with metal mixtures from abandoned mine sites, creating exposures through multiple pathways including inhalation, drinking water, and ingestion of foods either directly or indirectly contaminated by migration of the wastes. Exacerbating these exposures are disparities in infrastructure, including services like safe drinking water and solid waste management. Lack of effective solid- waste management resulted historically in burning and open dumping of solid waste, but with the ever- increasing amounts of plastic entering the waste stream, the low-temperature, incomplete combustion of this process, and the environmental degradation through weathering, our tribal partners are increasingly concerned about the emissions of toxic degradation products of plastics into their environment. The concerns over how the combined toxicants from these processes and the metals we have already linked to immune dysfunction in these communities have led to this Phase 2 Native EH Equity proposal. We have found metals mixtures result in different exposure profiles across our three partnering indigenous communities: Navajo, Apsáalooke, and Cheyenne River Sioux. And while we see commonalities in immune dysfunction across these communities that can contribute to disparities in cancer and other chronic diseases, the metals exposures alone do not account for all of the risk. Therefore, in this Phase 2 Center we will develop an understanding of the emerging additional plastic degradation contaminant profiles, evaluating constituents and distribution of microplastics and other degradation products, along with emissions from extractive industries that could add to these classes of chemicals, in both stationary and mobile exposure assessments. We will monitor grazing patterns of livestock and their resulting exposures through air and consumption of plants and water, as well as stationary in-home and mobile monitoring on people during their normal activities to evaluate exposure components and pathways contributing the greatest risk with the ultimate goal of developing mitigation strategies at individual and tribal levels to inform decisions and policies to reduce the risks linked to increasing cancer and other chronic disease disparities in these communities. The resulting fine-scale predictive models, ground-truthed through monitoring, and the integration of multiple exposure streams will provide a resource to not only inform policy, but aid clinicians in identifying early risks to develop prevention strategies as well.

摘要：总体 - 土著环境健康研究中心美国近一半的美国原住民居住在西方13个州估计有161,000个废弃的硬石矿，有4,000多个被废弃的铀矿。由于他们对自然资源的缓解，以维持传统饮食，生活方式，习俗和语言，所以这些部落社区有直接并经常与废弃矿场的金属混合物接触，通过多种途径进行暴露，包括吸入，饮用水和摄入食物加剧这些暴露是差异基础设施，包括安全饮用水和固体废物管理等服务。缺乏有效的固体废物管理历史上导致燃烧和开放的固体废物倾销越来越多的塑料进入废物流，低温，不完整的组合过程，以及通过风化的环境退化，我们的部落伙伴越来越关注关于塑料的有毒降解产物的排放到其环境中。人们对如何这些过程中的毒物和我们已经与免疫功能障碍相关的金属这些社区导致了这一第2阶段的本地EH权益提案。我们发现金属混合物结果在我们三个合作伙伴的土著社区的不同曝光概况中：纳瓦霍人，阿普萨洛克和夏安河苏。虽然我们看到这些社区免疫功能障碍的共同点这可能导致癌症和其他慢性疾病的差异，仅金属暴露就不会考虑所有风险。因此，在这个阶段2中心，我们将对新兴的理解发展其他塑料降解污染物概况，评估成分和微塑料的分布和分布其他降级产品，以及提取行业的排放，可以增加这些类别固定和移动暴露评估中的化学药品。我们将监视牲畜的光栅模式以及它们通过空气和消费植物和水以及固定的内部暴露在正常活动中对人进行移动监控，以评估曝光组件和途径以最终目标的最终目的为个人和部落制定缓解策略的最终目标为了减少与癌症增加和其他慢性疾病有关的风险的决定和政策的水平这些社区的差异。由此产生的细尺度预测模型，通过监视以及多个曝光流的集成将提供资源，不仅为政策提供信息但是，援助临床医生也确定了制定预防策略的早期风险。