Center for Native American Environmental Health Equity Research

美洲原住民环境健康公平研究中心

基本信息

批准号：
10372180
负责人：
Joseph Hamilton Hoover
金额：
$ 135.88万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10372180
关键词：
Affect Air Animals Arsenic Arts Autoimmunity Biological Cells Chemicals Cheyenne Chronic Disease Communication Communities Community Participation Complex Consultations Consumption Crows Custom Data Collection Diet Disease Environment Environmental Health Exposure to Food Food Chain Genetic Genetic Research Geography Goals Health Heating Home Human Immune System Diseases Indigenous Individual Industrialization Industry Infrastructure Ingestion Inhalation Intervention Language Life Style Link Livestock Malignant Neoplasms Manganese Metal exposure Metals Mining Modeling Modification Monitor Native Americans Natural Resources Navajo Outcome Pathway interactions Pattern Persons Phase Plants Plastics Policies Population Prevalence Prevention strategy Probability Process Recording of previous events Refuse Disposal Research Research Design Resources Risk Rivers Route Rural Community Science Services Sioux Indians Site Solid Solid Waste Disposals Source Stream Surveys Time Tribes Uncertainty United States Uranium Waste Management Water Weather Work cancer health disparity cancer risk cold temperature cooking design disease disparity disorder prevention distrust drinking water environmental health disparity experience exposed human population health disparity health equity immune function indigenous community meetings member mentoring community migration mobile sensor predictive modeling risk mitigation toxicant tribal community tribal member volatile organic compound wasting

项目摘要

SUMMARY: OVERALL - Center for Native Environmental Health Research Equity Nearly half of the Native American population of the United States lives in 13 western states in proximity of an estimated 161,000 abandoned hardrock mines, with more than 4,000 being abandoned uranium mines. Because of their reliance on natural resources to maintain traditional diets, lifestyles, customs and languages, these tribal communities have direct and frequent contact with metal mixtures from abandoned mine sites, creating exposures through multiple pathways including inhalation, drinking water, and ingestion of foods either directly or indirectly contaminated by migration of the wastes. Exacerbating these exposures are disparities in infrastructure, including services like safe drinking water and solid waste management. Lack of effective solid- waste management resulted historically in burning and open dumping of solid waste, but with the ever- increasing amounts of plastic entering the waste stream, the low-temperature, incomplete combustion of this process, and the environmental degradation through weathering, our tribal partners are increasingly concerned about the emissions of toxic degradation products of plastics into their environment. The concerns over how the combined toxicants from these processes and the metals we have already linked to immune dysfunction in these communities have led to this Phase 2 Native EH Equity proposal. We have found metals mixtures result in different exposure profiles across our three partnering indigenous communities: Navajo, Apsáalooke, and Cheyenne River Sioux. And while we see commonalities in immune dysfunction across these communities that can contribute to disparities in cancer and other chronic diseases, the metals exposures alone do not account for all of the risk. Therefore, in this Phase 2 Center we will develop an understanding of the emerging additional plastic degradation contaminant profiles, evaluating constituents and distribution of microplastics and other degradation products, along with emissions from extractive industries that could add to these classes of chemicals, in both stationary and mobile exposure assessments. We will monitor grazing patterns of livestock and their resulting exposures through air and consumption of plants and water, as well as stationary in-home and mobile monitoring on people during their normal activities to evaluate exposure components and pathways contributing the greatest risk with the ultimate goal of developing mitigation strategies at individual and tribal levels to inform decisions and policies to reduce the risks linked to increasing cancer and other chronic disease disparities in these communities. The resulting fine-scale predictive models, ground-truthed through monitoring, and the integration of multiple exposure streams will provide a resource to not only inform policy, but aid clinicians in identifying early risks to develop prevention strategies as well.

摘要：总体 - 本土环境健康研究公平中心美国近一半的美洲原住民居住在西部 13 个州附近估计有 161,000 个废弃的硬岩矿，其中超过 4,000 个是废弃的铀矿。由于他们依赖自然资源来维持传统饮食、生活方式、习俗和语言，这些部落社区经常直接接触来自废弃矿场的金属混合物，通过多种途径产生暴露，包括吸入、饮用水和摄入食物废物迁移造成的直接或间接污染加剧了这些暴露的差异。基础设施，包括安全饮用水和固体废物管理等服务。历史上，废物管理导致固体废物的焚烧和露天倾倒，但随着进入废物流的塑料数量不断增加，这些塑料的低温、不完全燃烧过程以及风化造成的环境退化，我们的部落伙伴越来越担心关于塑料有毒降解产物如何排放到环境中的担忧。这些过程中产生的组合毒物以及我们已经发现与免疫功能障碍有关的金属这些社区促成了本机 EH 股权提案的第二阶段，我们发现了金属混合物的结果。我们三个合作土著社区的不同暴露情况：纳瓦霍族、Apsáalooke 和虽然我们看到这些社区免疫功能障碍的共性。尽管金属暴露本身并不会导致癌症和其他慢性疾病的差异因此，在第二阶段中心，我们将深入了解新兴的风险。额外的塑料降解污染物概况，评估微塑料的成分和分布以及其他降解产物，以及采掘业的排放，可能会增加这些类别我们将监测牲畜的放牧模式。以及通过空气、植物和水的消耗以及家庭固定装置所产生的暴露对人们的正常活动进行移动监测，以评估暴露成分和途径贡献最大的风险，最终目标是制定个人和部落的缓解策略为决策和政策提供信息，以减少与癌症和其他慢性疾病增加相关的风险由此产生的精细预测模型，通过地面验证。监控以及多个曝光流的整合将提供资源，不仅可以为政策提供信息，但也有助于识别早期风险以制定预防策略。