A Rodent Physiologic Analysis and Recording System

啮齿动物生理分析和记录系统

• 批准号: 10009486
• 负责人: Brian R Clark
• 金额: $ 73.75万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10009486
• 关键词: Ammonia; Animal Model; Animals; Applications Grants; Architecture; Archives; Area; Behavior; Carbon Dioxide; Charge; Computer software; Conscious; Custom; Data; Data Collection; Data Display; Data Sources; Databases; Development; Devices; Docking; Dorsal; Engineering; Environment; Environmental Monitoring; Estrogen receptor positive; Evaluation; Freedom; Future; Gases; Goals; Graph; Heart Rate; Humidity; Internet; Laboratory Animal Production and Facilities; Lithium; Measurement; Measures; Modality; Monitor; Motion; Mus; Network Communication Protocols; Operative Surgical Procedures; Phase; Physiological; Polymers; Process; Protocols documentation; Rattus; Research; Research Design; Research Personnel; Resistance; Rodent; Running; Sampling; Schedule; Skin Temperature; Small Business Innovation Research Grant; Software Design; Suction; Surface; System; Tablet Computer; Tablets; Technology; Temperature; Time; Validation; Vertebrates; Veterinarians; Visual; Wireless Technology; analog; animal care; base; behavioral study; cost; data access; data streams; design; experimental study; implantation; improved; instrumentation; light weight; monitoring device; non-Native; non-invasive monitor; novel; open source; programs; prototype; remote sensor; respiratory; response; sensor; tool; usability; virtual; wireless communication; wireless network

Project Summary/Abstract The proposed research program focuses on the development and validation of the Rodent Physiologic Analysis and Recording (RODAR) System. The RODAR system embodies a wireless, noninvasive data collection, vi- sualization, and storage solution for monitoring animals' physiological status, behavior, and environment. The RODAR system o ers continuous or intermittent recording, synchronization, and real-time display of physiologic data including: heart rate, respiratory rate, activity, and skin temperature, and environmental data including: ambient temperature, humidity, ammonia, carbon dioxide, and other gases. The system also includes wireless \bridge" modules that will allow third-party or custom-made sensors to be integrated seamlessly into the wireless RODAR framework. Physiologic data are collected via miniature, lightweight Remote Physiologic Modules (RPMs) that are worn on the dorsal surface of the animal, with sensors integrated into an adjustable, chew-resistant jacket with a minimal form factor. The jacket is easily placed on the animal and features a rechargeable battery that can be replaced without removing the jacket. Both washable and disposable varieties of jacket will be available. Environmental data are collected using wireless, chew-proof Remote Environment Modules (REMs) that can be placed in living quarters or experimental environments. Remote Bridge Modules (RBMs) will be available that can accept arbitrary analog inputs (e.g., from third-party or custom sensors) and seamlessly integrate such data with native RODAR sensors. This capability allows a wide range of sensing modalities to operate as \nodes" wirelessly within the RODAR framework. All data collected by the RPMs, REMs, and RBMs are automatically time synchronized by the system. The RODAR system will enable simultaneous monitoring of up to 72 remote sensor modules (any combination of RPMs, REMs, and/or RBMs). Wireless videographic cameras can also be used with the RODAR system to enable visual monitoring and recording of the animals in real time. All RODAR remote unit data are transmitted wirelessly to a common receiver unit called the Hub. The Hub synchronizes the incoming data streams and relays the consolidated data to a PC using a standard network communications protocol. The PC can be local or remote, allowing experimental data to be viewed in real time from anywhere with an Internet connection. Software designed from the ground-up to be highly usable by researchers, technicians, and veterinarians provides both real-time and retrospective display of data, performs any additional processing that is desired, archives received data in a standard database format, and allows data collection protocols to be selected for the remote units. The RODAR system is a powerful, scalable, and extensible wireless architecture for noninvasive monitoring of animals' physiological status, behavior, and environmental conditions; it is also designed to facilitate the integration of additional sensor modalities as such technologies become available.

项目摘要/摘要 拟议的研究计划着重于啮齿动物生理分析的开发和验证 和录制（Rodar）系统。 Rodar系统体现了无线无创数据收集，VI- 用于监测动物的生理状态，行为和环境的储存解决方案。这 Rodar系统连续或间歇记录，同步和实时显示生理学 数据包括：心率，呼吸率，活动和皮肤温度以及环境数据，包括： 环境温度，湿度，氨，二氧化碳和其他气体。该系统还包括无线 \ bridge“将允许第三方或定制传感器无线集成到无线的模块 Rodar框架。 生理数据是通过磨损的微型，轻巧的远程生理模块（RPM）收集的 在动物的背侧表面，传感器集成到可调节的耐咀嚼夹克中 最小的外形。夹克很容易放在动物上，并配有可充电电池 在不卸下夹克的情况下更换。可洗外套的可洗和一次性品种。 环境数据是使用可以是无线的，防止咀嚼的远程环境模块（REMS）收集的 放置在居住区或实验环境中。远程桥模块（RBMS）将可用 可以接受任意模拟输入（例如，从第三方或自定义传感器），并无缝整合此类数据 带有原生Rodar传感器。这种能力允许广泛的感应方式作为\节点“” 在Rodar框架内无线。 RPM，REMS和RBM收集的所有数据都是自动的 时间由系统同步。 Rodar系统将同时监视多达72个遥控器 传感器模块（RPM，REMS和/或RBMS的任何组合）。无线录像机也可以是 与Rodar系统一起使用，以实时进行视觉监测和记录。 所有Rodar远程单元数据均无线传输到称为Hub的通用接收器单元。这 集线器将传入的数据流同步，并使用标准网络将合并数据传递到PC 通信协议。 PC可以是本地或遥控器，允许实际查看实验数据 从任何地方进行Internet连接的时间。从头开始设计的软件可由 研究人员，技术人员和兽医提供数据的实时和回顾性显示，可执行 所需的任何其他处理，档案以标准数据库格式接收到数据，并允许数据 为远程单元选择的收集协议。 Rodar系统是一种功能强大，可扩展且可扩展的无线体系结构，用于无创监视 动物的生理状况，行为和环境状况；它也旨在促进 随着这些技术的可用，其他传感器模式的集成。