NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 7715876
• 负责人: STEVEN G. KOHAMA
• 金额: $ 32.35万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715876
• 关键词: 17 year old; Age; Aging; Animals; Archives; Autopsy; Biological Markers; Biological Models; Breeding; Cognitive aging; Collection; Computer Retrieval of Information on Scientific Projects Database; Databases; Disease; Drug or chemical Tissue Distribution; Enrollment; Female; Funding; Future; Gender; Goals; Grant; Human; Individual; Institutes; Institution; Macaca mulatta; Maintenance; Menopause; Phenotype; Primates; Reporting; Research; Research Personnel; Resources; Sampling; Scientist; Source; Specimen; Tissue Banks; Tissues; United States National Institutes of Health; aged; animal resource; endometriosis; genetic pedigree; middle age; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. Individual animals are all Indian-derived, rhesus monkeys, with a gender ratio currently favoring females, reflecting harem breeding practices. Management includes: 1. Identification and tracking of middle-aged candidates for future enrollment; 2. Identification of animals with desirable phenotypes by scientists from all Divisions (the User's Group); 3. Coordination with the colony manager (Dr. Bland) of the Division of Animal Resources; and 4. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. For the latter, meetings have been held that deal with primate aging and biomarkers, menopause, endometriosis and cognitive aging. We also support the NIA Primate Aging Database (at WNPRC), and Tissue Bank (BioReliance). Tissue from aged animals has been distributed right from necropsy or from archives, to scientists internal and external to ONPRC. For example, archived samples were very useful for retrospective pedigree analysis of animals at the Center, since many of the aged animals were a part of the original Founder group.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 美国国家老龄化研究所 (NIA) 为 ONPRC 的 100 只老年（17 岁以上）非人类灵长类动物群体提供每日资助，称为灵长类动物老龄化研究 (PAS)。 PAS 群体的目标是为研究人员提供一个模型系统，以探索人类衰老和疾病的机制。个别动物都是源自印度的恒河猴，目前的性别比例有利于雌性，反映了后宫繁殖的做法。管理内容包括： 1、对中年考生进行识别和跟踪，以备将来招生； 2. 由各部门（用户组）的科学家鉴定具有理想表型的动物； 3.与动物资源处的群落管理员（Bland博士）协调； 4. 总体群体问题通过动物利用委员会进行讨论。 PAS 管理的其他方面还包括收集、存档和分发来自扑杀动物的组织标本，向 NIA 报告 PAS 使用情况，以及向 NIA 提供有关老龄灵长类动物研究利用问题的信息。对于后者，已经召开了一些会议来讨论灵长类衰老和生物标志物、更年期、子宫内膜异位症和认知衰老。我们还支持 NIA 灵长类动物衰老数据库（WNPRC）和组织库（BioReliance）。老年动物的组织从尸检或档案中直接分发给 ONPRC 内部和外部的科学家。例如，存档的样本对于中心动物的回顾性谱系分析非常有用，因为许多老年动物都是原始创始人群体的一部分。