NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 7958413
• 负责人: STEVEN G. KOHAMA
• 金额: $ 32.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958413
• 关键词: 17 year old; Aging; Animals; Archives; Biological; Biological Models; Breeding; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; District of Columbia; Drug or chemical Tissue Distribution; Enrollment; Ensure; Equilibrium; Female; Funding; Future; Goals; Grant; Head; Human; Institutes; Institution; Macaca mulatta; Mails; Maintenance; National Institute on Aging; Neurosciences; Paper; Persons; Primates; Reporting; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Role; Scientist; Societies; Source; Specimen; Telephone; United States National Institutes of Health; animal colony; animal resource; meetings; middle age; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are all Indian-derived, rhesus macaques with the majority being females, reflecting harem breeding practices. Management of the colony balances prognostication for immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. This is accomplished by interfacing with investigators and animal colony manager in the Division of Animal Resources. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. National concerns are coordinated through the Head of the NIA Office of Biological Resources and Resource Development, Dr. Nancy Nadon, either in person (Society for Neuroscience, 2008, Washington DC) and by phone calls and e-mail. A discussion with investigators outside of ONPRC, who also conduct aging research in nonhuman primates, was held at the AGE meeting held in Boulder, CO in 2008. Another role of the Aging Resource is the collection, archiving and distribution of tissue to scientists both locally and nationally (eg- see paper in press).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 美国国家老龄化研究所 (NIA) 为 ONPRC 的 100 只老年（17 岁以上）非人类灵长类动物群体提供每日资助，称为灵长类动物老龄化研究 (PAS)。 PAS 群体的目标是为研究人员提供一个模型系统，以探索人类衰老和疾病的机制。这些动物都是源自印度的恒河猴，其中大多数是雌性，反映了后宫繁殖的做法。 群体的管理平衡了对研究项目中近期使用的预测，并在必要时通过跟踪和招募中年候选人来确保持续的替代。 这是通过与动物资源部门的调查人员和动物群经理进行交流来完成的。 整体群体问题通过动物利用委员会进行讨论。 PAS 管理的其他方面还包括收集、存档和分发来自扑杀动物的组织标本，向 NIA 报告 PAS 使用情况，以及向 NIA 提供有关老龄灵长类动物研究利用问题的信息。 国家关注的问题通过 NIA 生物资源和资源开发办公室主任 Nancy Nadon 博士进行协调，可以亲自协调（神经科学学会，2008 年，华盛顿特区），也可以通过电话和电子邮件进行协调。 2008 年在科罗拉多州博尔德举行的 AGE 会议上，与 ONPRC 以外的研究人员进行了讨论，这些研究人员也在非人类灵长类动物中进行衰老研究。老龄化资源的另一个作用是收集、存档和向当地科学家分发组织和全国范围内（例如-参见印刷中的论文）。