NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 8173184
• 负责人: STEVEN G. KOHAMA
• 金额: $ 33.19万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173184
• 关键词: 17 year old; Age; Aging; Animals; Archives; Biological Models; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Female; Funding; Future; Goals; Grant; Human; Institutes; Institution; Macaca mulatta; Maintenance; National Institute on Aging; Primates; Reporting; Research; Research Personnel; Research Project Grants; Resources; Services; Source; Specimen; United States National Institutes of Health; animal resource; male; middle age; nonhuman primate; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are Indian-derived, male and female rhesus macaques with management of the colony reflecting immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. Management issues are discussedwith the Division of Animal Resources, the Animal Utilization Committee, as well as with the Aging Working Group. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. This resource is making good progress in the maintenance and allocation of animals as well as archival services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 美国国家老龄化研究所 (NIA) 为 ONPRC 的 100 只老年（17 岁以上）非人类灵长类动物群体提供每日资助，称为灵长类动物老龄化研究 (PAS)。 PAS 群体的目标是为研究人员提供一个模型系统，以探索人类衰老和疾病的机制。这些动物是来自印度的雄性和雌性恒河猴，对群体的管理反映了未来在研究项目中的使用，并在必要时通过跟踪和招募中年候选人来确保不断更换。 管理问题与动物资源司、动物利用委员会以及老龄化工作组进行讨论。 PAS 管理的其他方面还包括收集、存档和分发来自扑杀动物的组织标本，向 NIA 报告 PAS 使用情况，以及向 NIA 提供有关老龄灵长类动物研究利用问题的信息。该资源在动物的维护和分配以及档案服务方面取得了良好进展。