CE19-001, The Penn Injury Science Center

CE19-001，宾夕法尼亚州损伤科学中心

• 批准号: 10054921
• 负责人: DOUGLAS J WIEBE
• 金额: $ 84.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054921
• 关键词: CE19; 001; Penn; Injury; Science

PROJECT SUMMARY We propose the Penn Injury Science Center (PISC) as an ICRC at the University of Pennsylvania (Penn) focusing on the reduction of injuries and violence through the highest caliber science, education, and outreach that addresses the intersecting impacts of risk and protective exposures across space and time. Our research ranges in geographic and temporal scale from broad to highly granular, and we study vulnerable populations at scales ranging from a precise within-person or within-activity level to a broad macro or policy level depending on the nature of the injury and violence scenario that is at issue and the state of evidence in that area of injury science. Most injury or violence events have multiple component causes. Our space-time lens helps us appreciate the complexity of injury prevention science and use that understanding to hone in on the determinants and points of intervention that, if targeted, would allow us to achieve the greatest injury prevention impact. Our space-time approach acknowledges that we may never be aware of some of the exposures that contribute to cause an injury and that, even among identified exposures, some may not be measureable. But, by appreciating the complexity of injury events, we are better able to target the risk factors that are the most amenable to change and, likewise, the protective factors that are most feasible to promote. The goal of the PISC is to promote and perform the highest quality research, training, and translation of scientific discoveries into practice and policy, in order to reduce injuries, violence, and their impact nationwide, particularly among vulnerable and underserved populations. Populations may be vulnerable or underserved due to many factors, including the places they live, work and spend time, sports they play, the policies of the state where they live, structural racism, and many other factors. Hence the focus of the injury prevention science led by PISC investigators addresses topics and populations in many contexts and geographic locations. The proposed Center is organized around 4 Cores (the Administrative Core, the Outreach Core, the Training and Education Core, and the Research Core) with support and input from Internal and External Advisory Boards, and a Community Action Board. The Center has proposed 4 fully developed Research Projects in this application and will support an Exploratory Grant Program to fund pilot research in injury and violence prevention priority areas. The Research Projects include a translational implementation trial towards improving warm handoff pathways for opioid use disorder, reducing motor vehicle crashes in newly licensed drivers, applying innovative technology to reduce falls in older adults, and examining the intersection of adverse childhood experiences (ACEs) and neighborhood exposures on health and injury outcomes. The PISC leadership, faculty, trainees, and partners, thus, will collaborate to conduct important research, training, and translation activities that engage the Penn community and local and national stakeholders in implementing and advancing a fully funded and sustainable comprehensive ICRC.

项目概要 我们提议将宾夕法尼亚州伤害科学中心 (PISC) 作为红十字国际委员会设在宾夕法尼亚大学（宾夕法尼亚州） 重点通过最高水平的科学、教育和技术减少伤害和暴力 解决跨空间和保护性风险的交叉影响的外展活动 时间。我们的研究范围涵盖地理和时间尺度，从广泛到精细，我们研究 弱势群体的范围从精确的人内或活动内水平到广泛的宏观水平 或政策级别取决于所涉及的伤害和暴力情况的性质以及情况 伤害科学领域的证据。大多数伤害或暴力事件都有多种原因。我们的 时空透镜帮助我们理解伤害预防科学的复杂性并利用它 理解磨练干预的决定因素和要点，如果有针对性的话，将允许 我们实现最大的伤害预防效果。我们的时空方法承认我们可以 永远不要意识到某些会导致伤害的暴露，即使是在已识别的人群中 暴露，有些可能无法测量。但是，通过了解伤害事件的复杂性，我们可以做得更好 能够针对最容易改变的风险因素，以及同样的保护因素 是最有可能推广的。 PISC 的目标是促进和开展最高质量的研究， 培训，并将科学发现转化为实践和政策，以减少伤害、暴力、 及其在全国范围内的影响，特别是对弱势和服务不足的人群的影响。人群可能是 由于许多因素，包括他们居住、工作和消磨时间的地方、运动等，他们处于弱势或服务不足 他们玩的游戏、他们所居住国家的政策、结构性种族主义以及许多其他因素。因此重点 由 PISC 调查员领导的伤害预防科学研究涉及多种背景下的主题和人群 和地理位置。拟议的中心围绕 4 个核心（行政核心、 外展核心、培训和教育核心以及研究核心）在内部的支持和投入下 和外部咨询委员会以及社区行动委员会。该中心提出了4个全面开发 本申请中的研究项目并将支持探索性资助计划，以资助以下领域的试点研究 伤害和暴力预防优先领域。研究项目包括转化实施试验 改善阿片类药物使用障碍的温暖交接途径，减少新近发生的机动车事故 有执照的司机，应用创新技术来减少老年人跌倒，并检查十字路口 不良童年经历（ACE）和邻里接触对健康和伤害结果的影响。这 因此，PISC 领导层、教师、学员和合作伙伴将合作开展重要的研究， 吸引宾夕法尼亚大学社区以及地方和国家参与的培训和翻译活动 利益攸关方实施和推进资金充足且可持续的综合性红十字国际委员会。