CE19-001, The Penn Injury Science Center

CE19-001，宾夕法尼亚州损伤科学中心

• 批准号: 10451463
• 负责人: DOUGLAS J WIEBE
• 金额: $ 84.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451463
• 关键词: CE19; 001; Penn; Injury; Science

PROJECT SUMMARY We propose the Penn Injury Science Center (PISC) as an ICRC at the University of Pennsylvania (Penn) focusing on the reduction of injuries and violence through the highest caliber science, education, and outreach that addresses the intersecting impacts of risk and protective exposures across space and time. Our research ranges in geographic and temporal scale from broad to highly granular, and we study vulnerable populations at scales ranging from a precise within-person or within-activity level to a broad macro or policy level depending on the nature of the injury and violence scenario that is at issue and the state of evidence in that area of injury science. Most injury or violence events have multiple component causes. Our space-time lens helps us appreciate the complexity of injury prevention science and use that understanding to hone in on the determinants and points of intervention that, if targeted, would allow us to achieve the greatest injury prevention impact. Our space-time approach acknowledges that we may never be aware of some of the exposures that contribute to cause an injury and that, even among identified exposures, some may not be measureable. But, by appreciating the complexity of injury events, we are better able to target the risk factors that are the most amenable to change and, likewise, the protective factors that are most feasible to promote. The goal of the PISC is to promote and perform the highest quality research, training, and translation of scientific discoveries into practice and policy, in order to reduce injuries, violence, and their impact nationwide, particularly among vulnerable and underserved populations. Populations may be vulnerable or underserved due to many factors, including the places they live, work and spend time, sports they play, the policies of the state where they live, structural racism, and many other factors. Hence the focus of the injury prevention science led by PISC investigators addresses topics and populations in many contexts and geographic locations. The proposed Center is organized around 4 Cores (the Administrative Core, the Outreach Core, the Training and Education Core, and the Research Core) with support and input from Internal and External Advisory Boards, and a Community Action Board. The Center has proposed 4 fully developed Research Projects in this application and will support an Exploratory Grant Program to fund pilot research in injury and violence prevention priority areas. The Research Projects include a translational implementation trial towards improving warm handoff pathways for opioid use disorder, reducing motor vehicle crashes in newly licensed drivers, applying innovative technology to reduce falls in older adults, and examining the intersection of adverse childhood experiences (ACEs) and neighborhood exposures on health and injury outcomes. The PISC leadership, faculty, trainees, and partners, thus, will collaborate to conduct important research, training, and translation activities that engage the Penn community and local and national stakeholders in implementing and advancing a fully funded and sustainable comprehensive ICRC.

项目摘要 我们建议宾夕法尼亚大学（Pennsylvania大学（PENN））作为ICRC宾夕法尼亚州伤害科学中心（PISC） 通过最高才能的科学，教育和 宣传，以解决风险和保护性暴露的相交影响，以及 时间。我们的研究范围从广泛到高度颗粒状的地理和时间量表范围，我们研究 从精确的人内或活动水平到广泛的宏 或政策层面，具体取决于处于争议的伤害和暴力情况的性质和状态 伤害科学领域的证据。大多数伤害或暴力事件都有多个组成原因。我们的 时空镜头有助于我们欣赏预防伤害科学的复杂性，并使用 理解以磨练决定因素和干预点，如果有针对性的， 我们要获得最大的伤害预防影响。我们的时空方法承认我们可能 永远不要意识到有助于造成伤害的某些暴露，即使在被确定的 暴露，有些可能无法衡量。但是，通过欣赏伤害事件的复杂性，我们会更好 能够针对最适合改变的危险因素，同样是保护因素 最可行的促进。 PISC的目标是促进和执行最高质量的研究， 培训和将科学发现转化为实践和政策，以减少伤害，暴力， 及其在全国范围内的影响，尤其是在脆弱和服务不足的人群中。人口可能是 由于许多因素，包括他们居住，工作和度过的时间，体育运动，易受伤害或服务不足 他们扮演的是居住的国家政策，结构性种族主义以及许多其他因素。因此，重点 PISC调查人员领导的伤害预防科学在许多情况下介绍了主题和人群 和地理位置。拟议的中心组织了大约4个核心（行政核心， 外展核心，培训和教育核心以及研究核心），内部的支持和投入 和外部咨询委员会和社区行动委员会。该中心已提出4个完全开发的 本应用程序中的研究项目，并将支持探索性赠款计划，以资助试点研究 伤害和暴力预防优先领域。研究项目包括翻译实施试验 为了改善阿片类药物使用障碍的温暖交接道，减少了新的汽车撞车事故 有执照的驾驶员，采用创新技术来减少老年人的跌倒，并检查十字路口 不利的童年经历（ACE）和有关健康和伤害结果的邻里暴露。这 因此 培训和翻译活动，吸引宾夕法尼亚社区以及地方和国家 利益相关者在实施和推进全面资助和可持续的全面ICRC方面。