Data Coordinating Core

数据协调核心

• 批准号: 10024095
• 负责人: DOUGLAS J WIEBE
• 金额: $ 16.95万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10024095
• 关键词: Age; Alzheimer' s Disease; Brain; Clinical Data; Clinical assessments; Collaborations; Common Data Element; Communities; Data; Data Analyses; Data Element; Data Linkages; Data Reporting; Development; Informatics; Injury; Institution; Laboratories; Link; Mind; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neurodegenerative Disorders; Parkinson Disease; Phase; Population; Recovery; Research; Research Personnel; Research Project Grants; Severities; Site; Standardization; System; Traumatic Brain Injury; central database; chronic traumatic encephalopathy; data archive; data infrastructure; data sharing; data warehouse; design; digital; patient population; repository; response

Data Coordinating Core SUMMARY A key factor which has hindered research into TBI related neurodegeneration (TReND) is the narrow focus on chronic traumatic encephalopathy (CTE) with far less consideration given to the broader group of neuropathological effects of TBI. Indeed, most TReND research efforts involve a single, localized population and are conducted at a single site; furthermore, the data derived is largely unavailable to the broader community. As has been demonstrated in related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, broad, coordinated, and multi-institution efforts bolster the quality of research by drawing data from multiple populations. To achieve this for the TBI research community, the CONNECT-TBI Data Coordinating Core will focus its efforts on the establishing central, standardized, and reliable handling of all data relating to the Research Projects. Through close interaction with the Administrative and Brain Bank Core, a central repository of all neuropathological and clinical data will be made available to all authorized investigators. This Core intends to implement the NINDS established sets of Common Data Elements (CDEs) to characterize TBI at local sites and compile these data in the central database.

数据协调核心 概括 阻碍TBI相关神经退行性研究（趋势）的研究的关键因素是对 慢性创伤性脑病（CTE），对更广泛的群体的考虑要少得多 TBI的神经病理学作用。确实，大多数趋势研究工作涉及一个本地人群 并在一个地点进行；此外，得出的数据在很大程度上不可用 社区。如在相关的神经退行性疾病中所证明的，例如阿尔茨海默氏症和 帕金森氏病，广泛，协调和多机构的努力通过绘画来增强研究质量 来自多个人群的数据。为了为TBI研究社区实现这一目标，连接TBI数据 协调核心将把精力集中在建立中央，标准化和可靠的处理上 与研究项目有关的数据。通过与行政和脑库核心的密切互动， 所有神经病理学和临床数据的中央存储库都将提供给所有授权 调查人员。该核心打算实施NINDS已建立的一组常见数据元素（CDE） 在本地站点表征TBI并在中央数据库中编译这些数据。