Fetal Exposure to Environmental Toxicants and Child Outcome

胎儿接触环境毒物和儿童结局

基本信息

批准号：
7596434
负责人：
Enrique Mapua Ostrea
金额：
$ 55.6万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7596434
关键词：
2 year old 6 year old Address Adolescence Adverse effects Affect Age Age-Years Alcohols Animals Area Attention Behavior Behavioral Biological Markers Birth Blood Brain Carbamates Caregivers Chemicals Child Child Development Childhood Cognition Cohort Studies Collaborations Data Data Analyses Detection Developed Countries Developing Countries Development Discipline Doctor of Medicine Doctor of Philosophy Drug usage Environment Etiology Evaluation Evolution Exhibits Exposure to Family Study Filipino Funding Goals Growth Hair Health Sciences High Prevalence Home environment House Dust Household Human Illicit Drugs Infant Insecticides Institution Intelligence Interdisciplinary Study International Laboratories Lead Learning Letters Life Long-Term Effects Longitudinal Studies Mass Fragmentography Measurement Measures Meconium Memory Mercury Methods Michigan Monitor Motor Skills Neurodevelopmental Deficit Neurodevelopmental Problem Neurotoxins Newborn Infant Nursery Schools Oregon Outcome Outcome Measure Outcome Study Parents Participant Performance Perinatal Exposure Pesticides Philippines Population Study Positioning Attribute Pregnancy Pregnant Women Prevalence Preventive Intervention Propoxur Psychologist Psychopathology Public Health Recording of previous events Research Research Personnel Sample Size Sampling School-Age Population Secondary to Site Social support Socioeconomic Status Staging System Testing Toxic Environmental Substances Toxic effect Umbilical Cord Blood United States United States National Institutes of Health Universities University Hospitals Violence Virginia Xenobiotics bioallethrin carbamate insecticide cohort critical period cyfluthrin cypermethrin design drug testing early childhood executive function experience follow-up in utero innovation insight interest member mental development method development neurobehavioral neurobehavioral test neurodevelopment neurotoxic pesticide exposure postnatal prenatal prenatal exposure public health relevance pyrethroid self help skills success tool

项目摘要

DESCRIPTION (provided by applicant): There is widespread use and exposure of pregnant women and their infants to pesticides but limited data is available on the long term effects of these neurotoxicants on the growth and neurodevelopment of the children. We propose to continue the longitudinal study (up to age 6 years) of our cohort (N=754) of infants, a high percentage of whom were antenatally exposed to propoxur, bioallethrin, cyfluthrin and cypermethrin (heretofore referred to as pesticides). We have tested these infants up to 2 years of age using the Fagan Test of Infant Intelligence and Griffiths' Mental Development Scales. At 2 years, neurobehavioral testing revealed a significant decrease in Griffiths performance in association with prenatal exposure of the infants, particularly to propoxur. We intend to study the progress of these deficits and to uncover any delayed neurotoxic effects of pesticide exposure in these children. AIMS: (1) To examine the relationship between antenatal exposure to pesticides and neurobehavioral development of children at 4 and 6 years of age, (2) To examine the relationship between postnatal exposure to pesticides, as measured by analysis of house dust and children's hair, and neurobehavioral development of children at 4 and 6 years, and (3) To examine the relationship between prenatal and postnatal exposure to pesticides and neurobehavioral development at 4 and 6 years. We hypothesize that there will be more neurodevelopmental deficits associated with prenatal or postnatal exposure to pesticides compared to the unexposed group and the deficits will be more pronounced with both pre- and postnatal exposures. METHODS: At 4 and 6 years of age, hair from children in our ongoing study cohort, as well as house dust from their homes, will be collected and analyzed for pesticides by gas chromatography/ mass spectrometry to detect ongoing exposure. The children will be tested at 4 and 6 years with a battery of tests which assess: (1) General cognition, (2) Attention & executive function, (3) Memory, (4) Behavior and (5) Self help. These tests explore the domains and functions of the brain that are affected by pesticides in animal and human studies. DATA ANALYSIS: The outcome measures from these tests will be correlated, after adjustment for confounders, to pre- and/or postnatal exposure to pesticides. PUBLIC HEALTH RELEVANCE: This study utilizes a large cohort of infants for whom we have data on prenatal and early childhood pesticide exposure, as well as assessments of growth and neurodevelopment from birth up to 2 years of age, with a 95% follow up rate. The study is important and relevant to public health since it will provide important and much needed information on the longitudinal, adverse effects on the growth and neurodevelopment of children of carbamates and pyrethroids, which are now widely used. The study is important and relevant to public health since it will provide important and much needed information on the longitudinal, adverse effects on the growth and neurodevelopment of children of carbamates and pyrethroids, which are now widely used.

描述（由申请人提供）：孕妇及其婴儿广泛使用和接触农药，但有关这些神经毒物对儿童生长和神经发育的长期影响的数据有限。我们建议继续对我们的婴儿队列（N=754）进行纵向研究（直至 6 岁），其中很大一部分婴儿在产前接触过残杀威、生物烯丙菊酯、氟氯氰菊酯和氯氰菊酯（此前称为农药）。我们使用费根婴儿智力测试和格里菲斯心理发展量表对这些 2 岁以下的婴儿进行了测试。 2岁时，神经行为测试显示格里菲斯的表现显着下降与婴儿产前接触，特别是残杀威有关。我们打算研究这些缺陷的进展，并揭示这些儿童接触农药所产生的延迟神经毒性效应。目的：(1) 研究产前接触农药与 4 岁和 6 岁儿童神经行为发育之间的关系，(2) 通过分析室内灰尘和儿童头发来研究产后接触农药之间的关系，以及 4 岁和 6 岁时儿童的神经行为发育，以及 (3) 研究产前和产后接触农药与 4 岁和 6 岁时神经行为发育之间的关系。我们假设，与未接触农药的组相比，产前或产后接触农药会导致更多的神经发育缺陷，并且产前和产后接触农药时缺陷会更加明显。方法：在我们正在进行的研究队列中，我们将收集 4 岁和 6 岁儿童的头发以及他们家中的室内灰尘，并通过气相色谱/质谱法分析农药，以检测持续的接触情况。孩子们将在 4 岁和 6 岁时接受一系列测试，评估：(1) 一般认知、(2) 注意力和执行功能、(3) 记忆、(4) 行为和 (5) 自助。这些测试探讨了动物和人类研究中受农药影响的大脑领域和功能。数据分析：在调整混杂因素后，这些测试的结果测量将与产前和/或产后接触农药的情况相关。公共健康相关性：这项研究利用了一大群婴儿，我们拥有这些婴儿的产前和幼儿期农药接触数据，以及从出生到 2 岁的生长和神经发育评估，随访率为 95%。这项研究对于公共卫生具有重要意义和相关性，因为它将提供有关目前广泛使用的氨基甲酸酯和拟除虫菊酯对儿童生长和神经发育的纵向不利影响的重要且急需的信息。这项研究对于公共卫生具有重要意义和相关性，因为它将提供有关目前广泛使用的氨基甲酸酯和拟除虫菊酯对儿童生长和神经发育的纵向不利影响的重要且急需的信息。