Pilot Projects

试点项目

• 批准号: 10006840
• 负责人: Ralph C Budd
• 金额: $ 44.7万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-05 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006840
• 关键词: Advisory Committees; Autoimmune Diseases; Award; Basic Science; Biology; Biomedical Research; Categories; Centers of Research Excellence; Collaborations; Commercial Sectors; Communicable Diseases; Computer Models; Core Facility; Data; Development; Diagnostic; Evaluation; Experimental Designs; Faculty; Fostering; Funding; Future; Goals; Grant; Guidelines; Immune response; Immune system; Immunobiology; Immunology; Individual; Infection; Infectious Diseases Research; Interdisciplinary Study; Lung; Mentors; Metabolic; Microbiology; Oral; Parasites; Phase; Pilot Projects; Predisposition; Process; Publications; Research; Research Personnel; Science; Secure; Sex Differences; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Therapeutic; Time; Translational Research; United States National Institutes of Health; Vermont; Viral; Vision; base; commercialization; design; immunoregulation; medical schools; meetings; preference; programs; small molecule; success; translational diagnostics; trend; working group

SUMMARY for the Pilot Project Program The design of the Pilot Project Program is based on the long-term vision of enhancing the scientific pace, collaboration, and competitiveness of the Vermont Center for Immunology and Infectious Diseases (VCIID). This is consistent with our overall objective of the Phase III COBRE program to promote the transition to an independent sustainable center that can compete for collaborative R01, P01, U19, and SBIR/STTR grants. Based on our developed research expertise during Phases I and II, and national trends in biomedical research, we have designed three categories of Pilots Projects to expand the VCIID's research portfolio: i) basic research in immunology or microbiology, ii) translational research, and iii) an entrepreneurial SPARK-VT Program to move ideas from basic research into the commercial sector through diagnostic or therapeutic platforms. Emphasis among these three categories will be given to junior investigators and collaborations, both within VCIID COBRE faculty as well as with other COBRE programs, such as the Vermont Lung Center (VLC) or the nearby Geisel/Dartmouth Medical School COBRE in Immunology/Microbiology. A rigorous application and review process will be implemented using NIH guidelines to identify the most meritorious science, and to select applicants with the greatest potential for long-term success. In addition, the Pilot Project Program will be responsive to the needs of junior faculty by providing them with a more favorable pay line, and assigned mentoring. The Specific Aims are thus: Specific Aim 1. Implement a Pilot Project Program. We will provide Pilot Project funds to VCIID faculty to secure critical data for new grants, with emphasis on collaborations with investigators in this and other COBRE programs, use of core facilities, and with the provision of personalized mentoring. Specific Aim 2. Provide rigorous evaluation of Pilot Projects to promote publications and grant submissions. We will use an NIH format of written applications followed by oral presentations of the most meritorious to the External Advisory Committee (EAC). Among those with high scientific merit, preference will be given for junior faculty and collaborating faculty. Specific Aim 3. Foster P01/U-19 working groups around common research themes of the Pilot Project Grants. Working groups with appointed leaders have been formed around common research themes in i) viral immunology, ii) metabolic regulation of the immune response, iii) computational modeling of the immune system, iv) small molecule targets for parasites, and v) sex differences in susceptibility to infectious and autoimmune diseases. These groups could receive pilot funding to get critical data needed for collaborative R01, P01, U19, or SBIR/STTR grants.

试点项目的摘要 试点项目计划的设计基于增强科学速度的长期愿景， 佛蒙特州免疫和传染病中心（VCIID）的合作和竞争力。 这与我们第三阶段毛线计划的整体目标是一致的，以促进过渡到 可以争夺合作R01，P01，U19和SBIR/STTR赠款的独立可持续性中心。 基于我们在I和II阶段发达的研究专业知识，以及生物医学研究的国家趋势， 我们设计了三类试点项目来扩展VCIID的研究组合：i）基本 免疫学或微生物学研究，ii）转化研究，iii）企业家Spark-VT 通过诊断或治疗的计划将思想从基础研究转移到商业部门 平台。这三个类别将重点放在初级调查人员和合作中， 在VCIID COBRE教职员工以及其他毛线计划中，例如佛蒙特州肺中心 （VLC）或附近的Geisel/Dartmouth医学院的免疫学/微生物学。严格 申请和审查过程将使用NIH指南实施，以确定最有功的 科学，并选择具有长期成功潜力的最大潜力的申请人。此外，飞行员项目 课程将通过为初级教师提供更有利的薪资线和 分配的指导。因此，具体目标是： 具体目标1。实施试点项目计划。我们将向VCIID教师提供试点项目资金 确保新赠款的关键数据，重点是与调查人员合作和其他毛绒 程序，核心设施的使用以及提供个性化指导。 具体目标2。对试点项目进行严格评估以促进出版物和授予 提交。我们将使用书面申请的NIH格式，然后是最多的口头介绍 对外部咨询委员会（EAC）的荣誉。在具有高科学优点的人中，偏爱 为初级教师和合作教师提供。 特定目的3。寄养P01/U-19 赠款。在i）病毒中围绕着具有指定领导者的工作组成立了 免疫学，ii）免疫反应的代谢调节，ii）免疫的计算建模 系统，iv）寄生虫的小分子靶标，v）感染性和 自身免疫性疾病。这些小组可以收到试点资金，以获取协作所需的关键数据 R01，P01，U19或SBIR/STTR赠款。