Vermont Center for Immunobiology/Infectious Diseases (VCIID)

佛蒙特州免疫生物学/传染病中心 (VCIID)

基本信息

批准号：
10395160
负责人：
Ralph C Budd
金额：
$ 30.89万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10395160
关键词：
Address Affect Animal Model Apoptosis Apoptotic Architecture Atmosphere Autoimmune Autoimmune Diseases Autoimmunity Award Basic Science Biological Biology Bone Marrow CNS autoimmune disease Cell physiology Cells Centers of Research Excellence Chimera organism Chronic Chronic Disease Clinical assessments Collaborations Communicable Diseases Core Facility Coupled Data Demyelinating Diseases Development Discipline of obstetrics Disease Estrogen Receptor alpha Estrogen Receptor beta Estrogen Receptors Estrogens Estrous Cycle Excision Experimental Autoimmune Encephalomyelitis Faculty Female Flow Cytometry Fostering Functional disorder Funding Future Gene Expression Profiling Gene Targeting Genetic Goals Gonadal Steroid Hormones Gynecology Immune Immune response Immune system Immunobiology Immunology Incidence Infection Inflammation Inflammatory Investigation Knockout Mice Lead Libido Lupus Mentors Microglia Mitogen-Activated Protein Kinases Modeling Molecular Multiple Sclerosis Mus Myelogenous Myeloid Cells Neuraxis Nuclear Receptors Organ Ovarian Ovarian Follicle Ovary Parents Pathogenesis Pathology Pathway interactions Phagocytes Phase Phenotype Physicians Pilot Projects Polycystic Ovary Syndrome Positioning Attribute Prevalence Process Publishing Receptor Signaling Regulation Reproductive Physiology Reproductive Sciences Research Research Personnel Research Project Grants Role Scientist Severity of illness Sex Differences Side Signal Transduction Strategic Planning Talents Testing Time Tissues United States National Institutes of Health Universities Vermont Woman Women&apos s Health cell type conditional knockout granulosa cell immune function in vitro Model in vivo insight interdisciplinary collaboration interest macrophage member microbial mouse model multidisciplinary primary ovarian insufficiency ranpirnase receptor reproductive reproductive function reproductive hormone reproductive organ response sex tool

项目摘要

Abstract: scope of parent award and relevance to the NOSI on women's health The parent award, P30 GM118228, COBRE Phase III, supports the Vermont Center for Immunology and Infectious Diseases (VCIID) at the University of Vermont (UVM). The VCIID represents a multidisciplinary group of scientists and clinicians undertaking collaborative research in basic immunology, autoimmunity, microbial pathogenesis, and host response to infections. The keystone of the VCIID is scientific excellence through dedicated mentoring of talented junior faculty in an atmosphere that is both engaging and rigorous. In Phase III we seek to coalesce our mutual interests along research lines that will maintain our competitiveness and encourage basic, translational, and entrepreneurial research projects. We will foster this effort through the support of Pilot Project and Core Facilities, and administrative support. This Supplement Application represents a collaboration between two VCIID faculty members who are basic researchers, and two physician-scientists in the department of Department of Obstetrics, Gynecology and Reproductive Sciences. On both sides, there is a junior investigator paired with a senior investigator (respectively: Dr. Krementsov and Dr. Teuscher from VCIID; Dr. Brodeur and Dr. McGee from Ob-Gyn), which fits with VCIID's goal of support for junior faculty, as well as cross-departmental and interdisciplinary collaboration. The scientific goals of this Supplement Application are to investigate the mechanisms regulating innate immune cell functionality in the context of autoimmune disease and normal reproductive function. As such, this fits well within the scope of the VCIID, which supports basic immunology and autoimmunity research. With regard to relevance to women's health, in this supplement application, we propose a basic science approach to dissect molecular mechanisms whereby female reproductive hormones regulate immune cell function in the context of: 1) an autoimmune disease (MS, with highly biased incidence in females), and 2) female reproductive organ function. The NOSI states that the “proposed research must address at least one of the strategic goals of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research”. Our proposed research will address Strategic Objectives 1.1 (basic biology of sex differences), 1.2 (influence of sex on disease), and 1.5 (research on female reproductive function).

摘要：家长奖励的范围以及与 NOSI 妇女健康的相关性家长奖 P30 GM118228，COBRE III 期，支持佛蒙特州免疫学中心和佛蒙特大学 (UVM) 传染病 (VCIID) VCIID 代表一个多学科小组。基础免疫学、自身免疫学、微生物学领域的科学家和雄心勃勃的合作研究 VCIID 的基石是通过科学的卓越性。在第三阶段，在既有吸引力又严谨的氛围中对有才华的初级教师进行专门指导。我们寻求沿着研究方向结合我们的共同利益，以保持我们的竞争力和我们将通过以下方式鼓励基础、转化和创业研究项目。试点项目和核心设施的支持以及行政支持。此补充应用程序代表了两名具有基础知识的 VCIID 教员之间的合作妇产科的研究人员和两名医师科学家生殖科学两侧各有一名初级研究员和一名高级研究员。（分别：来自 VCIID 的 Krementsov 博士和 Teuscher 博士；来自 Ob-Gyn 的 Brodeur 博士和 McGee 博士）符合 VCIID 支持初级教师以及跨部门和跨学科的目标该补充申请的科学目标是研究调节机制。自身免疫性疾病和正常生殖功能中的先天免疫细胞功能。这非常适合 VCIID 的范围，它支持基础免疫学和自身免疫研究。关于与女性健康的相关性，在这个补充申请中，我们提出了一个基础科学剖析女性生殖激素调节免疫细胞的分子机制的方法在以下情况下发挥作用：1) 自身免疫性疾病（MS，女性发病率高度偏向），2) 女性 NOSI 指出，“拟议的研究必须至少解决其中一项问题”。 2019-2023 年跨 NIH 女性健康研究战略计划的战略目标”。研究将涉及战略目标 1.1（性别差异的基本生物学）、1.2（性别对性别差异的影响）疾病）和1.5（女性生殖功能研究）。

项目成果

期刊论文数量（129）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse.

DOI：
10.3389/fcell.2018.00116
发表时间：
2018
期刊：
Frontiers in cell and developmental biology
影响因子：
5.5
作者：
Roy NH;Burkhardt JK
通讯作者：
Burkhardt JK

Analysis of glycogen metabolic pathway utilization by dendritic cells and T cells using custom phenotype metabolic assays.

使用定制表型代谢测定分析树突状细胞和 T 细胞对糖原代谢途径的利用。

DOI：
10.1016/j.jim.2018.04.006
发表时间：
2018
期刊：
Journal of immunological methods
影响因子：
2.2
作者：
Thwe,PhyuM;Amiel,Eyal
通讯作者：
Amiel,Eyal

The Duffy antigen receptor for chemokines regulates asthma pathophysiology.

趋化因子的达菲抗原受体调节哮喘病理生理学。

DOI：
10.1111/cea.12949
发表时间：
2017
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
0
作者：
Chapman,DG;Mougey,EB;VanderVelden,JL;Lahue,KG;Aliyeva,M;Daphtary,N;George,KL;Hoffman,SM;Schneider,RW;Tracy,RP;Worthen,GS;Poynter,ME;Peters,SP;Lima,JJ;Janssen-Heininger,YMW;Irvin,CG
通讯作者：
Irvin,CG

A kindred with mutant IKAROS and autoimmunity.

DOI：
10.1016/j.jaci.2018.04.008
发表时间：
2018-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
0
作者：
Van Nieuwenhove E;Garcia-Perez JE;Helsen C;Rodriguez PD;van Schouwenburg PA;Dooley J;Schlenner S;van der Burg M;Verhoeyen E;Gijsbers R;Frietze S;Schjerven H;Meyts I;Claessens F;Humblet-Baron S;Wouters C;Liston A
通讯作者：
Liston A

Immune Regulation in Pregnancy: A Matter of Perspective?