Vermont Center for Immunobiology/Infectious Diseases (VCIID)

佛蒙特州免疫生物学/传染病中心 (VCIID)

• 批准号: 10395160
• 负责人: Ralph C Budd
• 金额: $ 30.89万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395160
• 关键词: Address; Affect; Animal Model; Apoptosis; Apoptotic; Architecture; Atmosphere; Autoimmune; Autoimmune Diseases; Autoimmunity; Award; Basic Science; Biological; Biology; Bone Marrow; CNS autoimmune disease; Cell physiology; Cells; Centers of Research Excellence; Chimera organism; Chronic; Chronic Disease; Clinical assessments; Collaborations; Communicable Diseases; Core Facility; Coupled; Data; Demyelinating Diseases; Development; Discipline of obstetrics; Disease; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptors; Estrogens; Estrous Cycle; Excision; Experimental Autoimmune Encephalomyelitis; Faculty; Female; Flow Cytometry; Fostering; Functional disorder; Funding; Future; Gene Expression Profiling; Gene Targeting; Genetic; Goals; Gonadal Steroid Hormones; Gynecology; Immune; Immune response; Immune system; Immunobiology; Immunology; Incidence; Infection; Inflammation; Inflammatory; Investigation; Knockout Mice; Lead; Libido; Lupus; Mentors; Microglia; Mitogen-Activated Protein Kinases; Modeling; Molecular; Multiple Sclerosis; Mus; Myelogenous; Myeloid Cells; Neuraxis; Nuclear Receptors; Organ; Ovarian; Ovarian Follicle; Ovary; Parents; Pathogenesis; Pathology; Pathway interactions; Phagocytes; Phase; Phenotype; Physicians; Pilot Projects; Polycystic Ovary Syndrome; Positioning Attribute; Prevalence; Process; Publishing; Receptor Signaling; Regulation; Reproductive Physiology; Reproductive Sciences; Research; Research Personnel; Research Project Grants; Role; Scientist; Severity of illness; Sex Differences; Side; Signal Transduction; Strategic Planning; Talents; Testing; Time; Tissues; United States National Institutes of Health; Universities; Vermont; Woman; Women' s Health; cell type; conditional knockout; granulosa cell; immune function; in vitro Model; in vivo; insight; interdisciplinary collaboration; interest; macrophage; member; microbial; mouse model; multidisciplinary; primary ovarian insufficiency; ranpirnase; receptor; reproductive; reproductive function; reproductive hormone; reproductive organ; response; sex; tool

Abstract: scope of parent award and relevance to the NOSI on women's health The parent award, P30 GM118228, COBRE Phase III, supports the Vermont Center for Immunology and Infectious Diseases (VCIID) at the University of Vermont (UVM). The VCIID represents a multidisciplinary group of scientists and clinicians undertaking collaborative research in basic immunology, autoimmunity, microbial pathogenesis, and host response to infections. The keystone of the VCIID is scientific excellence through dedicated mentoring of talented junior faculty in an atmosphere that is both engaging and rigorous. In Phase III we seek to coalesce our mutual interests along research lines that will maintain our competitiveness and encourage basic, translational, and entrepreneurial research projects. We will foster this effort through the support of Pilot Project and Core Facilities, and administrative support. This Supplement Application represents a collaboration between two VCIID faculty members who are basic researchers, and two physician-scientists in the department of Department of Obstetrics, Gynecology and Reproductive Sciences. On both sides, there is a junior investigator paired with a senior investigator (respectively: Dr. Krementsov and Dr. Teuscher from VCIID; Dr. Brodeur and Dr. McGee from Ob-Gyn), which fits with VCIID's goal of support for junior faculty, as well as cross-departmental and interdisciplinary collaboration. The scientific goals of this Supplement Application are to investigate the mechanisms regulating innate immune cell functionality in the context of autoimmune disease and normal reproductive function. As such, this fits well within the scope of the VCIID, which supports basic immunology and autoimmunity research. With regard to relevance to women's health, in this supplement application, we propose a basic science approach to dissect molecular mechanisms whereby female reproductive hormones regulate immune cell function in the context of: 1) an autoimmune disease (MS, with highly biased incidence in females), and 2) female reproductive organ function. The NOSI states that the “proposed research must address at least one of the strategic goals of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research”. Our proposed research will address Strategic Objectives 1.1 (basic biology of sex differences), 1.2 (influence of sex on disease), and 1.5 (research on female reproductive function).

摘要：父母奖的范围以及与NOSI有关妇女健康的相关性 家长奖P30 GM118228，COBRE第三阶段，支持佛蒙特州免疫学中心和 佛蒙特大学（UVM）的传染病（VCIID）。 VCIID代表一个多学科组 科学家和临床医生进行了基本免疫学，自身免疫，微生物的合作研究 发病机理和宿主对感染的反应。 VCIID的基石是科学卓越的。 在既吸引人又严格的氛围中，才有才华横溢的初级教师的敬业精神。在第三阶段 我们寻求将我们的共同利益融合在研究线上，以维持我们的竞争力和 鼓励基本，翻译和企业家研究项目。我们将通过 支持试点项目和核心设施以及行政支持。 该补充申请代表了两个基本的VCIID教师之间的合作 研究人员以及妇产科和妇产部和 生殖科学。双方都有一个初级调查员与高级调查员配对 （分别：VCIID的Krementov博士和Teuscher博士； Brodeur博士和Ob-Gyn的McGee博士） 符合VCIID支持初级教师的目标，以及跨部门和跨学科的目标 合作。该补充应用的科学目标是调查调节的机制 自身免疫性疾病和正常生殖功能的背景下，先天免疫细胞功能。像这样， 这非常适合VCIID的范围，该VCIID支持基本的免疫学和自身免疫研究。 关于与妇女健康的相关性，在此补充申请中，我们提出了一项基础科学 剖析分子机制的方法，使女性复制激素调节免疫细胞 在以下情况下的功能：1）自身免疫性疾病（MS，在女性中高度偏见），2）女性 生殖器官功能。 NOSI指出，“拟议的研究必须至少解决 2019 - 2023年妇女健康研究的Trans-NIH战略计划的战略目标”。我们的建议 研究将解决战略目标1.1（性别差异的基本生物学），1.2（性别对 疾病）和1.5（关于女性生殖功能的研究）。

项目成果

The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse.

• DOI: 10.3389/fcell.2018.00116
• 发表时间: 2018
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Roy NH;Burkhardt JK
• 通讯作者: Burkhardt JK

Immune Regulation in Pregnancy: A Matter of Perspective?

• DOI: 10.1016/j.ogc.2016.07.004
• 发表时间: 2016-12
• 期刊: Obstetrics and gynecology clinics of North America
• 影响因子: 3.2
• 作者: Bonney EA

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

• DOI: 10.1126/science.abg5827
• 发表时间: 2021-08-20
• 期刊: Science (New York, N.Y.)
• 作者: Drayman N;DeMarco JK;Jones KA;Azizi SA;Froggatt HM;Tan K;Maltseva NI;Chen S;Nicolaescu V;Dvorkin S;Furlong K;Kathayat RS;Firpo MR;Mastrodomenico V;Bruce EA;Schmidt MM;Jedrzejczak R;Muñoz-Alía MÁ;Schuster B;Nair V;Han KY;O'Brien A;Tomatsidou A;Meyer B;Vignuzzi M;Missiakas D;Botten JW;Brooke CB;Lee H;Baker SC;Mounce BC;Heaton NS;Severson WE;Palmer KE;Dickinson BC;Joachimiak A;Randall G;Tay S
• 通讯作者: Tay S

A kindred with mutant IKAROS and autoimmunity.

• DOI: 10.1016/j.jaci.2018.04.008
• 发表时间: 2018-08
• 期刊: The Journal of allergy and clinical immunology
• 作者: Van Nieuwenhove E;Garcia-Perez JE;Helsen C;Rodriguez PD;van Schouwenburg PA;Dooley J;Schlenner S;van der Burg M;Verhoeyen E;Gijsbers R;Frietze S;Schjerven H;Meyts I;Claessens F;Humblet-Baron S;Wouters C;Liston A
• 通讯作者: Liston A

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

• DOI: 10.1016/j.mam.2018.08.001
• 发表时间: 2018-10
• 期刊: Molecular aspects of medicine
• 影响因子: 10.6
• 作者: van der Vliet A;Janssen-Heininger YMW;Anathy V
• 通讯作者: Anathy V