COBRE Center on Opioids and Overdose

COBRE 阿片类药物和药物过量中心

• 批准号: 10006576
• 负责人: JOSIAH D RICH
• 金额: $ 237.67万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006576
• 关键词: Accidental Injury; Acute; Address; Affect; Analgesics; Area; Benefits and Risks; Caring; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Clinical Research; Collaborations; Consultations; Country; Data; Data Management Resources; Discipline; Disease; Doctor of Philosophy; Education and Outreach; Ensure; Epidemic; Ethics; Faculty; Fentanyl; Fetus; Funding; Goals; Health Technology; Heroin; Hospitals; Imprisonment; Individual; Infrastructure; Institution; Joints; Knowledge; Leadership; Link; Mentors; Mentorship; Methodology; Motivation; Musculoskeletal Pain; Neonatal Abstinence Syndrome; Opiate Addiction; Opioid; Overdose; Pattern; Pharmaceutical Preparations; Policies; Population; Prevention; Prevention approach; Public Health; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Scientist; Senior Scientist; Services; Strategic Planning; Surgeon; Translational Research; United States; United States National Institutes of Health; Vehicle crash; Vulnerable Populations; Work; career; career development; cohort; contingency management; data visualization; early-career faculty; effective intervention; high risk population; implementation science; innovation; mHealth; member; multidisciplinary; named group; opioid misuse; opioid overdose; opioid use disorder; organizational structure; prescription opioid; prevent; programs; recruit; support tools

PROJECT SUMMARY We propose to build and sustain the Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use disorder and a need for more effective interventions to treat and prevent opioid misuse and overdose. We will approach these challenges through ongoing, cooperative partnership among senior scientists and early career investigators across several complementary disciplines. We propose a unique and innovative mentoring strategy that, in addition to primary project advising, will provide junior faculty members with specialized mentorship and services that empowers investigators to influence policy and practice through their research. Moreover, we will build four interdisciplinary cores that will provide infrastructure, consultation, and additional support services to ensure the successful career development of our Project Leaders. The long-term goal of the Center is to develop and sustain a critical mass of investigators specializing in opioids and overdose that benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this proposal is to establish and build the COBRE Center and to support the research activities of junior Project Leaders to ensure their transition to R01-funded scientists. There are two Specific Aims—one related to the establishment of a new disease-specific research center, and one encompassing four Research Projects that are linked by the themes of opioids and overdose. Aim 1: Establish the cores needed to develop and sustain a thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will be created to achieve this aim: an Administrative Core, a Data and Research Methods (DRM) Core, a Translational and Transformative (T2) Core, and a Special Populations (SP) Core. Aim 2: Support the selection, mentorship, and career development of early career faculty Project Leaders. The four initial research projects are: Project 1: (Beaudoin) “Informed opioid prescribing for acute musculoskeletal pain after motor vehicle collision: A support tool for assessing risks and benefits of analgesic medications before prescribing (STAAMP),” Project 2: (Claborn) “Prevention of Opioid Overdose following Incarceration: Leveraging Mobile Health Technology,” Project 3: (Becker) “Contingency Management in Combination with MAT for Opioid Use Disorders,” and Project 4: (Czynski) “Neonatal Abstinence Syndrome (NAS): Fetus to First Years.” The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance.

项目摘要 我们建议在阿片类药物和 在罗德岛医院和会员研究机构中用药过量。这项努力的动力在于 对对OID脆弱性的机制进行更深入的科学理解的巨大需求 使用障碍并需要更有效的干预措施来治疗和防止阿片类药物滥用和过量。我们 将通过高级科学家和早期的持续合作伙伴关系来应对这些挑战 职业调查员跨越了几个完整的学科。我们提出了一种独特而创新的心理 除主要项目咨询外，还将为初级教师提供专业的策略 能力和服务能够通过研究来影响政策和实践。 此外，我们将建造四个跨学科核心，这些核心将提供基础架构，咨询和其他 支持服务以确保我们项目领导者的成功职业发展。长期目标 该中心将开发和维持大量的研究人员，专门从事阿片类药物和过量服用 利益受影响的人群，并增强了会员调查员的竞争力。这个目的 提案是建立和建立鞋垫中心并支持初级项目的研究活动 领导者确保他们过渡到R01资助的科学家。有两个具体的目标 - 与 建立一个新的特定疾病研究中心，以及一个涵盖四个研究项目 由阿片类药物和过量的主题联系在一起。目标1：建立开发和维持所需的核心 主题多学科的阿片类药物和过量研究中心。将创建四个核心 实现此目的：行政核心，数据和研究方法（DRM）核心，转化和 变革性（T2）核心和特殊种群（SP）核心。目标2：支持选择，精神训练和 早期职业教师项目领导者的职业发展。最初的四个研究项目是：项目1： （beaudoin）“急性肌肉骨骼疼痛的阿片类药物处方后，机动车碰撞：支持 在开处方之前评估镇痛药的风险和益处的工具（Staamp）”，项目2： （Claborn）“监禁后预防阿片类药物过量：利用移动卫生技术”， 项目3 ：（贝克尔）“与阿片类药物使用障碍的垫子结合使用的应急管理”和 项目4：（czynski）“新生儿禁欲综合征（NAS）：胎儿至第一年。”拟议的中心将 将一个有前途的高级科学家，有前途的初级调查人员组成的跨学科小组， 杰出的顾问和合作者紧密合作，在一个领域建立卓越的中心 公共健康重要性至关重要的临床研究。