COBRE Center on Opioids and Overdose

COBRE 阿片类药物和药物过量中心

• 批准号: 10711725
• 负责人: JOSIAH D RICH
• 金额: $ 249.86万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711725
• 关键词: Accidental Injury; Address; Affect; Area; Award; COVID-19 pandemic; Caring; Centers of Research Excellence; Cessation of life; Clinical Research; Collaborations; Consultations; Country; Data; Data Management Resources; Dedications; Discipline; Disease; Doctor of Philosophy; Education and Outreach; Ensure; Ethics; Faculty; Funding; Goals; Hospitals; Individual; Infrastructure; Institution; Investments; Joints; Knowledge; Lead; Leadership; Link; Mentors; Mentorship; Methodology; Motivation; Opioid; Overdose; Pattern; Peer Review; Phase; Pilot Projects; Placebos; Policies; Population; Prevention approach; Public Health; Publications; Research; Research Activity; Research Design; Research Infrastructure; Research Methodology; Research Peer Review; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Scientist; Senior Scientist; Services; Strategic Planning; Translational Research; Underserved Population; United States; United States National Institutes of Health; Vehicle crash; Vulnerable Populations; Work; career; career development; chronic pain patient; community engaged research; community reintegration; data visualization; early-career faculty; effective intervention; empowerment; fentanyl use; heroin use; high risk population; implementation science; improved; innovation; member; multidisciplinary; open label; opioid misuse; opioid overdose; opioid use; opioid use disorder; organizational structure; prescription opioid; prevent; programs; recruit

Project Summary/Abstract We propose to further strengthen and sustain the successful Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the ongoing tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use and overdose and a need for more effective interventions to treat and prevent opioid misuse and overdose. We will approach these challenges through ongoing, cooperative partnership among senior scientists and early career investigators across several complementary disciplines. We will continue our unique and innovative mentoring strategy that, in addition to primary project advising, provides junior faculty members with specialized mentorship and services that empowers investigators to influence policy and practice through their research. Moreover, our four interdisciplinary cores provide infrastructure, consultation, and additional support services to ensure the successful career development of our Project Leaders. The long-term goal of the Center is to strengthen and sustain a critical mass of investigators specializing in opioids and overdose that benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this proposal is to strengthen and continue to develop the COBRE Center and to support the research activities of junior Project Leaders to ensure their transition to R01-funded scientists and enhance the critical mass of researchers. There are two Specific Aims—one related to the strengthening of our disease-specific research center, and one encompassing three Research Projects that are linked by the themes of opioids and overdose. Aim 1: Strengthen the cores needed to further develop and sustain our thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will continue to strive to achieve this aim: our Administrative Core, Data and Research Methods Core, Translational and Transformative Core, and Community Engaged Research Core. Aim 2: Support the selection, mentorship, and career development of early career faculty Project Leaders. The three initial research projects are: Project 1: Nicole Weiss, PhD - Prediction of Return to Opioid Use During Immediate Community Reintegration, Project 2: Michael Bernstein, PhD- Optimizing Open Label Placebos for Chronic Pain Patients, and Project 3: new RPL to be assigned; R01 notice of award was received, effective 9/30/22, for originally planned researcher. The Center brings together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work collectively to strengthen our center of excellence in an area of clinical research that is of critical public health importance.

项目摘要/摘要 我们建议进一步加强和维持成功的生物医学研究中心 罗德岛医院和会员研究机构的阿片类药物和过量用药。这 这项努力的动机在于持续不断地需要对 基于OID使用和过量的脆弱性的机制以及需要更有效的干预措施 治疗和防止阿片类药物滥用和过量。我们将通过持续的挑战来应对这些挑战 高级科学家和早期职业调查员之间的合作伙伴关系 学科。我们将继续我们独特而创新的心理策略，除了主要项目外 咨询公司，为初级教职员工提供专业的精通和服务 通过研究来影响政策和实践的研究人员。而且，我们的四个跨学科核心 提供基础设施，咨询和其他支持服务，以确保成功的职业 我们的项目负责人的发展。该中心的长期目标是加强和维持关键 大量的研究人员专门从事阿片类药物和过量的研究，使受影响的人群受益并增强 会员调查员的竞争力。该提议的目的是加强并继续 开发毛bre中心并支持初级项目领导者的研究活动，以确保他们的 过渡到R01资助的科学家并增强了研究人员的关键质量。有两个特定的 目的 - 与加强我们疾病特异性研究中心有关的目标，一个涵盖了三个 由阿片类药物和过量的主题联系起来的研究项目。目标1：加强核心 需要进一步发展和维持我们主题的多学科研究中心卓越研究中心 opioid和用药过量。四个核心将继续努力实现这一目标：我们的行政核心，数据 以及研究方法核心，转化和变革性核心以及社区参与研究 核。 AIM 2：支持早期职业教师项目的选择，指导和职业发展 领导者。最初的三个研究项目是：项目1：妮可·魏斯（Nicole Weiss），博士学位 - 返回阿片类药物的预测 在直接社区重新融合期间使用，项目2：迈克尔·伯恩斯坦（Michael Bernstein），博士优化开放标签 慢性疼痛患者的安慰剂和项目3：要分配的新RPL； R01奖励通知是 最初计划的研究人员收到了9/30/22的9/30。中心汇集了一个跨学科的 成熟的高级科学家，有前途的初级调查员和杰出顾问和 合作者共同努力，以加强我们在临床研究领域的卓越中心 关键的公共健康重要性。

项目成果

Racial and ethnic differences in emotion regulation: A systematic review.

• DOI: 10.1002/jclp.23284
• 发表时间: 2022-05
• 期刊: JOURNAL OF CLINICAL PSYCHOLOGY
• 影响因子: 3
• 作者: Weiss, Nicole H.;Thomas, Emmanuel D.;Schick, Melissa R.;Reyes, Miranda E.;Contractor, Ateka A.
• 通讯作者: Contractor, Ateka A.

Experimental Investigation of the Influence of Positive Emotion Dysregulation on Risky Behavior Following Idiographic Emotion Inductions.

• DOI: 10.1177/21677026221133295
• 发表时间: 2023-05
• 期刊: CLINICAL PSYCHOLOGICAL SCIENCE
• 影响因子: 4.8
• 作者: Weiss, Nicole H.;Schick, Melissa R.;Raudales, Alexa M.;Forkus, Shannon R.;Thomas, Emmanuel D.;Contractor, Ateka A.;Sullivan, Tami P.
• 通讯作者: Sullivan, Tami P.

Understanding how primary care providers report discussing substance use with transgender and gender diverse patients.

了解初级保健提供者如何报告与跨性别和性别多样化患者讨论药物使用问题。

• DOI: 10.1016/j.pec.2023.108101
• 发表时间: 2024
• 期刊: Patient education and counseling
• 影响因子: 3.5
• 作者: Wolfe,HillL;Fix,GemmaeM;Hughto,JaclynMW;Hughes,LandonD;Operario,Don;Hadland,ScottE;Siegel,Jennifer;Drainoni,Mari-Lynn
• 通讯作者: Drainoni,Mari-Lynn

Overdosing in a Motor Vehicle: Examination of Human, Geographic, and Environmental Factors.

机动车用药过量：人文、地理和环境因素的检查。

• DOI: 10.1097/nnr.0000000000000716
• 发表时间: 2024
• 期刊: Nursing research
• 影响因子: 2.5
• 作者: Lopez,DahiannaS;Parent,Jason;Stegnicki,Thomas;Kenyon,Zachariah;Arcoleo,Kimberly;Malloy,LiamC;Mello,MichaelJ
• 通讯作者: Mello,MichaelJ

Examining relations of polytraumatization typologies with positive memory count and phenomenology.

• DOI: 10.1080/10615806.2020.1795644
• 发表时间: 2021-01
• 期刊: Anxiety, stress, and coping
• 作者: Contractor AA;Kearns NT;Weiss NH;Blumenthal H
• 通讯作者: Blumenthal H