ShEEP Request for Sensorimotor Dynamic Response Measurement System

ShEEP 请求感觉运动动态响应测量系统

• 批准号: 10741038
• 负责人: Joseph Edward Barton
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10741038
• 关键词: Accidental Injury; Address; Affect; Afferent Neurons; Age; Age Years; Aging; Brain; Cessation of life; Clinical; Communication; Computer software; Computers; Deterioration; Diagnosis; Disease; Elderly; Elements; Equilibrium; Equipment; Evaluation; Feedback; Government; Hand; High Prevalence; Human; Individual; Injury; Measurement; Measures; Modality; Modeling; Morbidity - disease rate; Motion; Motor; Motor Cortex; Muscle; Musculoskeletal; Noise; Pathway interactions; Performance; Phase; Physiological; Population; Prevalence; Price; Process; Proprioception; Research; Sensory; Sheep; Signal Transduction; Source; Speed; Stimulus; System; Systems Integration; Tactile; Testing; Therapeutic Intervention; Time; Touch sensation; Transcranial magnetic stimulation; Veterans; Vision; Visual; Walking; accurate diagnosis; balance testing; cost effectiveness; data acquisition; disability; fall injury; falls; instrumentation; military veteran; motor control; neural; neurotransmission; pressure; prevent; response; sensory system; signal processing; transmission process; vibrotactile stimulation; virtual reality system; wireless

Falls are by far the leading cause of accidental injury and death in older adults. The Veteran population is more severely affected by falls since it is significantly older than the overall population (45% over 65 years of age vs. 13%); and Veterans would benefit substantially more from an accurate diagnosis and treatment of balance deficits and fall propensity. Despite its importance, much is still unknown about the manner in which balance control is compromised by age and disease. This is a proposal to acquire a Sensorimotor Dynamic Response Measurement System (SDRMS) from Government Scientific Source, Inc. to measure signal processing delays, transmission delays, and the neural noise associated with the four feedback sensorimotor pathways involved in standing and walking balance, the resulting feedforward motor signals to the musculature, and the response dynamics of the associated musculature. Human balance is controlled and maintained by numerous interacting sensorimotor and musculoskeletal elements, organized into an adaptive feedback control loop. These elements communicate with one another via neural signals, and the quality of these signals constitutes an important, largely overlooked aspect of this loop’s performance. Aging, associated morbidities, and injuries not only cause the elements within this loop to deteriorate; they also increase the delays and noise associated with their neural signals. Increased transmission delays and noise will in themselves degrade balance system performance and can cause such a system to fail if they become excessive. Despite its significance, balance-related transmission delays and noise have rarely been measured and investigated in a comprehensive and systematic manner. The SDRMS addresses this gap. This information is valuable for studying vulnerable Veteran populations in that it provides quantitative measures of an individual’s balance capability. Proper assessment of the sensory function in balance requires that each modality be isolated from the others and tested independently (to prevent the confounding effects of sensory system redundancy) to determine the accuracy and sensitivity with which it detects its associated stimulus; the speed with which its signals reach the higher level processing centers of the brain, and the noise associated with its signal. The SDRMS then measures the speed with which the motor centers of the brain communicate muscle activation commands to the musculature, the noise associated with these signals, and the muscles’ resulting activation dynamic response. These measures can be compared with those of young healthy individuals with no deficits to quantify the degree of deterioration brought on by age, disease, and injury; and to track changes in balance capability over time. The system can also identify the relative contribution of specific balance system elements and the neural signals they transmit to this deterioration. Government Scientific Source, Inc. will deliver the integrated system. Assessment by the SDRMS occurs in five phases corresponding to each of its five modules. Though the modules are employed in sequence, they share individual components. Thus, it would not be possible to “break the system apart” and employ the modules as separate measurement systems. Moreover, though the individual sensory modalities and feedforward pathways are tested in isolation from one another, it is important that all the assessments be conducted contiguously, as the balance system can adapt and change in subtle ways over time.

到目前为止，跌倒是造成意外伤害和老年人死亡的主要原因。退伍军人人口 由于跌倒的影响更大，因此更严重地影响了整体人口（在65年内45％ 年龄和13％）；从准确的诊断和处理中，退伍军人将大大受益 平衡定义和跌倒承诺。尽管它的重要性，但仍然不知道 平衡控制受年龄和疾病损害。这是获得感觉运动动态的建议 政府科学资源公司的响应测量系统（SDRMS）来衡量信号 处理延迟，传输延迟以及与四个反馈感觉运动相关的神经噪声 涉及站立和步行平衡的途径，由此产生的前馈电机信号 肌肉和相关肌肉的反应动力学。 人类平衡受到许多相互作用的感觉运动和维护 肌肉骨骼元素，组织成自适应反馈控制环。这些元素交流 通过神经信号彼此，这些信号的质量构成了重要的，很大程度上是 忽略了该循环的性能的方面。衰老，相关的病毒和伤害不仅导致 该循环中的要素以确定；他们还增加了与中立相关的延误和噪音 信号。增加传输延迟和噪音本身会降低平衡系统的性能 如果这种系统变得过大，可能会导致这种系统失败。尽管具有重要意义，但与平衡有关 传输延迟和噪声很少在全面的和调查 系统的方式。 SDRMS解决了此差距。此信息对于研究脆弱而有价值 退伍军人人口提供了对个人平衡能力的定量度量。恰当的 平衡的感觉函数的评估要求将每种方式与其他方式隔离，并且 独立测试（以防止感觉系统冗余的混杂作用）确定 检测其相关刺激的准确性和灵敏度；信号达到的速度 大脑的较高水平处理中心及其信号相关的噪声。然后是SDRM 测量大脑运动中心传达肌肉激活命令的速度 肌肉组织，与这些信号相关的噪声以及肌肉的激活动态 回复。可以将这些措施与没有缺陷的年轻健康个体的措施进行比较 量化按年龄，疾病和伤害提出的定义程度；并跟踪平衡的变化 随着时间的推移能力。该系统还可以确定特定平衡系统的相对贡献 它们传递到此定义的元素和神经信号。 政府科学资料来源公司将交付集成系统。 SDRM评估 发生在与其五个模块中的每个模块相对应的五个阶段。虽然模块已在 序列，它们共享单个组件。那是不可能“拆分系统”，并且 员工将模块作为单独的测量系统。而且，尽管单个感官方式 和前馈途径是彼此隔离的，所有评估都必须 进行连续进行，因为余额系统可以随着时间的流逝而以微妙的方式适应和变化。