Examining domains of trauma response and their link to chronic pain

检查创伤反应的领域及其与慢性疼痛的联系

• 批准号: 10698022
• 负责人: Jennifer Pierce
• 金额: $ 13.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10698022
• 关键词: Accident and Emergency department; Accidental Injury; Acute; Address; Affect; Affective; American; Area; Award; Characteristics; Computers; Data; Data Analyses; Data Set; Dedications; Development; Distress; Early identification; Emergency department visit; Emotional; Emotions; Environment; Evaluation; Funding; Future; Goals; Health; Intentional injury; Knowledge; Leadership; Link; Longitudinal Studies; Measures; Mediator; Mentored Research Scientist Development Award; Mentorship; Methodology; Methods; Michigan; Modeling; National Institute of Mental Health; Neurobiology; Outcome; Pain; Participant; Patient Self-Report; Patients; Perception; Phenotype; Post-Traumatic Stress Disorders; Psychophysics; Reaction; Recording of previous events; Recovery; Reporting; Research; Research Design; Research Domain Criteria; Research Personnel; Research Proposals; Risk; Risk Factors; Role; Sensory; Series; Social Perception; Social Processes; Statistical Data Interpretation; Stimulus; Surveys; Survivors; Symptoms; Testing; Time; Training; Trauma; Universities; Vehicle crash; Vulnerable Populations; chronic pain; clinical pain; cohort; emotional trauma; experience; experimental study; falls; individualized medicine; lens; pain chronification; pain outcome; pain sensitivity; pain symptom; prevent; programs; psychologic; psychological symptom; response; sexual assault; skill acquisition; skills; social; trauma exposure; trauma symptom; traumatic event

PROJECT SUMMARY/ABSTRACT Physical and emotional trauma are linked to numerous negative health effects, including a nearly three-fold increase in the odds of reporting chronic pain. Research suggests that post-traumatic chronic pain is preceded by at least three classes of factors (i.e., psychological, neurobiological, and social) that might allow for earlier identification of vulnerable individuals. Yet, current data used to elucidate potential mechanisms linking traumatic events to pain development have been limited. Capturing longitudinal data that identifies early risk factors and vulnerabilities to pain is particularly difficult. Additionally, few studies have evaluated the role of social perception and sensitivity to negative social stimuli (i.e., ‘social sensitivity’) as potential mediators linking trauma exposure to physical pain. The current proposal seeks to address these limitations by integrating multiple domains and levels of analysis to examine the impact of traumatic response on the development and persistence of chronic pain. The project will first leverage existing longitudinal and experimental data collected as part of the Advancing Understanding of RecOvery afteR traumA (AURORA) study (NIMH U01MH110925) to explore psychological and neurobiological contributions to post-traumatic pain vulnerability. The project will then expand beyond the data available in AURORA by conducting an experimental study in participants with varying histories of trauma and clinical pain characteristics to examine the associations between social perception and sensitivity, trauma sequelae, and pain. The study will utilize experimental paradigms measuring emotion perception, perspective-taking, and social sensitivity and assess these social processing factors as potential mediators of the association between trauma sequelae and pain characteristics. The association between survey measures of social perception and pain symptoms will also be assessed over time. This research proposal is part of a larger training plan that allows the candidate to develop expertise in trauma and pain, longitudinal data analysis, and experimental methodology; and leadership skills through management of a small study team. The candidate has assembled a mentorship team of experts with extensive expertise in pain phenotyping, trauma, experimental methodology, and statistical analysis. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on the intersection of trauma and pain. It will also provide critical preliminary data for future funding dedicated to advancing our understanding in this critical area of research.

项目摘要/摘要 身体和情感创伤与许多负面健康影响有关，包括近三倍 报告慢性疼痛的几率增加。研究表明，创伤后的慢性疼痛先于 至少有三类因素（即心理学，神经生物学和社会）可能允许更早 识别脆弱的人。然而，当前数据用于阐明潜在机制连接 疼痛发育的创伤事件受到限制。捕获确定早期风险的纵向数据 因素和痛苦脆弱性特别困难。此外，很少有研究评估 社会感知和对负面社会刺激的敏感性（即“社会敏感性”）作为潜在的调解人 创伤暴露于身体疼痛。当前的建议旨在通过整合来解决这些限制 多个领域和分析水平，以检查创伤反应对发展的影响 慢性疼痛的持久性。该项目将首先利用收集的现有纵向和实验数据 作为对恢复后创伤（Aurora）研究（NIMH U01MH110925）的进步的一部分 探索对创伤后疼痛脆弱性的心理和神经生物学贡献。该项目将 然后通过对参与者进行实验研究，超越了Aurora中可用的数据 创伤和临床疼痛特征的不同历史，以检查社会之间的关联 感知和敏感性，后遗症和疼痛。该研究将利用实验范例 衡量情绪感知，观点的观点以及社会敏感性和评估这些社会处理 因素是后遗症与疼痛特征之间关联的潜在介体。这 社会感知和疼痛症状的调查措施之间的关联也将进行评估 时间。该研究建议是一项更大的培训计划的一部分，该计划使候选人可以发展专业知识 创伤和疼痛，纵向数据分析和实验方法；和领导能力通过 小型学习团队的管理。候选人已与 疼痛表型，创伤，实验方法和统计分析方面的广泛专业知识。 结合密歇根大学丰富的环境，该奖项将为专注的培训提供 建立一个独特的专业知识和独立研究计划，重点是 创伤和痛苦。它还将为未来的资金提供关键的初步数据，致力于推进我们的 在这一关键领域的理解。