Pilot Innovation Core

试点创新核心

基本信息

批准号：
10023723
负责人：
STEVEN M KOGAN
金额：
$ 11.86万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10023723
关键词：
Addictive Behavior Address Adolescence Adolescent Affect African American Age Alcohol or Other Drugs use Applications Grants Area Attenuated Award Behavioral Biological Process Brain Cancer Grant Supplements (P30)Centers of Research Excellence Childhood Chronic stress Communities Data Data Analyses Data Set Development Diet Habits Disease Drug usage Eating Etiology Exposure to Family Feedback Fostering Foundations Functional Magnetic Resonance Imaging Funding Funding Mechanisms Future Generations Goals Grant Health Immune Immunology Individual Inflammation Inflammation Mediators Investigation Mediator of activation protein Mentors Mentorship Methodology Minority Modeling Monitor Neurobiology Neuroimmune Neurosciences Observational Study Peer Review Pilot Projects Plant Roots Population Poverty Prevention Prevention program Prevention trial Preventive Process Publications Randomized Recording of previous events Research Research Personnel Research Training Resources Risk Role Sample Size Science Scientific Advances and Accomplishments Scientist Seeds System Training Underrepresented Groups Universities Work age group cardiometabolism career career development cohort contextual factors design drug abuse prevention drug development experience faculty mentor innovation insight interdisciplinary collaboration network models next generation novel novel strategies pedagogy programs psychosocial racial discrimination randomized trial ranpirnase recruit relating to nervous system research study resilience secondary analysis social substance use prevention success training project transmission process working group young adult

Addictive Behavior Address Adolescence Adolescent Affect African American Age Alcohol or Other Drugs use Applications Grants Area Attenuated Award Behavioral Biological Process Brain Cancer Grant Supplements (P30)Centers of Research Excellence Childhood Chronic stress Communities Data Data Analyses Data Set Development Diet Habits Disease Drug usage Eating Etiology Exposure to Family Feedback Fostering Foundations Functional Magnetic Resonance Imaging Funding Funding Mechanisms Future Generations Goals Grant Health Immune Immunology Individual Inflammation Inflammation Mediators Investigation Mediator of activation protein Mentors Mentorship Methodology Minority Modeling Monitor Neurobiology Neuroimmune Neurosciences Observational Study Peer Review Pilot Projects Plant Roots Population Poverty Prevention Prevention program Prevention trial Preventive Process Publications Randomized Recording of previous events Research Research Personnel Research Training Resources Risk Role Sample Size Science Scientific Advances and Accomplishments Scientist Seeds System Training Underrepresented Groups Universities Work age group cardiometabolism career career development cohort contextual factors design drug abuse prevention drug development experience faculty mentor innovation insight interdisciplinary collaboration network models next generation novel novel strategies pedagogy programs psychosocial racial discrimination randomized trial ranpirnase recruit relating to nervous system research study resilience secondary analysis social substance use prevention success training project transmission process working group young adult

展开

项目摘要

PROJECT SUMMARY: Pilot Core The Pilot Core of the proposed P50 supports the vitality of the Center by facilitating investigator development and promoting new research insights and priorities for the Center’s research studies. This program will provide a funding mechanism for pilot project applications from early career investigators (ECIs) and from established investigators seeking to extend their research into assessment of neural and inflammatory mediators of drug use and cardiometabolic health. Investigators can access seed grant funding and Center resources to (a) assess the feasibility of exploring a new research question, (b) apply a new approach, or (c) use existing methodology to explore a novel way to advance a new area of scientific exploration. The seed grant program also will provide resources to support secondary data analysis of CTAPS datasets from concluded and ongoing projects. These datasets were collected through both longitudinal, observational research and randomized prevention trials. Our datasets will permit replication of findings, comparison of models for different age groups (e.g., adolescents versus young adults), and aggregation of variables across data sets (harmonization) to maximize sample size or the age span to be evaluated. In addition to the investigator career development that occurs via seed grant funding, we propose to implement a targeted mentoring program for ECIs. Although not limited to minority or African American ECIs, an expressed goal of this program is to recruit early-career scientists from underrepresented backgrounds at UGA and our P50 partner, Northwestern University (NWU). This program is informed by CTAPS investigators’ experience with mentoring in the P30, a history of systematic mentoring for junior faculty, mentoring via diversity supplements, and implementing an Institutional Research Training Grant. To initiate the Year 1 (Y1) pilot project and mentoring system, we designed a unique pilot that will serve as a collaborative training experience for the Y1 mentoring cohort and advance the scientific aims of the Center. This experience centers around a secondary data analysis of fMRI, inflammation, and psychosocial data collected during the past CTAPS P30 grant period. The training cohort will work with this unique, rich data set under the guidance of Dr. Brody, the Center Director, with methodological and substantive support from P50 scientists and statisticians. The aims of our Pilot Core are to: (1) administer a seed grant program designed to support pilot projects that address African Americans’ drug use and cardiometabolic vulnerabilities; (2) provide targeted mentoring to early-career investigators, particularly those from underrepresented groups; and (3) implement a unique Year 1 pilot project/training experience: “Racial discrimination, protective processes, and drug use among African Americans: The role of NIN mechanisms.”

项目摘要：飞行员核心拟议的P50的试验核心通过支持研究者开发来支持该中心的活力并促进该中心研究的新研究见解和优先事项。该程序将提供早期职业调查人员（ECI）的试点项目应用的资金机制以及已建立的寻求将其研究扩展到对药物的神经和炎症介质评估的研究人员使用和心脏代谢健康。调查人员可以获取种子赠款资金和中心资源到（a）评估探索新研究问题的可行性，（b）采用新方法，或（c）使用现有探索一种新的方法来推进科学探索领域的新方法。种子赠款计划还将提供资源来支持从结论和正在进行的项目。这些数据集是通过纵向，观察性研究和随机预防试验。我们的数据集将允许复制调查结果，对不同的模型进行比较年龄组（例如，青少年与年轻人），以及跨数据集的变量聚集（统一）以最大化样本量或要评估的年龄跨度。除了调查员职业通过种子赠款资金发生的开发，我们建议实施针对性的心理计划尽管不仅限于少数民族或非裔美国人ECI，但该计划的明确目标是招募来自UGA代表不足的背景和我们的P50合作伙伴的早期职业科学家，西北大学（NWU）。 CTAPS调查人员在P30中的心理经验（A）初级教师的系统心理史，通过多样性补充进行心理和实施机构研究培训补助金。启动1年（Y1）试点项目和心理系统，我们设计了一个独特的飞行员推进该中心的科学目标。这种体验围绕fMRI的二级数据分析，在过去的CTAPS P30赠款期间收集的炎症和社会心理数据。培训队列将在中心主任布罗迪博士的指导下与这个独特，丰富的数据集合作，方法论以及P50科学家和统计学家的实质支持。我们的飞行员核心的目的是：（1）管理一项种子赠款计划，旨在支持针对非洲裔美国人使用毒品使用和的试点项目心脏代谢漏洞；（2）为早期研究人员提供了针对性的心理，特别是来自代表性不足的群体；（3）实施独特的1年试点项目/培训经验：“种族非裔美国人的歧视，保护过程和吸毒：NIN机制的作用。”