A Dual Inoculation Approach to Alcohol Prevention Among African American Youth

非裔美国青少年预防酒精双重接种方法

• 批准号: 8420012
• 负责人: STEVEN M KOGAN
• 金额: $ 66.82万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-10 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8420012
• 关键词: 11 year old; 14 year old; Accounting; Achievement; Address; Adolescence; Adolescent; Affect; African American; Age; Alcohol consumption; Attention; Behavior; Behavioral; Cessation of life; Childhood; Cognitive; Cost Effectiveness Analysis; Data; Development; Educational Curriculum; Evaluation; Event; Family; Family Research; Frequencies; Guidelines; Injury; Intervention; Investigation; Lead; Link; Longitudinal Studies; Medical; Modeling; Morbidity - disease rate; Outcome; Parents; Pattern; Prevention; Prevention program; Prevention strategy; Preventive; Preventive Intervention; Primary Prevention; Process; Public Health; Quality of life; Randomized; Recruitment Activity; Relative (related person); Research; Resources; Risk; Risk Factors; Rural; Sampling; School-Age Population; Scientist; Series; Specific qualifier value; Staging; Students; Teenagers; Testing; Thinking; Time; Translating; Vaccines; Work; Youth; alcohol prevention; alcohol related problem; alcohol use initiation; arm; base; binge drinking; cost; cost effectiveness; design; deter alcohol use; early adolescence; early alcohol use; four-arm study; high risk; high school; meetings; middle school; mortality; novel; preadolescence; prevent; programs; psychosocial; public health relevance; social; underage drinking

DESCRIPTION (provided by applicant): The personal and social consequences of underage drinking are extensive, ranging from injury to impaired psychosocial and cognitive development. This proposal addresses the need for a transformation in current thinking regarding the primary prevention of alcohol use among adolescents in general, and rural African American youth in particular. To date, the implementation and evaluation of alcohol use prevention has been limited by an exclusive focus on delivering efficacious interventions during the transition to earl adolescence. This paradigm is based on the assumption that a single inoculation of an efficacious preventive intervention prior to entering middle school is sufficient to deter alcohol use through the high school years. Inclusive reviews reveal, however, that primary prevention programs implemented in preadolescence fail to achieve robust, long-term results. These programs do not address the fact that many youth will begin using alcohol in high school, often rapidly escalating in their use. A preadolescent inoculation of prevention is not sufficient to equp youth for the novel risk processes they will encounter in high school. In contrast, we propose that achievement of public health impact requires a "dual-inoculation" prevention strategy, one that addresses the onset of use in both early adolescence and mid-adolescence and provides developmentally tailored curricula at each developmental stage. Based on longitudinal studies with rural African American families that documented the changing context of alcohol use risk and protective processes from late childhood through adolescence, scientists at the Center for Family Research developed a series of developmentally appropriate, family- centered preventive interventions that have proven efficacious in in preventing alcohol use: the SAAF program for youth age 10-12 and the SAAF-Teen program for youth age 14-16. These programs afford a unique opportunity to test dual-inoculation hypotheses. We propose to test the relative efficacy of a dual inoculation (SAAF + SAAF-Teen) versus a preadolescent inoculation (SAAF only), a mid-adolescent inoculation (SAAF- Teen only), or no inoculations (control) in a four-arm trial with 460 rural African American youth and their parents. This design permits the evaluation of the relative superiority of the dual inoculation as well as providing information about the mechanisms through which intervention-targeted protective processes affect alcohol use behavior. This study represents the first evaluation of a dual-inoculation strategy, one that has the potential to enhance significantly the practice of primary prevention. To further enhance the potential for widespread dissemination of the approach, we propose to conduct cost-effectiveness analysis alongside the prevention trial.

描述（由申请人提供）：未成年人饮酒的个人和社会后果广泛，从伤害到受损的社会心理和认知发展。该提议旨在解决当前思维中关于主要预防青少年饮酒，尤其是非裔美国人青年的最佳预防饮酒的必要性。迄今为止，预防饮酒的实施和评估受到专有的重点，专注于在过渡到伯爵青春期期间提供有效的干预措施。该范式是基于这样的假设：在进入中学之前，一次接种有效的预防性干预措施就足以阻止在高中期间的酒精使用。然而，包容性的评论表明，预防前实施的主要预防计划未能实现强大的长期结果。这些计划并没有解决许多年轻人将在高中开始使用酒精的事实，通常会迅速升级他们的使用。预防预防的预发不足以使年轻人在高中遇到的新风险过程中。相比之下，我们建议实现公共卫生影响需要“双重接种”预防策略，该策略旨在解决青春期早期和青春期早期使用的发作，并在每个发展阶段提供开发量身定制的课程。基于与非裔美国人家庭的纵向研究，记录了从童年后期到青春期的饮酒风险和保护过程的不断变化的背景，家庭研究中心的科学家开发了一系列适合发展的，以家庭为中心的预防干预措施，这些干预措施已证明有效地在预防酒精饮酒方案：预防10-12岁的SAAF计划和SAAF-TEEN年龄为10-12岁的SAAF-TEEN年龄和SAAF-TEEN年龄段的年龄14-16。这些程序为测试双接种假设提供了独特的机会。我们建议测试双重接种（SAAF + SAAF-TEEN）的相对疗效与预成次接种（仅SAAF）（仅SAAF），中期接种（仅SAAF-青少年），或在460个农村非洲非洲裔美国青年及其父母的四臂试验中未接种（仅SAAF-青少年）。该设计允许评估双重接种的相对优越性，并提供有关针对干预措施的保护过程影响酒精使用行为的机制的信息。这项研究代表了对双接种策略的首次评估，该策略有可能显着增强初级预防的实践。为了进一步提高该方法广泛传播的潜力，我们建议在预防试验中进行成本效益分析。