Multidisciplinary Studies of Hematopoietic Malignancies

造血系统恶性肿瘤的多学科研究

• 批准号: 10007423
• 负责人: Lindsay Morton
• 金额: $ 51.28万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10007423
• 关键词: AIDS/HIV problem; Autoimmune Diseases; Behavior; Behavioral; Case-Control Studies; Data; Environment; Environmental Risk Factor; Epidemiology; Etiology; General Population; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic study; Graft Rejection; HIV; HIV Seropositivity; Hematopoietic Neoplasms; Hepatitis C; Iatrogenesis; Immune; Immunosuppression; Individual; International; Journals; Lymphoma; Lymphomagenesis; Malignant Neoplasms; Medical; Medical History; Meta-Analysis; Methods; Non-Hodgkin' s Lymphoma; Organ Transplantation; Pathology; Pattern; Peer Review; Publishing; Reporting; Research; Risk; Solid; Source; Transplantation; Virus Diseases; Work; base; gene interaction; genome wide association study; high risk; immune function; immunosuppressed; improved; lifestyle factors; multidisciplinary; outcome forecast; prevent

Non-Hodgkin lymphoma (NHL) is the sixth most common malignancy in the US. By improving understanding of the causes of NHL in the general population, we will identify the individuals at highest risk of developing NHL as well as elucidate mechanisms of lymphomagenesis. Additionally, NHL is one of the most common malignancies occurring among immunosuppressed individuals, including those with HIV/AIDS and those receiving iatrogenic immunosuppression to prevent graft rejection following transplantation. Because individuals with HIV are living longer with improved immune function, this research will identify HIV-positive individuals who are at highest risk for developing NHL based on other etiologic factors.1. We completed analysis of the main case-control study and published approximately 80 reports in peer-reviewed journals. 2. To conduct a GWAS and to study genetic polymorphisms with more power, we are pooling data within the International Lymphoma Epidemiology Consortium (InterLymph). 3. We continued to collaborate with InterLymph on other analyses as well, including a broad range of environmental, medical history, and lifestyle factors.4. Through this collaborative research, we demonstrated that the patterns of risk vary according to the subtype of lymphoma. In particular, we showed that various immune-related medical conditions (e.g., autoimmune diseases, hepatitis C viral infection) are most closely associated with certain NHL subtypes. These subtypes are the same as those that are most strongly elevated among individuals with HIV/AIDS and following solid organ transplantation. 5. We combined environmental data from other sources with study data to continue to investigate environmental risks. This work is ongoing.

非霍奇金淋巴瘤 (NHL) 是美国第六大常见恶性肿瘤。通过加深对一般人群中 NHL 病因的了解，我们将确定罹患 NHL 风险最高的个体，并阐明淋巴瘤发生机制。此外，NHL 是免疫抑制个体中最常见的恶性肿瘤之一，包括艾滋病毒/艾滋病患者和接受医源性免疫抑制以防止移植后移植物排斥的患者。 由于 HIV 感染者的寿命更长且免疫功能得到改善，因此本研究将根据其他病因因素识别出发展 NHL 风险最高的 HIV 阳性个体。1。我们完成了主要病例对照研究的分析，并在同行评审期刊上发表了约 80 份报告。 2. 为了进行 GWAS 并更有效地研究遗传多态性，我们正在国际淋巴瘤流行病学联盟 (InterLymph) 内汇集数据。 3. 我们还继续与 InterLymph 合作进行其他分析，包括广泛的环境、病史和生活方式因素。4。通过这项合作研究，我们证明了风险模式根据淋巴瘤的亚型而变化。 特别是，我们发现各种与免疫相关的医疗状况（例如自身免疫性疾病、丙型肝炎病毒感染）与某些 NHL 亚型关系最为密切。这些亚型与艾滋病毒/艾滋病患者和实体器官移植后最强烈升高的亚型相同。 5. 我们将其他来源的环境数据与研究数据相结合，继续调查环境风险。这项工作正在进行中。