Multidisciplinary Studies of Hematopoietic Malignancies

造血系统恶性肿瘤的多学科研究

• 批准号: 8763627
• 负责人: Lindsay Morton
• 金额: $ 86.89万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763627
• 关键词: Behavior; Behavioral; Case-Control Studies; Data; Environmental Risk Factor; Etiology; Genetic Polymorphism; Genetic Predisposition to Disease; Hair Dyes; Hematopoietic Neoplasms; Hepatitis C virus; Journals; Lymphoma; Meta-Analysis; Methods; Overweight; Pathology; Pattern; Peer Review; Publishing; Reporting; Reproductive History; Risk; Source; Sunlight; Work; gene environment interaction; genetic risk factor; genome wide association study; improved; multidisciplinary; outcome forecast

1. We completed analysis of the main case-control study and published approximately 50 reports in peer-reviewed journals. 2. We demonstrated that the patterns of risk vary according to the subtype of lymphoma. 3. We showed that genetic risk factors for occurrance of NHL also predicted survival; We're continuing to explore other subtypes to compare the patterns of etiology and survival. 4. To conduct a GWAS and to study the genetic polymorphism with more power, we are pooling data within Interlymph. 5. We continued to collaborate with InterLymph and we reported on the pooled estimates for overweight, sunlight, hepatitis C virus, hair dyes, and reproductive history. 6. We combined environmental data from other sources with study data to continue to investigate environmental risks. This work is ongoing.

1. 我们完成了主要病例对照研究的分析，并在同行评审期刊上发表了约 50 份报告。 2. 我们证明，风险模式根据淋巴瘤亚型的不同而不同。 3.我们发现NHL发生的遗传危险因素也可以预测生存；我们正在继续探索其他亚型，以比较病因和生存模式。 4. 为了进行 GWAS 并更有效地研究遗传多态性，我们正在 Interlymph 中汇集数据。 5. 我们继续与 InterLymph 合作，报告了超重、阳光、丙型肝炎病毒、染发剂和生殖史的汇总估计值。 6. 我们将其他来源的环境数据与研究数据相结合，继续调查环境风险。这项工作正在进行中。