Longitudinal Dyadic Analysis of HIV-positive Substance Users with Trauma History

有创伤史的艾滋病毒阳性物质使用者的纵向二元分析

• 批准号: 8033452
• 负责人: Deborah Lynne Jones
• 金额: $ 8.05万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033452
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adult; Age; Alcohol or Other Drugs use; Autoimmune Diseases; Award; Behavior; Belief; Brain; Cardiovascular Diseases; Childhood; Cognitive; Collaborations; Competence; Complex; Couples; Data; Data Set; Development; Diabetes Mellitus; Equation; Ethnic Origin; Female; Frequencies; Gender; Goals; HIV; HIV Seropositivity; Health; Health behavior; Individual; Intervention; K-18 conjugate; K-Series Research Career Programs; Learning; Life; Linear Models; Malignant Neoplasms; Mediating; Mediator of activation protein; Mental Health; Mental disorders; Mentors; Meta-Analysis; Methods; Modeling; Neurosecretory Systems; Outcome; Outcome Study; Participant; Population; Post-Traumatic Stress Disorders; Pregnancy; Process; Public Health; Randomized; Recording of previous events; Relative (related person); Research; Research Personnel; Research Project Grants; Risk; Risk Behaviors; Risk Reduction; Role; Severities; Sex Orientation; Sexual Partners; Sexually Transmitted Diseases; Socioeconomic Status; Statistical Methods; Stress; Survivors; Symptoms; Techniques; Theoretical model; Time; Translational Research; Translations; Trauma; Victimization; Woman; behavioral/social science; career; experience; group intervention; immune function; member; men; pediatric trauma; post intervention; response; sex risk; sexual trauma; skills; standard of care; stressor; translational study

DESCRIPTION (provided by applicant): As a mid-career investigator in applied behavioral and social sciences related to HIV/AIDS, my goal in applying for a Short-term Mentored Career Development Award (K-18) is to learn to employ hierarchical linear modeling/structural equation modeling analytic strategies to more comprehensively address the complexity of the dyadic data sets generated by my collaborative research on HIV prevention with couples. These analytic skills would then enable me to assess the interactive effects of trauma, substance use, sexual partners and HIV on health behavior and health outcomes and apply those results at the individual, couple and population level. To meaningfully apply these data at the population level also require the ability to utilize and collaboratively develop statistical methods for translational studies and public health models. The research project, "Longitudinal Dyadic Analysis of HIV-positive Substance Users with a Trauma History" addresses the role of a potential third variable (substance use and sexual partners) on risk behavior outcomes in response to interventions among men and women as couples in which one member or both may be substance users and have a history of sexual trauma. This project seeks to clarify the relationship between the influence of sexual partners, substance use and sexual trauma on risk behaviors utilizing longitudinal dyadic analysis within the Actor Partner Interdependence Model framework (APIM). Specifically, I propose the following educational and research goals to: 1. Learn how to apply the APIM (theoretical model) for interpreting couples behavior and their response to interventions using the associated longitudinal dyadic statistical techniques (analytic component) to analyze existing data sets. Additionally, I propose to conduct analyses on a research project to using an existing R01: 2. Address the interactive effects of trauma, substance use, sexual partners and HIV on health behavior and health outcomes at the individual, couple and population level, utilizing longitudinal multiple groups the Actor Partner Interdependence Model framework (APIM) for indistinguishable dyads 3. Gain skills in the use and development of public health models and analytic strategies for translational studies. The APIM, which applies complex techniques of longitudinal structural equation modeling to the analysis of couple dyads in group formats, addressing the relative influences of partners and mediating factors on risk behaviors, will enable me to acquire the critical skills to interpret dyadic data and provide me with a bridge to develop dyadic translational research models and methods for couples interventions. Support through the K18 will provide protected time to gain competence in dyadic and public health statistical methods and models, while my research collaborations provide the remaining 50% time during the period of the award. PUBLIC HEALTH RELEVANCE: As a mid-career investigator in applied behavioral and social sciences related to HIV/AIDS, my goal in applying for a Short-term Mentored Career Development Award (K-18) is to learn to employ hierarchical linear modeling/structural equation modeling analytic strategies to more adequately address the complexity of the dyadic data sets generated by my research on HIV prevention with couples. These datasets address the interactive effects of trauma, substance use, sexual partners and HIV on health behavior and health outcomes at the individual, couple and population level.

描述（由申请人提供）：作为与艾滋病毒/艾滋病有关的应用行为和社会科学的中期研究者，我的目标是申请短期指导的职业发展奖（K-18）是要学会学会利用层次线性建模/结构方程式建模策略，以更全面地解决与二核数据的复杂性，该策略与我的二核数据集成了我的相关性。这些分析技能将使我能够评估创伤，药物使用，性伴侣和艾滋病毒对健康行为和健康结果的互动效果，并将这些结果应用于个人，夫妇和人口水平。为了有意义地在人群层面应用这些数据，还需要能够利用和协作开发转化研究和公共卫生模型的统计方法。该研究项目“具有创伤史的HIV阳性药物使用者对艾滋病毒阳性药物使用者的纵向二分析”介绍了潜在的第三个变量（药物使用和性伴侣）对响应男性和女性的干预措施的风险行为结果的作用，其中一个成员或两者都可能是毒品使用者，并且具有性创伤历史。该项目旨在阐明性伴侣，药物使用和性创伤对风险行为的影响，利用演员伴侣相互依存模型框架（APIM）中纵向二元分析的风险行为。 具体来说，我将以下教育和研究目标提出：1。学习如何应用APIM（理论模型）来解释夫妻的行为及其对干预措施的反应，并使用相关的纵向二元统计技术（分析组件）分析现有数据集。 此外，我建议对研究项目进行分析，以使用现有的R01：2。解决创伤，毒品使用，性伴侣和HIV对个人，夫妇和人口水平的健康行为和健康成果的互动效应，利用纵向多个小组使用纵向多个小组，参与者伴侣互动模型（APIM）对于不体定式的策略和分析型号和分析技能。该APIM将纵向结构方程模型建模的复杂技术应用于分析群体格式的分析，解决了伴侣的相对影响和对风险行为的中介因素的相对影响，这将使我能够获得关键技能来解释二元数据，并为我提供桥梁的桥梁，以开发二聚体转化的研究模型和方法，以供夫妻进行材料的干预。通过K18的支持将提供受保护的时间，以获得二元和公共卫生统计方法和模型的能力，而我的研究合作在奖励期间提供了剩余的50％时间。 PUBLIC HEALTH RELEVANCE: As a mid-career investigator in applied behavioral and social sciences related to HIV/AIDS, my goal in applying for a Short-term Mentored Career Development Award (K-18) is to learn to employ hierarchical linear modeling/structural equation modeling analytic strategies to more adequately address the complexity of the dyadic data sets generated by my research on HIV prevention with couples.这些数据集解决了创伤，药物使用，性伴侣以及HIV对个人，夫妇和人口水平的健康行为和健康成果的互动效果。