2/2 Howard-Georgetown Collaborative Partnership in Cancer Research

2/2 霍华德-乔治敦癌症研究合作伙伴关系

• 批准号: 10004016
• 负责人: Lucile Lauren Adams-Campbell
• 金额: $ 21.81万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004016
• 关键词: Address; Advanced Malignant Neoplasm; Advisory Committees; Affect; African American; Applications Grants; Award; Biological; Biological Markers; Biomedical Research; Breast Cancer survivor; Candidate Disease Gene; Categories; Chronic stress; Collaborations; Communities; Comprehensive Cancer Center; Data; Discipline; District of Columbia; Elements; Environment; Faculty; Foundations; Funding; Genetic; Goals; Historically Black Colleges and Universities; Individual; Infrastructure; Institution; Knowledge; Lead; Malignant Neoplasms; Mentors; Metabolic; Minority; Mission; Molecular Profiling; Office of Administrative Management; Outcome; Pathway interactions; Patients; Physical activity; Pilot Projects; Policies; Population; Postdoctoral Fellow; Process; Program Evaluation; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Sharing; Resources; Scientist; Social Justice; Structure; Students; Training; Training Programs; Training and Education; Underrepresented Students; Universities; Vision; allostatic load; anticancer research; base; cancer education; cancer health disparity; career development; clinical care; cohort; curriculum development; education research; experience; falls; follow-up; genetic signature; health disparity; innovation; insight; interest; member; non-alcoholic fatty liver disease; programs; recruit; research study; summer research; university student

Overall Abstract The overarching goal of the NCI Collaborative P20 Partnership in Cancer Research is to enhance cancer research capacity at Howard University and increase participation in cancer health disparities research at Georgetown Lombardi Comprehensive Cancer Center (GU). The Partnership goals will be achieved through two primary mechanisms: pilot research projects and cancer research education. The P20 will benefit from the guidance of an Internal Advisory Committee (IAC) made up of highly qualified and experienced scientists. The Research Pilot Projects will fund four 2-year collaborative research pilot projects. Each project will include at least one investigator from Howard and one from Georgetown. The investigators will benefit from the HU/GU CTSA and the Shared Resources available at GU. Pilot project 1 will identify candidate genes and genetic pathways associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The research will inform possible biological mechanisms underlying the molecular and genetic signatures of perturbed metabolic and mechanistic pathways in NAFLD patients in an African–American population. Results may lead to innovative non-invasive biomarkers. Research Project 2 will investigate disparities in chronic stress, quality of life, and physical activity among Black and White breast cancer survivors. This study will provide insight into whether an association exists between physical activity and allostatic load in breast cancer survivors. During the course of the award, the P20 Partnership will elicit two additional pilot studies through a competitive process which will be driven by a merit review by the IAC. The expected outcome of the pilot projects is the submission of successful collaborative grant applications supported by the preliminary data obtained via the pilot research. The C-REP will contribute to the goals of the Partnership by engaging a diverse group students and faculty who are under-represented as investigators in biomedical research. A cohort consisting of a mix of college students in their junior or senior year, graduate and professional students will be recruited annually for an intensive 8-week mentored summer research experience. Follow-up mentoring will be provided to promote entry into a graduate or professional program or postdoctoral research training. Postdoctoral fellows and faculty will receive training and mentoring to support attaining a robust, high quality publication record and submission of highly competitive independent research proposals. Mentoring within the C-REP will occur via teams of at least one faculty member from both institutions. The Howard-Georgetown P20 Partnership brings many strengths including a large pool of under- represented students and faculty at Howard University, extensive research resources through GU, and a foundation of longstanding, productive partnerships between the two institutions.

总体抽象 NCI合作P20癌症研究合作伙伴关系的总体目标是增强癌症 霍华德大学的研究能力，增加参与癌症健康分布研究 乔治敦伦巴第综合癌症中心（GU）。合伙目标将通过 两种主要机制：试点研究项目和癌症研究教育。 P20将从 内部咨询委员会（IAC）的指导由高素质和经验丰富的科学家组成。这 研究试点项目将资助四个为期两年的合作研究试点项目。每个项目都将包括 至少有一位来自霍华德的调查员和乔治敦的一名调查员。调查人员将从HU/GU中受益 CTSA和GU的共享资源。试点项目1将识别候选基因和通用 与非酒精性脂肪肝病（NAFLD）相关的途径。该研究将告知可能 扰动代谢和机械的分子和遗传特征的生物学机制 非裔美国人人口中NAFLD患者的途径。结果可能导致创新的非侵入性 生物标志物。研究项目2将调查慢性压力，生活质量和体育锻炼的分布 在黑人和白色乳腺癌中存活。这项研究将提供有关是否存在关联的见解 在乳腺癌存活中的体育活动和同层负荷之间。在奖励期间，P20 合作伙伴关系将通过竞争过程进行另外两项试点研究，这将由优点驱动 IAC审查。试点项目的预期结果是提交成功的合作赠款 通过试点研究获得的初步数据支持的应用程序。 C-REP将有助于 通过与人数不足的潜水员团体学生和教职员工交往，伙伴关系的目标 生物医学研究的研究者。由大三或高中的大学生组成的队列 一年，研究生和专业学生将每年招募为期8周的夏季指导 研究经验。将提供后续的心理，以促进进入研究生或专业人士 计划或博士后研究培训。博士后研究员和教师将接受培训和心理 支持获得强大的高质量出版记录和提交高度竞争的独立 研究建议。 C-REP内的指导将通过至少一名教职员工的团队进行 机构。霍华德·乔治镇P20合作伙伴关系带来了许多优势 代表霍华德大学的学生和教职员工，通过GU的广泛研究资源， 两个机构之间的长期，生产伙伴关系的基础。