I-REACH: Infrastructure for Research in Equity, Aging, Cancer and Health

I-REACH：公平、老龄化、癌症和健康研究基础设施

• 批准号: 10527202
• 负责人: Lucile Lauren Adams-Campbell
• 金额: $ 25.84万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527202
• 关键词: Address; Affect; Age; Aging; Area; Award; Behavioral; Cancer Center; Cancer Survivor; Cancer Survivorship; Caring; Cause of Death; Chronic Disease; Clinical; Clinical Research; Collaborations; Communities; Data; Databases; Discipline; Disease; Distance Learning; Educational Curriculum; Elderly; Enrollment; Ethnic Origin; Exposure to; Foundations; Funding; Future; Geriatrics; Gerontology; Geroscience; Goals; Grant; Health; Health Care Costs; Infrastructure; Intervention; Investments; Knowledge; Laboratories; Malignant Neoplasms; Maryland; Mentors; Methodology; Minority; Minority Groups; NCI Scholars Program; Older Population; Oncology; Phase; Population; Quality of life; Reduce health disparities; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Self Efficacy; Senior Scientist; Site; Socioeconomic Status; Source; Survivors; Training; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; Variant; Woman; Work; cancer care; care systems; career; career development; clinical care; cohort; data resource; demographics; disparity reduction; ethnic minority population; health disparity; health equity promotion; human old age (65+); improved; innovation; meetings; minority communities; minority engagement; minority scientist; mortality; pre-doctoral; programs; racial and ethnic; racial and ethnic disparities; recruit; secondary analysis; social; stakeholder perspectives; success; trend

Cancer is the second most common chronic disease and cause of death in older adults. By 2030, three- quarters of the 22 million cancer survivors will be 65 and older and the number of survivors from racial/ethnic minority groups will increase by 99% vs. 31% for Whites. These trends are creating an ethnogeriatric and fiscal imperative, with healthcare costs of disparities doubling to $50 billion by 2050 due to aging of minority groups and persistently low quality of life and survival. We are ill-prepared to address these crises because there is limited evidence to guide clinical care or efforts to reduce disparities among older cancer survivors. This paucity of data is exacerbated by the low numbers of underrepresented minority (URM) scientists leading studies and limited engagement of minority stakeholders to enhance trust in research, resulting in an under- representation of older minority survivors in studies. Progress has been further hampered by the fact that while researchers from aging and oncology each study disparities, there is no infrastructure integrating these disciplines. To fill this urgent gap, the “Infrastructure for Research in Equity, Aging, Cancer and Health” (I- REACH) will use a multi-level disparities framework to integrate geroscience and stakeholder perspectives into transdisciplinary research bridging the fields of aging, disparities and cancer. I-REACH brings together under one umbrella the accumulated expertise of four cancer center hubs (Georgetown, University of Maryland, Karmanos/Wayne State, UCLA), stakeholders, all the major NIA Center programs and national geriatrics, gerontology and cancer organizations. The goals of I-REACH are to: 1) expand the scientific workforce and increase the proportion of URM scientists committed to, and supported in careers at the intersection of aging, disparities and cancer, and 2) deploy this workforce to accelerate discovery and provide evidence for interventions to improve the health of all older cancer survivors. These goals will be accomplished with three Cores and two Programs in overlapping phases using a distributed resource, distance-learning approach. In the two-year R21 phase, we develop, implement and begin to evaluate Cores (Aim 1) and prepare for R33 transition: a Career Development Core providing a mentoring program and a foundational curriculum; a Data Resources Core enabling use of secondary data to fill knowledge gaps in our disparities framework; and a Stakeholder Core to integrate stakeholder perspectives and support recruitment of older minorities. In the three-year R33 phase, the Cores will be deployed to provide a two-year mentored Scholars program for pre- doctoral, doctoral and early stage to senior scientists (Aim 2) and a Pilot program (Aim 3) funding small grants to address evidence gaps in our multi-level framework and build sustainability and disseminate results (Aim 4). Eighty-six scientists (65% women and 36% URM) have already agreed to participate. I-REACH will provide value-added to the NIH by bridging NIA and NCI priorities and addressing areas not covered in other programs. I-REACH is ideally timed to address needs of a rapidly growing diverse, older population.

癌症是老年人第二大慢性病和死亡原因。到2030年，三 2200万个癌症存活中的四分之一及以上年龄在65岁及以上，种族/族裔的生存数量 白人的少数群体将增加99％，而31％的人将增加。这些趋势正在创造一个民族脑病和财政 当务之急，由于少数群体的老龄化，到2050年的医疗保健费用将差异成本翻了一番，到500亿美元 并持续低廉的生活质量和生存。我们为解决这些犯罪做准备不足，因为有 有限的证据指导临床护理或努力减少旧癌症生存的分布。这 由于代表性不足的少数民族（URM）科学家的领导者数量少，数据的稀少会加剧 研究和少数利益相关者的参与有限，以增强对研究的信任，从而导致不足 在研究中代表老年少数族裔冲浪者。在 衰老和肿瘤学的研究人员每个研究差异都没有基础设施来整合这些 学科。为了填补这一紧急差距，“公平，衰老，癌症和健康研究基础设施”（I- 触及）将使用多层次分布框架将Geroscience和利益相关者的观点整合到 跨学科研究桥接了衰老，差异和癌症领域。我的触角融合在一起 一个雨伞是四个癌症中心枢纽的积累专业知识（马里兰大学乔治敦， Karmanos/Wayne State，加州大学洛杉矶分校），利益相关者，所有主要NIA中心计划和国家老年医学家， 老年医学和癌症组织。 I-reach的目标是：1）扩大科学劳动力和 增加致力于职业的URM科学家的比例 差异和癌症，以及2）部署此劳动力以加速发现并提供证据 改善所有老年癌症幸存者健康的干预措施。这些目标将通过三个 使用分布式资源，远程学习方法，核心和两个程序中的两个程序。在 我们开发，实施并开始评估核心（AIM 1）并为R33做准备的两年年R21阶段 过渡：提供心理计划和基础课程的职业发展核心；数据 资源核心促进使用辅助数据来填补我们的分布框架中的知识空白；和 利益相关者的核心融合利益相关者的观点并支持少数民族的招募。在 三年R33阶段，将部署核心，以提供为期两年的学者计划 高级科学家（AIM 2）和试点计划（AIM 3）资助小型赠款的博士学位，博士和早期阶段 解决我们多层次框架中的证据差距，建立可持续性并传播结果（AIM 4）。 86名科学家（65％的女性和36％的URM）已经同意参加。我将提供 通过桥接NIA和NCI的优先级，并解决其他未涵盖的区域，从而增值了NIH 程序。理想情况下，I-reach是满足迅速发展的潜水员，老年人群的需求的时间。