Molecular Biology and Genotyping Core

分子生物学和基因分型核心

• 批准号: 10001529
• 负责人: Akiko Maeda
• 金额: $ 8.28万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001529
• 关键词: Biological; Core Grant; Equipment; Genotype; Housing; Human Resources; Individual; Laboratories; Location; Methods; Molecular Biology; Mus; Mutation; Research; Research Personnel; Resources; Running; Savings; Science; Services; Time; Training; Vision; Vision research; cost; cost efficient; experience; mouse model; ranpirnase; vision science

The objective of the Molecular Biology and Genotyping Module is to enhance the capabilities of individual laboratories in conducting vision science research that requires genotyping of mouse models and use of other molecular biology methods. Accordingly, the Specific Aims of this Module are as follows: 1) to provide a centralized location and support for mouse genotyping; 2) to train researchers and provide individual laboratories with assistance in their molecular biology projects; and 3) to provide training and access to shared molecular biology equipment. The availability of this Module, run by highly experienced personnel, helps VSRC investigators to efficiently manage their mouse colonies, reduce the cost of mouse housing, detect and eliminate undesired mutations, increase the utility of mouse models in their research, and ultimately make their science more cost-efficient and biologically relevant. Time- and resource-saving services of the Molecular Biology and Genotyping Module are of great value to vision researchers at Case.

分子生物学和基因分型模块的目的是增强个体的能力 进行视觉科学研究的实验室，需要小鼠模型的基因分型并使用其他 分子生物学方法。因此，该模块的具体目的如下：1）提供一个 集中位置和对小鼠基因分型的支持； 2）培训研究人员并提供个人 在其分子生物学项目中协助的实验室； 3）提供培训并获得共享 分子生物学设备。由经验丰富的人员运行的该模块的可用性帮助VSRC 调查人员有效地管理其小鼠菌落，降低小鼠外壳的成本，检测和 消除不希望的突变，增加小鼠模型在研究中的效用，并最终使他们 科学更具成本效益和生物学上的相关性。分子的时间和资源服务 生物学和基因分型模块对案例的视力研究人员具有很大的价值。