Biorepository and Animal Core
生物样本库和动物核心
基本信息
- 批准号:10026254
- 负责人:
- 金额:$ 17.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-10 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAlcoholic Liver DiseasesAnimal ExperimentationAnimal ModelAnimalsAutopsyBiologicalBiologyCenters of Research ExcellenceCharacteristicsDataDevelopmentEnsureEquipment and supply inventoriesEvaluationExperimental Animal ModelExperimental ModelsFeesFosteringFutureGerm-FreeGnotobioticGoalsHepatocyteHistologyHumanHuman ResourcesIACUCIn VitroIndividualInfrastructureInstitutionInstitutional Review BoardsLiverLiver diseasesMaintenanceMalignant neoplasm of liverMeasuresMissionModelingMusOccupationalOperative Surgical ProceduresPhenotypeProceduresProtocols documentationResearchResearch PersonnelResourcesSamplingService delivery modelServicesSpecimenStandardizationStructureSystemTechniquesTissue BanksToxicologyTrainingTraining and EducationTranslational Researchbiobankbiological specimen archivescareer developmentdesignexperimental studyflexibilitygut microbiomehuman subjectinterestinvestigator trainingmeetingsmembermetabolic phenotypesample collectionsuccess
项目摘要
Project Summary Abstract – Animal Model and Biorepository Core (Core D)
The Animal Model and Biorepository Core (Core D) of the Hepatobiology and Toxicology Center provides the
essential expertise, facilities, resources, and standardized services required for impactful liver research. The
Core focuses on the needs of the COBRE’s junior investigators, but it also serves other Center members and
liver investigators. The Core enhances infrastructure as well as the technical and academic capabilities of the
Center and the Institution as a whole. Core D’s primary functions are to provide COBRE members with access
to: (i) animal models of liver disease (including the characterization of these models); (ii) primary liver cells; and
(iii) previously collected, de-identified biological specimens from human subjects with liver disease.
The Core’s experimental model services include: animal exposure; husbandry; necropsy with tissue collection,
processing and biorepository storage; phenotyping and liver histology; as well as the isolation of primary hepatic
cells for ex vivo and in vitro studies. The Core will assist COBRE members in developing new experimental
animal models and in vitro systems to study liver disease. The Core will serve as a liaison to non-duplicative
animal research resources at UofL’s two other COBRE Centers to maximize overall impact. Core personnel will
ensure uniformity of husbandry as well as sample collection, processing and evaluation so that the same set of
characteristics is measured in each model. This uniformity ensures that the data generated within the COBRE
are consistent and that results of one experiment will be directly comparable with the results of another. The
Core’s human biorepository enables access to a unique inventory of previously collected de-identified biological
samples from subjects with liver diseases (e.g., alcoholic liver disease, occupational/environmental liver
diseases, liver cancer, etc.) in order to promote translational research. Core D will assist COBRE members with
the necessary regulatory approvals for their research. In addition to its function as a service core, Core D will
promote the education and training of the COBRE junior investigators and members.
To function as a vital integrative component of the COBRE providing services not only for its members but also
for the Institution as a whole, Core D has the following Specific Aims: 1) To foster the development and success
of current and future COBRE projects. 2) To educate and train investigators. 3) To develop new protocols and
techniques. 4) To become an integral and self-sustaining component of the COBRE.
项目摘要摘要 – 动物模型和生物样本库核心(核心 D)
肝生物学和毒理学中心的动物模型和生物样本库核心(Core D)提供了
有影响力的肝脏研究所需的基本专业知识、设施、资源和标准化服务。
Core 专注于 COBRE 初级研究人员的需求,但它也为其他中心成员和
该核心增强了肝脏研究人员的基础设施以及技术和学术能力。
中心和整个机构的主要职能是为 COBRE 成员提供访问权限。
(i) 肝病动物模型(包括这些模型的特征);和 (ii) 原代肝细胞;
(iii) 先前从患有肝病的人类受试者中收集的、去识别化的生物样本。
核心的实验模型服务包括:动物暴露;尸检和组织收集;
加工和生物样本库储存;表型分析和肝脏组织学以及原代肝脏的分离;
用于离体和体外研究的细胞 The Core 将协助 COBRE 成员开发新的实验。
研究肝病的动物模型和体外系统将充当非重复的联络人。
伦敦大学另外两个 COBRE 中心的动物研究资源将最大限度地发挥核心人员的整体影响。
确保饲养以及样品采集、处理和评估的一致性,以便同一套
在每个模型中测量特征,这种一致性确保了 COBRE 内生成的数据。
一致,并且一个实验的结果可以直接与另一实验的结果进行比较。
Core 的人类生物存储库能够访问之前收集的、未识别的生物的独特库存
来自患有肝病(例如酒精性肝病、职业性/环境性肝病)受试者的样本
疾病、肝癌等)以促进转化研究,Core D 将协助 COBRE 成员。
除了作为服务核心的功能外,Core D 还将获得其研究所需的监管批准。
促进 COBRE 初级研究者和成员的教育和培训。
作为 COBRE 的重要综合组成部分,不仅为其成员提供服务,而且还为其成员提供服务
对于整个机构而言,核心 D 有以下具体目标: 1) 促进发展和成功
当前和未来的 COBRE 项目 2) 教育和培训研究人员 3) 制定新的协议和
4) 成为 COBRE 不可或缺的、自我维持的组成部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Matthew C Cave', 18)}}的其他基金
Summer Environmental Health Sciences Training Program
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m6A Epitranscriptomics in Toxicant Associated Steatohepatitis
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Summer Environmental Health Sciences Training Program
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10469317 - 财政年份:2021
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m6A Epitranscriptomics in Toxicant Associated Steatohepatitis
m6A 表观转录组学在中毒性相关脂肪性肝炎中的应用
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