Patient Oriented Research in Type 2 Diabetes

2 型糖尿病以患者为导向的研究

基本信息

批准号：
7459811
负责人：
FREDERICK L BRANCATI
金额：
$ 18.89万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-15 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7459811
关键词：
Accounting Achievement Acute Address Admission activity Adopted Adult African American Aging Allergy and Immunology American American Heart Association American Public Health Association Ancillary Study Andrology Animal Experimentation Animals Anthropology Antihypertensive Agents Area Arts Attention Authorship Award Back Baltimore Baptist Church Basic Science Behavior Therapy Behavioral Mechanisms Behavioral Medicine Behavioral Research Berlin Biochemistry Biological Markers Biology Biometry Blood Circulation Blood Vessels Body Weight decreased Boston Budgets Cardiac Cardiology Cardiovascular Diseases Cardiovascular system Caring Case Study Cause of Death Centers for Disease Control and Prevention (U.S.)Chronic Disease Class Clinic Clinical Clinical Research Clinical Trials Clinical and Translational Science Awards Clip Codes of Ethics Coffee Collaborations Color Commit Communities Community based prevention Computer Hardware Computer software Condition Conflict of Interest Consent Consult Country County Critiques Daily Data Data Analyses Data Collection Data Security Databases Decision Making Depth Developed Countries Developing Countries Development Diabetes Mellitus Diabetes prevention Diabetic Nephropathy Direct Costs Discipline of obstetrics Doctor of Philosophy Education Educational Curriculum Educational process of instructing Electronic Mail Elements Employee Employee Strikes Employment End stage renal failure Endocrine Gland Neoplasms Endocrinology Engineering Enrollment Environment Environmental Risk Factor Epidemic Epidemiologic Methods Epidemiology Equilibrium Equipment Ethical Issues Ethical Theory Ethics Evaluation Evidence Based Medicine Exercise Exercise Physiology Exercise stress test Exposure to Faculty Family Practice Feedback Fellowship Fertilization Financial Support Fire - disasters Foundations Functional disorder Funding General Population Genetic Genetic Research Geriatrics Germany Gestational Diabetes Gifts Goals Grant Guidelines Gynecology HIV vaccine HPSE gene Healed Health Health Benefit Health Policy Health Sciences Health Services Health Services Research Heart Heart Diseases Heavy Metals Hepatic Hepatitis Hepatology Hospitals Hour House Staffs Housing Human Human Rights Hyperglycemia Hypertension Illinois Incubated Individual Inflammation Information Technology Informed Consent Inpatients Institution Insulin Insulin Resistance Intelligence Internal Medicine International Internet Internist Interview Joints Journals Justice K-Series Research Career Programs Kidney Diseases Knowledge Laboratories Laboratory Scientists Laws Lead Leadership Left Letters Licensing Life Light Link Literature Liver diseases Louisiana Magnetic Resonance Mails Malignant Neoplasms Manuscripts Marshal Maryland Master&apos s Degree Mathematics Measurement Medical Medical Libraries Medical Students Medical center Medicine Mental Depression Mentors Mentorship Metabolic Bone Diseases Metabolic syndrome Metabolism Metals Methodology Methods Mid-Career Clinical Scientist Award (K24)Minnesota Minority Mission Modeling Molecular Epidemiology Molecular Genetics Morals Myron NCI Scholars Program Nail plate Names National Institute of Diabetes and Digestive and Kidney Diseases Nature Neuroendocrinology Neurology Neutron Activation Analysis New England Non-Insulin-Dependent Diabetes Mellitus Nursing Research Nutritionist Obesity Online Systems Operations Research Ophthalmology Other Minority Pan American Health Organization Paper Participant Pathology Patients Pattern Pediatric Research Peer Review Periodontic specialty Persons Philadelphia Physical Examination Physicians Physiology Placebos Population Positioning Attribute Postdoctoral Fellow Preparation Prevention Prevention Research Preventive Medicine Primary Health Care Principal Investigator Procedures Process Professional Ethics Psychology Public Health Public Health Nurses Public Health Nursing Public Health Schools Publications Published Comment Publishing Purpose Quality of Care Questionnaires Recording of previous events Recruitment Activity Rehabilitation therapy Research Research Design Research Ethics Research Ethics Committees Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Proposals Research Subjects Research Support Research Training Residencies Resources Review Literature Risk Risk Factors Role Running SAS Sample Size Sampling Schedule Schools Science Scientist Score Secondary Prevention Self Care Series Services Site Slide Social Welfare Societies Sociology Solid Source Statistical Methods Steatohepatitis Stream Stress Structure Students Syphilis Taiwan Talents Taxes Techniques Testing Thinking Time Training Training Programs Translational Research Translations Underrepresented Minority United States Agency for Healthcare Research and Quality United States Health Resources and Services Administration United States National Institutes of Health Universities Update Vaccine Research Variant Vascular Diseases Venous blood sampling Visit Wages Week Weight Woman Women&apos s Health Work World Health Organization Writing abstracting base bench to bedside cardiovascular disorder prevention career clinical epidemiology college community intervention computerized cost day design diabetes risk disability epidemiology study essays experience follow-up genetic epidemiology glycemic control healing health economics health literacy human subject hypothalamic-pituitary-adrenal axis improved instructor interest lecturer lectures lifestyle intervention medical schools medical specialties member minority health multidisciplinary next generation non-alcoholic non-alcoholic fatty liver novel novel strategies nutrition obesity treatment patient oriented patient oriented research post-doctoral training pre-doctoral pressure professor programs protocol development research and development skills statistics sugar symposium theories

项目摘要

DESCRIPTION (provided by applicant): Despite major advances in treatment during the past decade, type 2 diabetes remains a leading cause of death and disability. Improved strategies for primary and secondary prevention are urgently required to check the expanding public health burden related to type 2 diabetes. In the US, the need for such advances is especially acute in African Americans and other minority populations, who suffer disproportionately from type 2 diabetes and its complications, yet enjoy less access to high-quality medical care. To make these advances, young patient-oriented researchers will need mentorship in the areas of molecular epidemiology, clinical epidemiology, clinical trials, preventive medicine, and translational research. As an expert in these areas, the candidate proposes to apply K24 funds towards the mentorship of a growing cadre of young, patient-oriented scholars at Johns Hopkins committed to the epidemiology and prevention of type 2 diabetes and its complications, with special emphasis on diabetes in the African American community. Specific aims on the way to this overarching goal are as follows: (1) Recruit a multi-disciplinary team of talented young diabetes scholars; (2) Promote formal training in epidemiology and clinical research methods; (3) Place trainees in a rich, supportive, highly collaborative research environment; (4) Guide trainees towards novel research questions that spark collaborations with laboratory scientists and sub-specialty experts in patient- oriented research; and (5) Provide research mentorship for projects based in Look AHEAD--an on-going multi-center NIH-funded trial designed to be the definitive test of the health benefits of weight loss in 5000 adults with type 2 diabetes). At Hopkins, three NIH-funded Ancillary Studies to Look AHEAD (each lead by a junior faculty who wrote their grant under Dr. Brancati's mentorship) create outstanding opportunities for young diabetes scholars: (1) an magnetic resonance-based study of Non-Alcoholic Fatty Liver Disease and Hepatic Energy Homeostatis (n=244); (2) a study of Heavy Metals, Obesity, and CVD Risk that uses neutron activation analysis to determine metal content of nail clippings (n=3000); and (3) a study of Environmental Influences on Weight, Weight Loss, and Related Factors that uses geocoding to link residential address to publicly available data on the local environment (n=1200). Dr. Brancati has already established a strong track record of mentorship in patient-oriented research in the epidemiology and prevention of type 2 diabetes and its complications. During the initial four years of the K24 Award (2002-2006), he successfully mentored 6 PhD students, 3 post-doctoral fellows, 2 medical residents, and 5 junior faculty members who published 42 first-author manuscripts. With continued K24 support, he can expand the breadth of his mentorship activities, draw even more young scholars into patient-oriented diabetes research at Hopkins and train the next generation of top mentors in patient-oriented diabetes research.

描述（由申请人提供）：尽管过去十年在治疗方面取得了重大进展，2 型糖尿病仍然是死亡和残疾的主要原因。迫切需要改进一级和二级预防策略，以遏制与 2 型糖尿病相关的不断扩大的公共卫生负担。在美国，非裔美国人和其他少数族裔尤其迫切需要此类进步，他们不成比例地患有 2 型糖尿病及其并发症，但获得高质量医疗服务的机会却较少。为了取得这些进展，以患者为中心的年轻研究人员将需要分子流行病学、临床流行病学、临床试验、预防医学和转化研究领域的指导。作为这些领域的专家，候选人提议将 K24 资金用于指导约翰·霍普金斯大学不断壮大的以患者为中心的年轻学者队伍，致力于 2 型糖尿病及其并发症的流行病学和预防，特别是糖尿病在非裔美国人社区。实现这一总体目标的具体目标如下：（1）招募一支多学科、年轻的糖尿病学者团队； (2) 促进流行病学和临床研究方法的正规培训； (3) 将学员置于丰富的、支持性的、高度协作的研究环境中； (4) 引导学员解决新颖的研究问题，激发与实验室科学家和亚专业专家在以患者为导向的研究中的合作； (5) 为 Look AHEAD 项目提供研究指导，Look AHEAD 是一项由 NIH 资助、正在进行的多中心试验，旨在对 5000 名患有 2 型糖尿病的成年人进行减肥对健康的益处进行最终测试。在霍普金斯大学，三项由美国国立卫生研究院 (NIH) 资助的展望未来的辅助研究（每项均由在布兰卡蒂博士的指导下撰写资助的初级教师领导）为年轻的糖尿病学者创造了绝佳的机会：(1) 一项基于磁共振的非酒精研究脂肪肝疾病和肝能量稳态（n=244）； (2) 一项关于重金属、肥胖和 CVD 风险的研究，利用中子活化分析来确定指甲剪下的金属含量 (n=3000)； (3) 环境对体重、体重减轻和相关因素的影响研究，该研究使用地理编码将居住地址与当地环境的公开数据联系起来 (n=1200)。 Brancati 博士在 2 型糖尿病及其并发症的流行病学和预防领域以患者为导向的研究方面已建立了良好的指导记录。在K24奖的最初四年（2002-2006）期间，他成功指导了6名博士生、3名博士后研究员、2名住院医生和5名初级教师，发表了42篇第一作者手稿。在 K24 的持续支持下，他可以扩大指导活动的广度，吸引更多年轻学者进入霍普金斯大学以患者为导向的糖尿病研究，并培训下一代以患者为导向的糖尿病研究的顶级导师。