CORE B: HEALTH CARE AND POPULATION SCIENCE CORE

核心 B：医疗保健和人口科学核心

基本信息

批准号：
9221321
负责人：
FREDERICK L BRANCATI
金额：
$ 41.91万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9221321
关键词：
Adult Archives Area Attention Behavior Behavior Therapy Behavioral Biometry Body Weight decreased Caring Clinic Clinical Clinical Trials Collaborations Communities Complications of Diabetes Mellitus Creativeness Data Quality Databases Development Diabetes Mellitus Diabetes prevention Discipline of Nursing Disease Management Elderly Epidemic Epidemiology Evidence Based Medicine Fostering Funding Guidelines Health Health Care Research Health Policy Health system Healthcare Heart Diseases Human Intervention Investigation Knowledge Laboratories Laboratory Research Link Malignant Neoplasms Marketing Maryland Meta-Analysis Molecular National Institute of Diabetes and Digestive and Kidney Diseases Non-Insulin-Dependent Diabetes Mellitus Nurses Outcomes Research Paper Patient Care Patients Pharmaceutical Preparations Pharmacotherapy Physiological Population Population Research Population Sciences Psychometrics Public Health Publications Research Research Personnel Research Project Grants Research Support Resources Risk Factors Role Safety Science Scientist Services Talents Training Programs Translational Research Universities bariatric surgery base bench to bedside biomarker discovery cancer risk clinical decision-making clinical practice collaborative environment combat comparative comparative effectiveness design effectiveness research experience health disparity interest medical schools novel nutrition related genetics patient safety personalized medicine population health severe mental illness symposium systematic review treatment strategy trial design web site

项目摘要

The NIDDK framework for translational research is expansive, ranging from bench to bedside all the way up to community-based interventions. But this extensive framework leaves some important gaps: (1) It sometimes disconnects laboratory from population research, impeding discovery of novel risk factors for diabetes and novel complications of diabetes or diabetes treatment; (2) It sometimes assumes that large trials have made treatment and prevention of diabetes matters of 'settled science', when in fact there are lingering controversies; (3) It generally ignores patient safety as a subject of investigation, despite persistent concerns about safety across a wide range of diabetes drugs and diabetes treatment strategies. (4) It sometimes ignores the underiying clinical complexity of patients with diabetes, especially those who are older or who have coexisting heart disease or cancer. At the Hopkins-UMD DRC, we have a track record of supporting research that fills these gaps, often with high-impact publications. We propose to construct a Healthcare & Population Science (HPS) Core that support research to fill these gaps and thereby serve a unique role nationally among the DRCs and CDTRs: The HPS Core will have 4 Sub-Cores: (1) Clinical, Molecular, and Pharmaco Epidemiology (Yeh, Segal) (2) Clinical Trials (Brancati, Davis); 3) Behavior & Psychometrics Sub-Core (Hill-Briggs); (4) Biostatistics Sub-Core (Wang). Themes of special interest will include: Health Disparities; Evidence-Based Medicine (including Systematic reviews and Meta-analysis); Novel Risk Factors and Complications; Healthcare interventions (including Population Health and Disease management; Bariatric Surgery; Personalized Medicine; Tailored behavioral interventions; and Drug Safety.

NIDDK 的转化研究框架范围广泛，从实验室到临床一直到以社区为基础的干预措施。但这个广泛的框架留下了一些重要的空白：(1) 有时会导致实验室与人群研究脱节，从而阻碍发现新的危险因素糖尿病和糖尿病或糖尿病治疗的新并发症； (2) 有时假设大试验已使糖尿病的治疗和预防成为“既定的科学”，而事实上有挥之不去的争议； (3) 尽管持续存在，但它通常忽视患者安全作为调查对象人们对各种糖尿病药物和糖尿病治疗策略的安全性感到担忧。 (4)它有时会忽视糖尿病患者潜在的临床复杂性，尤其是那些患有糖尿病的患者老年人或患有心脏病或癌症的人。在霍普金斯大学-马里兰大学 DRC，我们有支持填补这些空白的研究的记录，通常是高影响力的出版物。我们建议构建一个医疗保健与人口科学 (HPS) 核心，支持研究以填补这些空白，从而在刚果民主共和国和 CDTR 中发挥独特的作用： HPS 核心将有 4 个子核心：(1) 临床、分子和药物流行病学（Yeh、Segal） (2) 临床试验（Brancati、Davis）； 3）行为与心理测量子核心（Hill-Briggs）； (4)生物统计学子核心（王）。特别感兴趣的主题包括：健康差异；循证医学（包括系统评价和荟萃分析）；新的风险因素和并发症；卫生保健干预措施（包括人口健康和疾病管理；减肥手术；个性化药品;量身定制的行为干预措施；和药物安全。